University College London

Immune control of HIV viraemia in early paediatric infection is associated with induction of HIV-specific CD8+ T-cell activity following multiple treatment interruptions

BACKGROUND: Virus-specific CD8+ T-cells play an important part in HIV cure/remission in adults, yet their role in paediatric immune control is limited by tolerogenic early-life immunity. Very-early ART initiation, while effective in restricting viral reservoir size, also prevents...

Vitamin C-Incorporated Polycaprolactone Membranes Enhance Angiogenic–Osteogenic Coupling by Modulating Oxidative Stress In Vitro

The study investigates the influence of vitamin C-incorporated polycaprolactone (PCL-Vit C) membrane in scavenging reactive oxygen species (ROS) and enhancing angiogenic–osteogenic coupling in vitro. Human umbilical vein endothelial cells and human fetal osteoblast cells were co-...

The magnetic field in M16: new results from the JCMT BISTRO survey

Abstract We present a study of the magnetic field (B-field) in the Eagle Nebula (M16) using data from the James Clerk Maxwell Telescope (JCMT) B-fields In STar-forming Region Observations (BISTRO) survey. We extend our previous study of the well-known ‘Pillars of Creation’ region...

National multi-specialty robotic surgery training curriculum and implementation for UK surgical residents: a delphi consensus

Abstract Robotic-assisted surgery is now established across multiple surgical specialties in the United Kingdom, yet training for surgical residents remains variable, resource-dependent, and insufficiently standardised at national level. This study sought multispecialty expert co...

Driven to succeed? Teenagers’ achievement motivation, university aspirations, and performance on high-stakes examinations

Abstract There is growing interest in how young people’s socio-emotional skills, particularly motivation, shape educational outcomes. Yet less is known about how adolescents’ general achievement motivation and their specific aspirations to attend university relate to performance...

Classifications of Substorms With MLT Patterns of SMU‐SML Indices Based on Convection Properties

Abstract During substorms, magnetospheric convection and magnetotail current sheet disturbances are two critical processes, both driving ionospheric electrojets. Dusk‐side SMU and dawn‐side SML (SuperMAG Electrojet indices) enhancements reflect two‐cell convection. Using this rel...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

Archeological theory and AI: the potential past through agentic systems

Abstract The increasing capabilities of AI in automation and integration within existing methodology present a new opportunity for disciplines to address long-standing theoretical challenges. This is evident in archaeology, where persistent theoretical debates and interpretive va...

Multimodal fusion of complementary material representations for generalizable and interpretable property prediction

Material properties often depend on coupled compositional, structural, and geometric factors that are incompletely captured by any single representation. We introduce interpretable multimodal fusion (IM-Fuse), a framework that integrates compositional descriptors, crystal graphs,...

Are Group Interventions Effective at Improving Health Outcomes in Culturally And Linguistically Diverse (CALD) Populations With Chronic Conditions? An Umbrella Review

Abstract Culturally and linguistically diverse (CALD) populations experience disproportionate burdens of chronic disease compared to the general population; previous research demonstrated group-based interventions improve health outcomes across various chronic conditions. This um...

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...

Pharmacological Inhibition of Small Extracellular Vesicle Secretion by ALK5i SD‐208 via Lysosomal Rerouting of CD63+ Compartments

ABSTRACT Pharmacological tools to selectively modulate extracellular vesicle (EV) secretion are scarce. Here, we identify the ALK5 (TGF‐β receptor I) inhibitor SD‐208 as a potent suppressor of small EV (sEV) secretion that acts independently of its canonical anti‐fibrotic activit...

Correlated Polymer‐Proton Hopping Enables Water‐Independent Fast Proton Transport in Poly(Ionic Liquid) Membranes

Polymer electrolyte membranes composed of ionic liquids (IL), capable of conducting protons efficiently at elevated temperatures, without external humidification, could transform fuel cell technology. However, the molecular origins of such proton transport remain poorly understoo...

Autism and attention-deficit/hyperactivity disorder traits as predictors of tic phenomenology in children and adolescents

Abstract The co-existence of autism and attention deficit/hyperactivity disorder in tic disorders is a key factor influencing clinical decision-making. Given the shared clinical features and a potentially overlapping aetiology, the need to identify specific tic characteristics as...

Social robots and future crime: a scoping literature review

Abstract Purpose Social robots are set to permeate every area of our lives from childhood, well into our old age—from education, policing, and entertainment, to healthcare. Ensuring that their deployment happens in a safe and secure way requires a firm understanding of the broad...

Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment. Aficamten is a cardiac myosin inhibitor targeting excess contractility and diastolic impairment, the predominant mechanism responsible for adverse ou...

When habit prevails: a causal test of policy feedback theory using a pension reform

Abstract Elderly voters are a growing, politically powerful electoral bloc, and their pensions often constitute the largest component of welfare state. We know that cuts can provoke electoral backlash, but it is less clear whether benefit expansions mobilize retirees. Some policy...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Minimally verbal status in children with intellectual disability of genetic origin – prevalence, functional impact and relationship with motor skills: evidence from the IMAGINE-ID cohort

Abstract Background Up to a third of autistic children do not develop functional speech and remain minimally verbal (MV) beyond the age of 5, yet little is known about the clinical characteristics of this group. Less still is known about the prevalence or impact of MV status in c...

The Psychoses : Jacques Lacan’s Seminar III (1955–1956)

SUMMARY During the academic year 1955–1956, Jacques Lacan, a prominent psychiatrist and psychoanalyst, delivered his third seminar in Paris. Seventy years later it remains little known among psychiatrists in the UK. Seminar III was devoted to the psychoses, particularly the delus...