University of California, Irvine

Simulated reductions in heterogeneous isoprene epoxydiol reactive uptake from aerosol morphology in the contiguous United States using the Community Multiscale Air Quality Model (CMAQv5.3.2)

Aerosol particles contain complex mixtures of polar and non-polar species that can undergo organic-inorganic phase separation. In phase-separated aerosol particles, the phase state of the outer organic coating can modulate heterogeneous chemistry. Heterogeneous chemistry leading...

Political Connections, Financial Constraints, and Corporate Taxation

Abstract We find that the effect of political connections on tax planning depends on firms’ financial conditions. After increased political connections, financially unconstrained firms increase tax planning and spending on tax services, as documented in prior studies, whereas con...

Evolving Surgical Paradigms in Early-Stage Cervical Cancer: De-escalation, Minimally Invasive Approaches, and Lymph Node Assessment

Abstract Purpose of Review This review examines the evolving surgical paradigms in early-stage cervical cancer, with an emphasis on the deescalation of radical surgery, the ongoing debate surrounding minimally invasive approaches, and the advancements in lymph node assessment. Re...

Angular gausslets

Gausslets are one of the few basis constructions for electronic structure that combine locality, orthonormality, variable resolution, and an accurate diagonal approximation for the electron-electron interaction, but the original construction is tied to one dimension. Radial gauss...

Situated Practice Systems: A Computational System for Supporting the Coaching and Practice of Regulation Skills for Innovation Work

Students are increasingly expected to prepare for open-ended innovation work, which requires well-developed cognitive, metacognitive, and emotional regulation skills. College learning environments offer opportunities to work on real-world problems—such as in design and engineerin...

From Ionic Agitation to Precision Neuroablation: A Bioengineering Perspective on the Mechanisms, Modalities, and Clinical Applications of Radiofrequency Technology in Pain Management

Radiofrequency ablation (RFA) is a foundational interventional technology in pain management. Despite the diversity of available systems, conventional thermal, internally cooled, bipolar, and pulsed radiofrequency (PRF) all share one biophysical mechanism: high-frequency alternat...

Safety and financial analysis of outpatient HyperCVAD arm A administration for acute lymphoblastic leukemia

IntroductionOur institution transitioned the administration of hyperCVAD arm A to the outpatient setting via an Inpatient/Outpatient (IPOP) program. This study aims to evaluate the safety and financial impact of administering hyperCVAD arm A in the outpatient setting.DesignRetros...

Kant’s Argument that Mathematics is the Science of Magnitude: Comments on Daniel Sutherland’s Kant’s Mathematical World

Abstract The main claims of Kant’s Mathematical World are that for Kant mathematics is a science of magnitudes, the world of experience is a world of magnitudes, and there is an essential role for intuition in representing magnitudes. This paper critically examines the argument f...

Reliability of computational versus noncomputational metrics of working memory and episodic memory in serious mental illness.

= 76). These participants were tested in working memory and episodic memory paradigms. We applied a computational model that yielded parameters corresponding to memory storage capacity, memory precision, and the rate of attention lapses. We also examined a noncomputational metric...

Longitudinal electric vehicle adoption patterns and neighborhood predictors in California

Objective Prior studies of determinants of Zero-Emission Vehicle (ZEV) adoption have relied largely on cross-sectional data, obscuring temporal variation. We identified ZEV adoption trajectories in California ZIP Code Tabulation Areas (ZCTAs) and related them to neighborhood dete...

Integrating HiTOP and clinical staging: A developmental framework for multidimensional psychiatric assessment

Abstract Precise assessment and classification of psychopathology are essential components of precision psychiatry. The transdiagnostic clinical staging model holds tremendous promise to advance classification of psychopathology across the lifespan, but it is currently limited in...

Rethinking Restrictive Diets in IBD: Toward an Inclusion-Focused Nutritional Paradigm

Abstract Purpose of Review Patient-initiated elimination diets are widely adopted by those with inflammatory bowel disease (IBD), yet the evidence supporting their long-term use remains limited and their risks are increasingly recognized. Some common elimination diets utilized by...

Bayesian bilevel operator learning with low-rank adaptation for efficient uncertainty quantification of PDE inverse problems

Abstract Uncertainty quantification in PDE inverse problems is essential in many applications. Scientific machine learning and AI enable data-driven learning of model components while preserving physical structure, and provide the scalability and adaptability needed for emerging...

Optimized Brain Functional MRI for Patients With Deep Brain Stimulation Systems

BACKGROUND AND OBJECTIVES: Deep brain stimulation (DBS) is an established neuromodulation therapy for Parkinson disease and other neurological disorders. Active DBS–functional MRI (fMRI) enables visualization of circuit engagement and may provide objective biomarkers of therapeut...

Intramedullary Bone Transport Nail for the Treatment of Segmental Tibial Bone Defect After Acute Traumatic Bone Loss

SUMMARY: Medullary bone transport is a valuable technique to perform distraction osteogenesis with all-internal components. This technique has notable advantages over other techniques which rely on external pins, wires, and frames. Preoperative templating and surgical planning ar...

Micro-randomized Trials with Categorical Treatments and Binary Proximal Outcome: Causal Effect Estimation and Sample Size Calculation

Abstract Micro-randomized trials (MRTs) provide a framework for evaluating the marginal and moderated effects of mobile health (mHealth) interventions. In many applications, treatments take the form of categorical variables with multiple levels, such as different message contents...

Exposure to airborne fine particulate matter disrupts human embryonic stem cell osteogenic differentiation

Developmental bone toxicity encompasses impairments in skeletal growth and remodeling during embryonic and fetal development that can result in long-term skeletal abnormalities. Airborne fine particulate matter (FPM; ≤ 2.5 μm) is a size-defined fraction of particulate air polluti...

Native Wolbachia infection dynamics across Aedes albopictus (Diptera: Culicidae) populations in Hawaiʻi

Aedes albopictus , an important vector of arboviruses, such as dengue, chikungunya, and Zika, is a widespread invasive mosquito species in the Pacific Islands Countries and Territories, including Hawaiʻi. Wolbachia , an endosymbiotic bacterium, widely used for mosquito control th...

Population-Associated Molecular Variation in Histologically Normal Breast Tissue Is Associated with Distinct Baseline Transcriptional States

Population-associated molecular variation in breast tissue may contribute to differences in tissue biology and disease susceptibility. Still, the extent to which such variation is shaped by underlying tissue state remains unclear. We performed a pilot RNA-seq and lipidomic analys...

Developers’ Experience with Generative AI Beyond Productivity Assessment – Insights from an Empirical Mixed-Methods Field Study

With the growing adoption of AI-powered coding assistants, organizations and developers are increasingly seeking to optimize their interaction with these tools. Prior research has largely focused on output quality and productivity gains, with limited attention paid to developers’...