University of California, Irvine

Reproducibility, Replicability, and Research Quality in Homogeneous Catalysis

Abstract Researchers from all sectors of homogeneous catalysis convened in response to concerns regarding reproducibility in science to analyze the issue and provide recommendations. In addition to an in-person workshop, the group engaged the broader homogeneous catalysis communi...

Systematic Underestimation of Nonlinear and Synergistic Soil Moisture‐Precipitation Coupling in Convection‐Permitting Models

Abstract Soil moisture‐precipitation coupling critically shapes Earth's water and energy cycles, yet it remains difficult to quantify because land‐atmosphere interactions are nonlinear, multivariate, and state‐dependent. This study applies the High‐Dimensional Model Representatio...

Optimizing CRISPR/Cas9 mutagenesis in Drosophila dendritic arborization neurons to avoid cytotoxicity

Abstract Genetic perturbations are one of the great strengths of the model organism Drosophila melanogaster, with approaches such as classical mutagenesis and RNA interference enabling a wealth of biological discoveries. A more recent approach for altering gene expression is CRIS...

Complementary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

Monogenic syndromes are associated with neurodevelopmental changes that result in cognitive impairments and neurobehavioral phenotypes, including autism and seizures. Limited studies and resources are available to make meaningful headway into the underlying molecular mechanisms t...

Quantum-well metasurface for free-space-accessible enhanced nonlinear polarization

Abstract Nonlinear frequency conversion underpins important technologies such as telecommunications and quantum computation; however, weak nonlinearities and architectures that resist miniaturization currently limit devices’ efficiency and widespread adoption. Here we combine a b...

Comparative Pharmacovigilance Analysis of Safety Signals Among Advanced Prostate Cancer Therapies Using FAERS (FDA Adverse Event Reporting System)

Therapeutic options for advanced prostate cancer have expanded in recent years, incorporating multiple-system treatment approaches with differing mechanisms of action. However, comparative real-world safety data following drug approval remain limited. As such, the aim of this stu...

A Randomized Controlled Trial Evaluating Negative Pressure Therapy (NPT) to Reduce Wound Complications Following Major Lower Extremity Amputation

Objective: This study hypothesizes that negative pressure therapy (NPT) reduces wound-healing complications following major amputation. Background: Major lower extremity amputation carries a high incidence of incisional complications. NPT reduces these complications in other area...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

Endogenously (Non-)Ricardian Beliefs

Replication files for "Endogenously (Non-)Ricardian Beliefs", forthcoming in the International Economic Review

Subanesthetic nitrous oxide alters large-scale network organization and insula connectivity during visual stimulation

Pharmacological agents that alter consciousness, including classic psychedelics and non-classic agents such as nitrous oxide, are known to affect multiple domains of conscious experience, including visual perception. While most neuroimaging studies rely on resting-state data to c...

Observations of Atmospheric Helium and Oxygen With SPHEREx

Abstract We present measurements of near‐infrared (NIR) terrestrial airglow produced by helium and oxygen in the exosphere as observed by the Spectro‐Photometer for the History of the Universe, Epoch of Reionization, and ices Explorer (SPHEREx). Using 8 months of survey data obta...

Stress‐induced trained immunity—A key mechanism linking psychosocial stress, atherosclerosis, and cardiovascular disease

Although chronic psychosocial stress is a well-established independent risk factor for cardiovascular disease (CVD), the underlying mechanisms linking stress to CVD remain incompletely understood. Here, we review clinical and preclinical research documenting how stress can activa...

Neural tracking of surprisal in Spanish-English bilingual children during naturalistic heritage language listening

Our understanding of the neurobiology of language development is imprecise, particularly for bilingual children in their heritage language, since much research focuses on monolingual children or societal majority languages. In this study, we use a novel computational approach wit...

Lipid-driven membrane remodeling engages a lysosome-dependent adaptive repair program during retinal aging

Abstract Age-associated remodeling of membrane lipid composition has been implicated in cellular dysfunction, yet the mechanisms linking lipid changes to membrane integrity and disease remain poorly defined. In the retinal pigment epithelium (RPE), lipid dysregulation is strongly...

Intestinal fructose catabolism promotes obesity and insulin resistance via ileal lacteal remodeling

High-fructose corn syrup (HFCS) consumption is a risk factor for obesity and diabetes, yet the underlying mechanisms, especially at the specific organ level, are incompletely understood. Catabolism of dietary fructose primarily occurs in the small intestine and liver, with fructo...

Causal mediation pathways in continuous postprandial glucose monitoring for type 1 diabetes patients

Abstract Managing postprandial glucose in Type 1 Diabetes Mellitus (T1DM) requires understanding how carbohydrate intake affects glucose through both direct pathways and insulin-mediated compensation. Standard analyses treat insulin as a confounder rather than a mediator, obscuri...

Metabolic control of smooth muscle cell phenotype switching in atherosclerosis

Abstract The loss of smooth muscle cell (SMC) contractile phenotype contributes to various diseases including atherosclerosis. However, its metabolic basis is not entirely elucidated. Since the transforming growth factor beta (TGFβ) signaling is among principal regulators of SMC...

A bundled anti-parallel cytochrome nanowire structure suggests roles in cell-cell electron transfer and biofilm formation

ABSTRACT Long-range extracellular electron transfer enables respiring microbes to use minerals, organisms, or electrodes as electron acceptors by transporting electrons microns away from the cell surface. This process is primarily studied in Geobacter sulfurreducens , which produ...

Machine Learning-Based Classification of Lower Urinary Tract Symptoms from Uroflowmetry: Evaluation Against Physician Decisions and Clinical Nomograms

Lower Urinary Tract Symptoms (LUTS) are commonly evaluated using clinician judgment and nomogram-based methods derived from limited physiological parameters. However, these approaches may not generalize across patient subgroups and may not fully capture patient-specific variabili...

Local Pharmacokinetics and Tolerability of Topically‐Applied Bimatoprost to the Scalp of Male Patients With Androgenetic Alopecia

ABSTRACT Androgenetic alopecia (AGA) is one of the most common causes of hair loss in the male population, characterized by progressive baldness. This study was designed to evaluate the tolerability and local skin pharmacokinetics of bimatoprost in two different formulations in m...