University of Bern

Association of admission LDL cholesterol with clinical profile and 3-months outcomes after ischaemic stroke

Abstract Background and aim We investigated whether admission LDL-C levels are associated with clinical profile and outcomes after acute ischaemic stroke by comparing patients stratified into five LDL-C groups. Patients and methods We retrospectively analyzed consecutively includ...

Sleep-stage dynamics predict current sleep-disordered breathing and future cardiovascular risk

ABSTRACT Sleep-disordered breathing (SDB) is a major contributor to cardiovascular morbidity and disrupts both the macrostructure and dynamics of sleep stages (W, N1, N2, N3, REM). While specific alterations in sleep macrostructure, such as reduced durations of N3 and REM, have b...

Session-by-session client feeling and clarification processes over the course of emotion-focused therapy

Background: Emotion-Focused Therapy (EFT) is an effective form of psychotherapy for a range of psychological problems.While earlier research demonstrated the effect of in-session processes as being central for explaining the effects of EFT, it is unclear what the role of client's...

Cross-realm biodiversity integration of the EU environmental policy mix

It is widely accepted that a cross-realm approach, encompassing terrestrial, freshwater and marine ecosystems, is critical for effective biodiversity conservation and restoration. This study is the first to investigate the scope of the European Union's environmental policy mix re...

Developing a summative and integrated framework to assess living lab interventions: Insights and reflections from a multi-site case study

The impact assessment of a Living Lab represents a crucial research challenge given the complexity and diversity of stakeholders and characteristics of Living Labs (e.g., context, scales, and goals). While the literature emphasizes formative approaches focused on performance usin...

Oral health and systemic health outcomes: A call for interdisciplinary action

Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European...

Clinical utility of ultrasound by general practitioners: a systematic review

Abstract Background The clinical use of ultrasound by general practitioners has expanded rapidly, but uncertainty persists in clinical practice regarding which indications can improve diagnostic process and which rather represent low-value care. Methods We conducted a systematic...

Pulmonary Vein Isolation Using Pulsed Field Ablation With vs Without Posterior Wall Isolation in Patients With Symptomatic Persistent Atrial Fibrillation

Importance: Pulmonary vein isolation (PVI) is less effective in persistent than in paroxysmal atrial fibrillation (AF). Objective: To determine whether adding posterior left atrial wall isolation (PWI) to pulsed field ablation (PFA)-based PVI reduces atrial tachyarrhythmia in pat...

Prediction of Treatment Benefit With Internet-Based Cognitive Behavioral Therapy for Depression

Importance Treatment benefit prediction models may help identify which patients will benefit most from internet-based cognitive behavioral therapy (iCBT) for depression; it is unclear whether such models can support useful treatment allocation across programs. Objective To develo...

The Costs of Parkinson's Disease in Europe: Results of the Costs of Illness in Neurology Initiative

Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. It imposes substantial and growing burden on patients, families, and caregivers and reduces quality of life. The disability and care needs associated with PD carry economic ramificat...

Lie structures in homotopy and isotopy calculi

Abstract We establish compatibility of Lie structures that appear in homotopy calculus of functors and isotopy calculus of embeddings. On one hand, we give a new proof of the Johnson–Arone–Mahowald result describing the layers of the Goodwillie tower of the identity functor, and...

Cheminformatic identification of small molecules targeting acute myeloid leukemia

Abstract Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor prognosis and high relapse rates when treated with cytotoxic chemotherapeutics. Previously, we identified a family of small molecules that modulate mitochondrial function, referred to as PS1...

Glucose-based fluid creep or maintenance fluids in critically ill adult patients: a scoping review of the available evidence related to blood glucose control

Abstract Background Fluid therapy is a fundamental aspect of intensive care unit treatment, encompassing resuscitation, maintenance, nutrition, and hidden fluid "creep" to keep lines open or dilute drugs. While most research has focused on resuscitation fluids, maintenance and fl...

Deep learning aging marker from retinal images unveils sex-specific clinical and genetic signatures

Abstract Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tune a foundation model (RETFound) to predict chronological age from color fundus images in 71,343 participants from the UK Biobank, achieving a mean absolute error of 2.85 years. The re...

Radiocarbon in atmospheric CH 4 and CO 2 at Jungfraujoch in 2019–2024: influence of regional nuclear emissions and current global atmospheric 14 CH 4 signal

Abstract. Radiocarbon (14C) is a valuable tracer to determine the relative fossil fractions of emitted carbonaceous greenhouse gases, such as CO2 and CH4. While atmospheric ∆14CO2 measurements have been conducted at multiple sites for several decades, ∆14CH4 measurements remain m...

A Surgical Algorithm for Upper Cervical Trauma Based on the AO Spine Upper Cervical Injury Classification System

Study Design. Global cross-sectional survey Objective. To establish a surgical algorithm for upper cervical spine injuries using the AO Spine Upper Cervical Injury Classification (UCIC) system, defining operative thresholds using a novel proposed Upper Cervical AO-Spine Injury Sc...

Clinical and neurobiological correlates of tardive dyskinesia in schizophrenia spectrum disorders and mood disorders

Abstract Tardive dyskinesia (TD) is a persistent sensorimotor syndrome associated with antipsychotic exposure in schizophrenia spectrum disorders (SSD) and mood disorders (MOD), yet its neurobiological basis remains poorly understood. We investigated whether TD represents a disti...

SINE Insertion in LAMA3 in Dogs With Junctional Epidermolysis Bullosa

ABSTRACT Junctional epidermolysis bullosa (JEB) is a hereditary skin disorder caused by defects in proteins responsible for dermal‐epidermal adhesion. We investigated the genetic cause of JEB in three related mixed‐breed puppies presenting with congenital skin blistering and ulce...

Gaussian Process Modeling with Genotype $$\times $$ Environment Kernels for Wheat Performance Prediction

Abstract Optimizing wheat variety selection for high performance in different environmental conditions is critical for reliable food production and stable incomes for growers. We employ a statistical machine learning framework utilizing Gaussian process (GP) models to capture the...

Characterizing tree species richness in Indigenous Peoples’ lands: addressing often-overlooked data limitations and biases

Abstract Several studies have characterized species richness distribution in Indigenous Peoples’ Lands (IPL) using global biodiversity datasets. However, these datasets contain substantial limitations and biases which may compromise the accuracy of spatial biodiversity assessment...