University College London

Element-Specific DonorNumbers for Anions

Abstract Anion interactions with cations/molecules are crucial across chemistry and biology: in battery electrolytes, synthesis, atmospheric processes, and protein denaturation. Selecting the optimum anion represents an immense challenge, as anion interactions are diverse and com...

Spatially Explicit Optimal Decarbonization Pathways for China’s Cement Industry

Abstract Cement production contributes about 8% of global CO2 emissions, but conventional assessments often overlook spatiotemporal heterogeneity in demand, energy resources, infrastructure, and policy constraints. This study develops a high-resolution whole-system optimization f...

Political Economy of Manchesterism

ABSTRACT This paper presents an intellectual history of Manchesterism. It explains the ruling ideas that have shaped the recent development of Greater Manchester and critically assesses their application. It pays particular attention to the evolution of inequality in Greater Manc...

Thromboxane A2-Driven Vascular Hyperreactivity in Cadmium-Induced Hypertension: Role of Oxidative Stress and Therapeutic Implications

Background/Objectives: Environmental factors, including heavy metals such as cadmium, are increasingly recognized as important contributors to hypertension beyond traditional risk factors. To date, the role of angiotensin and alpha-adrenergic receptors in hypertension induced by...

Developing a scalable pipeline for data extraction from clinical letters through resource-efficient prompt engineering

<title>Abstract</title> Free-text clinical records represent an untapped wealth of data for secondary use. Their potential is limited by resource demands necessary for accurate information extraction at scale. We introduce a scalable, resource-efficient, and high-performance pipe...

COPI Coatomer Regulates Several Steps of HDL Metabolism

Abstract Background Reverse cholesterol transport by high density lipoproteins (HDL) is considered as an anti-atherogenic metabolic pathway. Hepatocytes determine the efficacy of this pathway by the production of apolipoprotein A-I (apoA-I) and its lipidation by ATP binding casse...

Do's and Don'ts in Peace Negotiations: Learning From the Arab‐Israeli Peace Negotiations

ABSTRACT This article suggests practical information on the requirements for successful negotiations. Building on extensive research in archives and more than 100 in‐depth interviews with senior decision‐makers and negotiators who were involved in the Arab‐Israeli conflict, the a...

Deep generative model for human mobility behavior

Understanding and modeling human mobility is central to challenges in transport planning, sustainable urban design, and public health. Despite decades of effort, simulating individual mobility remains challenging because of its complex, context-dependent, and exploratory nature....

Distribution of device-measured 24-hour movement behaviours across the cognitive spectrum in older adults: the HUNT study

Abstract Background Key daily physical activities (e.g., standing and walking), postures (sitting and lying), and sleep constitute the 24-h day and have distinct health effects and functional implications. Traditionally studied separately, the distribution of these movement behav...

Non-solvating additives regulate zinc deposition through anion-gated Stern-layer competition

Abstract While additive-induced modulation of solvation structure has emerged as an effective strategy to enhance the performance of aqueous zinc-ion batteries, the electrochemical mechanisms by which non-solvation additives interact with ion species within the electric double la...

Genetic clusters of BMI reveal symptom-specific causal effects on depression

Abstract While BMI is phenotypically and genetically associated with depression, the extent to which BMI causes depression and the mechanisms underlying this effect remain unclear. We estimated the causal effect of BMI on depression symptoms, accounting for complexity in both the...

Fostering reflection: Development and initial evaluation of a mentalization-based GenAI simulator for foster care supervisors

Background Foster care supervisors require advanced reflective functioning (RF) to manage complex relational demands, yet traditional training is difficult to scale and access. Generative AI (GenAI) may help by enabling simulated practice environments. Objective This feasibility...

Pedagogy in the speech-gesture couplings of caregivers: Evidence from a corpus-based analysis

In face-to-face communication, representational gestures-imagistically evoking properties of referents-support both language comprehension and development. In adult-adult interaction, representational gestures are systematically produced before the words they are semantically rel...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

Tear Cytokine Signature in Vernal Keratoconjunctivitis: A Chemokine-Remodeling Axis Associated with Disease Severity

Vernal keratoconjunctivitis (VKC) is a chronic pediatric ocular allergy that can progress from seasonal to persistent inflammation with vision-threatening complications. Although Th2-associated mechanisms have been implicated, the immune correlates of disease severity are not wel...

Defining global priorities in hematopoietic transplantation and cellular therapy: a statement paper from EBMT Global ComMittee

Abstract Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income co...

Does the AMPD1 C34T Polymorphism Influence Physical Performance in Elite Athletes?

Background/Objectives: Adenosine monophosphate deaminase deficiency has been implicated in impaired exercise capacity. We examined whether the AMPD1 C34T (rs17602729) genotype was associated with athlete status and performance in distance runners (DR) and rugby union (RU) athlete...

Deciphering the Roleof Hydrophobic Amino Acid l -Methionine in Tuning CO2 Hydrate Kinetics:Insights from Molecular Dynamics Simulations

Abstract CO2 clathrate hydrate has emerged as a promising medium for carbon sequestration owing to its exceptionally high CO2 storage capacity and intrinsic stability in subsea environments. Sluggish growth kinetics hinder its field application and large-scale deployment. The hyd...

“The university is the foundation of ethics”: Views of postgraduate students on an MA Education course towards research ethics

Scholarship has emphasised the importance of teaching research ethics within the university context, yet also highlights the challenges involved. Two key barriers may be identified: the conceptualisation of research ethics, and the language found on applications for ethical appro...

Tell Your Story: Strengthening Scientific Engagement and Welfare Leadership among Animal Technologists

<ns5:p>Background Animal Technologists (ATs) are vital in the scientific community, offering crucial expertise in animal care, welfare, and experimental procedures. As projects become more complex, there is an increasing opportunity for ATs to engage actively in scientific projec...