University College London

Awake craniotomy for drug-resistant non-oncological epilepsy: a systematic review of feasibility, reported safety, and seizure outcomes

Abstract Introduction Complete resection of the epileptogenic zone offers the best chance of seizure control in patients with drug-resistant epilepsy. However, surgical management remains challenging when the epileptogenic zone is located within or adjacent to eloquent brain regi...

Automatic value learning results in counterproductive human behavior

Abstract Humans are adept at accurately estimating the value of available choices from accumulated experience. However, cognitive processing also incorporates irrelevant information during deliberation, undermining decision accuracy. Here, we show that credit assignment operates...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

Exploring new measures of accuracy in second language task-based spoken performance

Abstract This article focuses upon the measurement of accuracy in second-language task-based spoken performance, with measures related to unit of analysis, error gravity, and accuracy linked to clause length. Building on established indices, three new measures of accuracy, all li...

The Co-Occurrence of Postural Orthostatic Tachycardia and Functional Neurological Disorder: A Meta-Analysis and Narrative Synthesis

Background: Functional Neurological Disorder (FND) and Postural Orthostatic Tachycardia Syndrome (POTS) are both complex, often debilitating conditions that frequently affect young women and involve high symptom burdens and psychiatric comorbidity. Although clinical overlap betwe...

Early Longitudinal Brain Network Changes in Huntington's Disease Before Clinical Motor Onset

Abstract Background Longitudinal studies of seed‐based functional connectivity (SBFC) in young adult Huntington's disease gene‐expanded (HDGE) individuals are rare, and none, to our knowledge, have examined adult cohorts decades from predicted clinical motor diagnosis. Objectives...

Where Does the City Grow? Residual Floor Area and the Determinants of Residential (Re)development in São Paulo

Using a novel block-level dataset covering all residential (re)developments in São Paulo, this paper examines why some blocks are (re)developed while others are not. Consistent with development-viability theory, the results show that blocks with greater residual development poten...

Associations Between Dissociation and Childhood Trauma in Borderline Personality Disorder and Affective Disorders: A Network Analytic Approach

ABSTRACT Background Dissociation and childhood trauma are strongly associated with borderline personality disorder (BPD), yet it remains unclear whether this reflects disorder‐specific mechanisms or differences in symptom severity within a shared transdiagnostic structure. Object...

Frailty before disease onset: risk of mortality and chronic conditions in disease-free middle-aged adults

Abstract Frailty, defined by multisystem physiological decline and heightened vulnerability to stressors, is typically associated with aging and chronic disease. However, its relevance in apparently healthy individuals remains poorly understood. Identifying frailty in this popula...

Stigma, discrimination-related events, and determinants among adult people living with systemic lupus erythematosus (SLE): Systematic review and indicator-level meta-analysis

BackgroundSystemic lupus erythematosus (SLE) is a complex autoimmune disease with 0.4 million new cases diagnosed annually. With its wide variety of visible and invisible manifestations, people living with SLE report being exposed to stigmatization, which impacts their personal a...

Technological variability in Etruscan amphora production at Vulci: Evidence from petrographic and compositional analysis

This study investigates the production of Etruscan transport amphorae from Vulci (central Italy) through an integrated programme of ceramic petrography and bulk compositional analysis (ICP-MS). A total of 48 amphora samples, collected during two sampling campaigns (2021 and 2023)...

Post-diagnostic support for dementia in the UK: mapping access, delivery and gaps in provision

Abstract Background Dementia is a progressive condition affecting approximately 982,000 people in the UK, with substantial implications for people living with dementia, carers, and healthcare systems. Effective post-diagnostic support is essential for managing symptoms and mainta...

Pho84/GLUT2 are cellular myo-inositol exporters regulated by inositol pyrophosphates

Abstract Inositol is an essential nutrient for most living organisms, as combinatorial phosphorylation on this cyclic sugar generates key cellular messengers, such as lipid-bound phosphoinositides (PtdInsPs), water-soluble inositol phosphates (InsPs), and high-energy inositol pyr...

Fluid Toxicities: Violent Affective Ecologies in Cartagena, Colombia

ABSTRACT Water is at the centre of climate change emergency concerns in coastal cities. It constitutes here a fluid entry point to investigating the socio‐ecological politics of toxicities for residents dwelling with and against contaminated waters in Cartagena, Colombia's urban...

Sample-efficient and generalizable velocity and pressure field reconstruction from three-dimensional two-phase flow interfaces

Abstract Accurate reconstruction of velocity and pressure fields from gas-liquid interfaces is essential for quantifying two-phase flow dynamics and enabling real-time flow visualization and diagnostics. This study presents a Transformer-based neural operator model pretrained on...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Improved building performance prediction model based on the OODA-MDOB approach

Abstract The neglect of subjective factors such as cost consideration and accessibility in occupant behavior models leads to unrealistic device usage simulations, which ultimately undermines prediction accuracy. To address this gap, this paper proposes a Multi-Device Occupant Beh...

Theoretical study into a novel design of oscillating water column with high broadbanded efficiency

This paper considers the theoretical operation of a novel wall-mounted oscillating water column wave energy device designed to be resonant over a broad range of frequencies. A curved duct with a submerged opening in a vertical wall is partitioned into a number of separate narrow...

A topology of digitalising territories

This paper develops a topological analysis of digitalising territories which examines the dynamic relationship between territory, land, and the digital technologies of measurement and control. We propose a conceptualisation of digitalising territories through a topological lens a...

Moral identity and language jointly influence how bilinguals feel and decide

Abstract This preregistered study investigated how moral identity relates to moral decisions and emotional responses in 106 Greek–English bilinguals. Participants evaluated two sacrificial-harm and two honesty-based interpersonal moral dilemmas and completed the Moral Identity Qu...