University of California, Irvine

Landscape of approaches for streamlining pre-analytical and early analytical variables for solid tumor next-generation sequencing: A Genomics Organization for Academic Laboratories consortium report

The scope of pre-analytical and early analytical methods used in clinical molecular laboratories can have vast effects on the quality and turnaround time for solid tumor next-generation sequencing assays. To learn more about various approaches, a survey of 24 academic laboratorie...

Hyperspectral dual-comb compressive ghost imaging with deep learning reconstruction

Ghost imaging reframes image formation by replacing pixelated sensors with correlation measurements between structured illumination and a single-pixel detector, enabling capabilities that are difficult or impossible for conventional cameras. This powerful technique is inherently...

Mixed-Precision Quantization for Language Models: Techniques and Prospects

The rapid scaling of Language Models (LMs) has resulted in unprecedented computational, memory, and energy requirements, making their training and deployment increasingly unsustainable. Quantization has emerged as a crucial compression technique for reducing model size, alleviati...

Developers’ Experience with Generative AI Beyond Productivity Assessment – Insights from an Empirical Mixed-Methods Field Study

With the growing adoption of AI-powered coding assistants, organizations and developers are increasingly seeking to optimize their interaction with these tools. Prior research has largely focused on output quality and productivity gains, with limited attention paid to developers’...

Long-Term Radiographic Changes of Vascularized Pedicled Nasoseptal Flaps After Endoscopic Endonasal Skull Base Surgery

Background: Endoscopic endonasal approaches (EEA) are widely used for a myriad of skull base pathologies. Although historically associated with high cerebrospinal fluid leak (CSF) rates, this risk has been largely mitigated with vascularized nasoseptal flaps (NSF). However, posto...

What is this sophistication thing anyway?

Abstract Following Dewar (2019), ‘reduction’ and ‘sophistication’ are supposed to be two different ways of articulating the shared content of symmetry-related models of physical theories. And yet: there does not exist in the literature a maximally clear, maximally general stateme...

Association of Community Factors, Firearm Laws, and Pediatric Firearm Injuries

OBJECTIVE: To conduct a zip code-level analysis of community measures and firearm legislation associated with pediatric fatal and nonfatal firearm injuries, ordered by strength of association. METHODS: This was an ecological study of 46 states and the District of Columbia from Ja...

The Effects of Homicides on Childcare Classroom Quality and Child Development

Community violence exposure (CVE) can disrupt children’s learning. This study examines how recent homicides near early childhood education providers (ECEPs) affect classroom quality and child outcomes in Colombia. We use data collected from low-income children (age: M = 45.35 mon...

Integrative molecular identification and mitochondrial genetic diversity of cryptic Anopheles vectors in malaria hotspots of northwestern Thailand

The Anopheles barbirostris complex comprises several sibling species capable of transmitting malaria and lymphatic filariasis and is increasingly recognised as a potential contributor to residual malaria transmission in the Greater Mekong Subregion (GMS). However, the morphologic...

An Optimized Bioluminescent Lantern for RNA Imaging

Abstract A complete understanding of RNA dynamics requires methods to continuously image transcripts in living systems. We recently developed a panel of bioluminescent tools for multiplexed RNA detection, comprising luciferase fragments fused to RNA-binding proteins (RNA lanterns...

Clinical trial barriers in neurostimulation for pediatric drug‐resistant epilepsy

Abstract Objective The NeuroPace responsive neurostimulation (RNS) System effectively treats focal drug‐resistant epilepsy (DRE) in adults but lacks pediatric regulatory approval. Despite effective off‐label pediatric use, systemic device‐trial challenges have impeded label expan...

CO2 Electrolysis Paired with Glycerol Oxidation on Transition-Metal Single-Atom Catalysts

Abstract Pairing the carbon dioxide reduction process with the electrocatalytic oxidation of glycerol (GOR), instead of the typically applied oxygen evolution reaction, can substantially decrease the cell voltage while forming high-value products at both electrodes. In this contr...

Cleft Summit 2025: How to Ensure Psychosocial Assessments Actually Improve the Lives of Children with Cleft Lip and/or Palate

Objective The 3 rd Cleft Summit examined whether and how cleft teams assess the psychosocial impact of facial differences on children and their families and sought to develop actionable strategies for improving psychosocial outcomes. Design Expert consensus study followed by a de...

Learning stochastic dynamics and cell-fate landscapes from single-cell snapshots via optimal transport

The temporal dynamics and stochasticity of gene expression are critical to cell fate decisions, yet integrating snapshot omics data across multiple time points remains a major challenge. Here, we introduce DiffusionOT, a dynamic machine learning framework that infers cellular tra...

Existing racial and ethnic representation on top management teams predicts subsequent top management team appointments that preserve the demographic status quo

Top management teams (TMTs) are considerably less diverse than employees at other levels and the general population. Using over 48,000 firm–year observations of executives across 3,807 firms from 1992 to 2017, we find robust evidence that the existing racioethnic composition of T...

Cryptographically Secured Machine Learning for Resilient Multi-Tier Supply Chains

As we move further into a more digital supply chain, we have seen tremendous improvements in terms of efficiency, but we have also seen a rise in the risks that data vulnerabilities pose, particularly for intermediary supply chain nodes. As a result, traditional security measures...

Repeatability and behavioral relationships of acuity, contrast sensitivity, form, and motion perception measurements using a novel tablet-based vision test tool

Abstract Visual function tests are essential in basic and clinical vision research but are typically restricted to a limited range of visual functions and provide coarse diagnostic resolution. The response-adaptive Angular Indication Measurement (AIM) and Foraging Interactive D-p...

Myalgic encephalomyelitis/chronic fatigue syndrome and overlapping post-acute infection syndromes: international expert consensus framework for diagnostic standardization

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) lacks validated objective diagnostic criteria, leading to delayed diagnosis and inconsistent management. We aimed to establish an international expert consensus framework integrating measurable, risk-stratified assessmen...

Causal Explanation from a Conceptual Engineering Perspective: Non-Reductionism, Precision, and Pluralism

Abstract While projects in philosophy of science often focus on similar sorts of topics, there are often massive differences in how philosophers approach them. One approach that has enjoyed significant success—and that is modeled in the work of Wimsatt and others—involves taking...

Cigarette Smoke and E-Cigarette Aerosol Extracts Induce Myelopoiesis and Suppress Inflammatory Cytokine Production

Tobacco and nicotine use remain leading preventable drivers of cancer risk, and both combustible cigarettes and electronic nicotine devices perturb immune function and hematopoiesis. However, side-by-side comparisons of their effects across the hematopoietic hierarchy remain limi...