University of Bern

Characterizing tree species richness in Indigenous Peoples’ lands: addressing often-overlooked data limitations and biases

Abstract Several studies have characterized species richness distribution in Indigenous Peoples’ Lands (IPL) using global biodiversity datasets. However, these datasets contain substantial limitations and biases which may compromise the accuracy of spatial biodiversity assessment...

Clinical Behaviour and Outcome of Pelvic Osteosarcoma in Dogs: A Retrospective Multicentre Analysis of 74 Cases (2007–2025)

Although osteosarcoma is the most common primary bone tumour in dogs, involvement of the pelvic bones is rare. The aim of the present study was to describe clinical presentation, identify possible prognostic factors, and evaluate outcomes in dogs diagnosed with pelvic osteosarcom...

Diketopyrrolopyrrole‐Based Cation as a Semiconducting Spacer in Layered Perovskite

ABSTRACT Incorporating π‐conjugated organic spacers in layered “2D” perovskites in order to extend solar light harvesting has remained a challenge, as typically‐incorporated spacers (e.g. phenethylammonium, PEA + ) do not absorb deep into the visible spectrum. Here, we introduce...

Tracking funding disparities in global health aid with machine learning

Abstract Reducing the global burden of disease is crucial for improving health outcomes. However, misalignment between health aid and country-level disease burden leaves vulnerable populations without the necessary support for major health challenges, particularly in the least de...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

Intraarterial Thrombolysis: Past, Present, Future

Suboptimal clinical outcomes are common after ischemic stroke with large vessel occlusion despite current reperfusion treatment with intravenous thrombolysis and mechanical thrombectomy. Targeting residual distal arterial and microvascular occlusions with intraarterial thrombolys...

Quantitative MRI Susceptibility: Mapping of Transient Ischemic Attack—A Preliminary Study

A transient ischemic attack (TIA) is a transient episode of neurological dysfunction without evidence of acute infarct demarcation on neuroimaging. The radiographic features of TIAs are uncertain, as since there is currently no perfect imaging method with which to differentiate a...

Predictive Processing in Sport and Exercise Science: A Scoping Review and Theoretical Overview

Abstract Background This scoping review explored the application of predictive processing in sport and exercise science, examining how cognitive and computational models have been used to understand perceptual-motor skills, decision-making, and physical performance. The review pr...

Awake Prone Positioning in Moderate ARDS: A Case Report

Background: Legionella pneumophila is a rare but severe cause of community-acquired pneumonia and can lead to acute respiratory distress syndrome (ARDS). Awake prone positioning (APP) has been recognized as an effective adjunct for non-intubated patients with hypoxemic respirator...

Orthogeriatric Fracture Syndrome: Time Is Mobility!

Bissoto et al [...]

Multicystic renal dysplasia with ureteral anomaly and arteritis in a C3-deficient mouse

/J (C3 knockout) mouse presented with abdominal distension and reduced general condition. The animal was euthanized and submitted for necropsy. Gross examination revealed marked dilation of the left kidney and ureter, both containing clear fluid consistent with urine and a focal...

Current Use, Monitoring and Reversal of Neuromuscular Block in Pediatric Anesthesia and Intensive Care: A Web‐Based Cross‐Sectional ESAIC Survey

BACKGROUND: Neuromuscular blocking agents are recommended by the European Society of Anaesthesiology and Intensive Care (ESAIC) and European Society of Paediatric Anaesthesia (ESPA) for facilitating tracheal intubation in children. Despite these recommendations, real-world data o...

A multi-factor machine learning model for predicting and characterizing clinical trial failures

Abstract Background About 15% of clinical trials terminate prematurely (fail), causing financial losses and delaying treatment development. Methods This study utilized a subset of interventional trial records from the 471,252 studies registered in ClinicalTrials.gov until Novembe...

Examining smartphone-assessed executive function metrics and intrinsic resting-state functional connectivity in depression

<title>Abstract</title> Major Depressive Disorder (MDD) is a common and costly mental health condition that is often associated with deficits in executive function. Smartphone applications (“apps”) have emerged as promising methods for assessing mental health-related outcomes in...

European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines for antimicrobial and non-steroidal anti-inflammatory drug use in bovine respiratory disease

<ns5:p> Background Bovine respiratory disease (BRD) is a major cause of morbidity, mortality, impaired welfare, production loss, and antimicrobial use in cattle. These European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines provide evidence-based...

Teaching Signal Synchronization in Deep Neural Networks with Prospective Neurons

Abstract Working memory requires the brain to maintain information from the recent past to guide ongoing behavior. Neurons can contribute to this capacity by slowly integrating their inputs over time, creating persistent activity that outlasts the original stimulus. However, when...

Tumour Volume Independently Predicts Metastasis in ISUP 2 Prostate Cancer

Background and Objectives: The outcomes for patients with localised prostate cancer are variable, even within defined tumour grades or clinical risk groups. Identifying features associated with disease aggression is imperative in contemporary PCa research. ISUP 2 PCa is particula...

A joint geophysical-geochemical deep-mantle zoning map beneath East Africa and the Indian Ocean

Geochemical signatures of hotspot lavas suggest that their mantle sources are compositionally distinct, but their source locations remain elusive. Mapping hotspots to their deep origins is complicated by the presence of interconnected, low–seismic velocity networks in the mantle,...

Validation of the AO Spine Osteoporotic Fracture Classification—effect of geographical region on reliability and reproducibility

Regional differences affect the reliability of the AO Spine-DGOU Osteoporotic Fracture Classification. European participants showed the highest agreement. This study underscores the need for addressing regional factors to improve the system’s global clinical utility. To evaluate...

Idylla™ POLE-POLD1 mutation assay for molecular characterization and risk stratification of endometrial cancers: a retrospective multicenter validation study

Endometrial carcinoma (EC) is a common gynecological cancer with rising incidence driven by obesity and aging populations. Accurate and timely molecular classification is critical for guiding personalized oncology treatment, especially in early-stage high-grade endometrioid carci...