University of California, Berkeley

The evolution of genetic drift over 50,000 generations

Abstract Random variation in reproductive success–genetic drift–profoundly shapes genetic diversity and evolutionary trajectories. The strength of drift depends on the variance in descendant number, σ2d, which governs key evolutionary outcomes: for instance, the establishment pro...

Opioid-induced respiratory depression or oversedation risk assessment in hospitalized patients with cancer receiving palliative care

Purpose The Oversedation Risk Criteria (ORC) is a prediction model that estimates prescription opioid-induced respiratory depression (OIRD) or oversedation risk in hospitalized patients. The study objectives were to estimate OIRD/oversedation risk via the ORC and to determine the...

Scaffold Fiber Architecture and Uniaxial Stretch Differentially Regulate Cell and Nuclear Morphology in Human Dermal Fibroblasts.

Cellular and nuclear morphology, together with directional alignment, are fundamental determinants of cell function and play critical roles in the formation, organization, and maintenance of functional fibrous connective tissues. In tissue-engineered systems, these characteristic...