University of Bern

Impact of imidacloprid on honey bee hypopharyngeal glands at two levels: measurement reliability and laboratory versus field conditions

The use of neonicotinoids has undoubtedly behavioral and physiological effects on bees. This work aimed to ring test the digital measurement of honey bees’ hypopharyngeal glands (HPGs), validate the method against the subjectivity of the assessors, and assess differences in the i...

Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs

About 50 years after their development, the benzimidazole anthelmintic drugs still occupy a key role in the treatment of parasitic diseases. Like other anti-infective drugs, their extensive use has led to resistance development and now requires new solutions to treat these diseas...

404: Personal data not found — Anonymous vs. account-based internet self-help for social anxiety in a partially randomized patient preference trial

Background Privacy and data security concerns are frequently cited barriers to the adoption of internet-based interventions. Allowing anonymous use may reduce these barriers, but whether anonymity affects clinical outcomes is unclear. Objective This study compared an internet-bas...

Smart Coatings Integrating Antimicrobial and Tissue‐Remodeling Functions for Implant Interfaces

AIM: This study aimed to assess the antimicrobial performance and biocompatibility of our drug delivery platform, based on layer-by-layer (LbL) coating incorporating tetracycline (TC) complexed with anionic β-cyclodextrin (TCβCD) and a pH-responsive poly(methacrylic acid) (PMAA)...

Neurological paraneoplastic syndromes in patients with breast and gynecological cancer—a case series and structured literature review

Abstract Purpose Neurological paraneoplastic syndromes (PNS) occur in less than 1% of patients with cancer but carry a significant clinical burden. Prognosis strongly depends on timely diagnosis and treatment. This study presents an illustrative case series and a structured revie...

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Abstract Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood fac...

Glacier retreat shapes organic nutrient availability across lake succession

Glacier retreat is rapidly transforming landscapes, creating thousands of new lakes that act as natural laboratories of ecological succession. In these newly formed ecosystems, colonizing animals must meet their requirements for essential organic nutrients, such as long-chain pol...

Policy (dis)integration in water management: a historical analysis of a Swiss case

Abstract Over the past 170 years, water management in Switzerland has undergone a profound transformation. What began as a localized, event-driven practice shaped by immediate needs and local initiative—such as efforts to ensure flood protection—gradually evolved into a complex,...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Using long-axial field-of-view dynamic PET/CT data to generate synthetic contrast enhanced CT images

ABSTRACT Purpose Dynamic whole-body [ 18 F]FDG PET/CT (DWB-PET/CT) imaging performed on long-axial field-of-view (LAFOV) systems enables the simultaneous assessment of tracer delivery and metabolism across extended anatomical regions. We investigated whether tracer delivery infor...

The German media debate on taxing meat and other animal-based foods: a framing analysis

OBJECTIVE: Consumption of meat - red and processed meat in particular - exceeds recommended levels in most high-income countries. Higher taxes on meat have been proposed as a response, but have proven difficult to implement due to political controversy. We examined the role of fr...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

MicroRNAs as Biomarkers for Adenomyosis: A Systematic Review

Background/Objectives: Adenomyosis is a chronic gynecological disorder characterized by the presence of endometrial tissue within the myometrium, causing pelvic pain, abnormal uterine bleeding, and infertility. Despite its high prevalence, the molecular mechanisms underlying dise...

Effectiveness of the Active School quasi-experimental cluster-controlled trial: Impact on objectively measured physical activity in Swiss secondary school students after 12 months

Abstract Background Swiss adolescents exhibit insufficient physical activity (PA), with most not meeting daily and school-based PA recommendations, and girls being less active than boys. Comprehensive school programs promoting PA across multiple school segments, supported by trai...

Factors influencing female physicians’ careers in the German-speaking part of Switzerland

Despite an increase in female physicians in Swiss hospitals, most executive positions are still held by male physicians. This study aimed to identify obstacles and institutional factors influencing female physicians' careers and to evaluate ways to support their professional adva...

Effectiveness of Simulation-Based Training for Thoracentesis - A Systematic Review and Meta-Analysis

BACKGROUND: Thoracentesis is a common bedside procedure. Complication rates are, among other factors, associated with the clinicians' skills. Simulation-based training (SBT) for teaching procedural skills is widely recommended in medical education. However, the current evidence o...

HMGB1 expression in CT26 murine cancer cells modulates the tumor microenvironment and limits local anti-tumor immunity

Abstract High mobility group box protein 1 (HMGB1) is a ubiquitous protein that has multiple functions in the nucleus and cytosol. Following release into the extracellular space, HMGB1 acts as a mediator of inflammation. HMGB1 is overexpressed in many cancers and has both oncogen...

Physical activity participation in wheelchair sports groups: analysis of individual, interpersonal and club-related characteristics among individuals with physical disabilities

Abstract Background Physical activity is vital for individuals with physical disabilities, yet participation in organized sport remains low even though it significantly promotes physical and mental health, as well as social participation. This study applies a social-ecological mo...

Empagliflozin in GSD-Ib: Long-term safety and sustained recovery of neutrophil function including NET formation

Glycogen storage disease type Ib (GSD-Ib) engenders neutropenia and severe neutrophil dysfunction, leading to recurrent infections and inflammatory complications. Recent studies have identified intracellular accumulation of 1,5-anhydroglucitol-6-phosphate (1,5-AG6P) as a key mech...

Diabetes Mellitus and Long-Distance Running: A Systematic Review

BACKGROUND: Athletes with diabetes increasingly participate in endurance running, benefiting from physiological adaptations and technological advances like continuous glucose monitoring (CGM) for glycemic control. So far, no comprehensive review summarizing the current knowledge...