University College London

Reducing Emotional Burden Carried by Neurodivergent Students in School: Perspectives From Students and School Staff

Abstract Purpose Compared to neurotypical peers, neurodivergent students experience increased exposure and more intense responses to commonly upsetting events (emotional burden), contributing to poor mental health. Student and staff perspectives offer insights into sources of emo...

Intra-abdominal Bowel Dilation in Experimental Gastroschisis Is Associated With a Modifiable Transcriptomic Program of Intestinal Dysfunction

OBJECTIVE: To characterize intestinal transcriptional profiles in gastroschisis, their temporal evolution, and response to fetal intervention. SUMMARY BACKGROUND DATA: Gastroschisis causes significant intestinal dysfunction, with intra-abdominal bowel dilation clinically shown to...

Bounded diameter monochromatic component covers

Abstract Ryser conjectured that every ‐edge‐coloured complete graph can be covered by monochromatic trees. Motivated by a question of Austin in analysis, Milićević predicted something stronger — that every ‐edge‐coloured complete graph can be covered by monochromatic trees of bou...

Opting in instead of opting out: an open-ended, arts-based workshop method for exploring refugees' experiences of disasters

Purpose Arts-based research has received growing interest and is suggested to be appropriate for sensitive topics or working with vulnerable people. This article explores the use of a multi-arts-based workshop, as an open enquiry approach, to explore refugees' experiences of disa...

Trade-Offs Between Ranking Objectives: Descriptive Evidence and Structural Estimation

When designing product rankings, online retailers and platforms choose which outcome to maximize: revenues from commissions or markups, the number of transactions, or consumer welfare. These objectives need not align, creating potential trade-offs. This paper studies how rankings...

Why Is the Mental Health of the Youngest American Workers in Decline?

The worsening mental health of young workers drives what appeared to be the disappearance of the age-related U-shape in wellbeing and the hump-shape in illbeing over the last decade. Using repeat cross-sectional data, we show that, whilst illbeing remains hump-shaped among non-wo...

Practitioner psychologists’ experiences of delivering a cognitive behavioural therapy informed crisis intervention for psychosis in inpatient settings: a mixed methods investigation within the CRISIS study

Abstract Objectives Cognitive behaviour therapy for psychosis (CBTp) should be delivered in psychiatric inpatient settings, yet little is known about therapists’ perspectives on delivering it. This study examined therapists’ perspectives on delivering a crisis-focused CBTp-inform...

Digital exclusion and health in older adults: a systematic review

Abstract Healthcare systems are turning increasingly digital. Digital exclusion restricts access to a wider range of health-related resources among older adults, which delays prevention and treatment, posing additional health challenges. The study aims to systematically review th...

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...

A Machine Learning Platform for Imputing Missing Critical Quality Attributes in Pharmaceutical Development

Quality control is fundamental to drug development, with critical quality attributes (CQAs) serving as key indicators of product performance. However, missing or incomplete CQA data remains a persistent challenge throughout pharmaceutical research and manufacturing. In this study...

Development of a chemometric platform for mid-infrared fermentation monitoring

<title>Abstract</title> Industrial bioprocess development still depends heavily on off-line analytics such as HPLC, which, while accurate, are slow and limit real-time decision-making. Process Analytical Technologies (PAT) can overcome this barrier, with mid-infrared spectroscopy...

Facilitating megacity electricity decarbonization via grid-interactive demand-side resource management

City power systems face intensified mismatches between generation and dynamic demand under rising zero-carbon energy penetration levels. Although demand-side resource management offers mismatch mitigation potential by regulating load patterns, its city-level capability remains un...

Beta-lactam antibiotics have immunomodulatory effects in vitro, including changes consistent with sepsis-induced immunosuppression

Abstract Introduction Sepsis is associated with immunosuppression, predisposing patients to secondary infections. Many treatments routinely used for infections have immunomodulatory effects, including antibiotics. We therefore assessed the immunomodulatory effects of beta-lactam...

Fullerene‐Mediated Iodine Immobilization at Buried Interfaces in Sn–Pb Perovskite Solar Cells

ABSTRACT Narrow‐bandgap perovskite solar cells (PSCs) are promising absorbers for tandem photovoltaics; however, their performance remains limited by interfacial recombination and instability, particularly Sn 2+ oxidation and halide‐related degradation. Although fullerene derivat...

Collaborative optimization framework of battery charging/swapping stations for eVTOLs based on closed-loop supply chain and space-time network

Electric vertical take-off and landing (eVTOL) aircraft, by virtue of their advantages such as high efficiency, environmental friendliness, and low noise, are regarded as an effective means of alleviating urban traffic congestion. Although eVTOLs have policy support, industrial f...

MultipathwayAggregation Drives Concentration-DependentAmyloid Polymorphism and Time-Dependent Morphological Evolution

Abstract Amyloid aggregation into polymorphic fibrils is central to many neurodegenerative and systemic diseases, yet the physical origins of fibril polymorphism and time-dependent morphological evolution remain unclear. Because mature fibril morphologies are separated by high en...

Data-Driven Fatigue Trajectories in Multiple Sclerosis and Their Predictors

Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), yet its longitudinal trajectories and determinants remain poorly characterized. We aimed to identify trajectories of cognitive and physical fatigue in relapsing-remitting MS (RRMS) and to determine baseline...

Defining ‘psychedelic’

Humphry Osmond coined the term ‘psychedelic’ in 1956, conjoining ‘psyche’ for ‘soul’ and ‘delic’ for ‘to manifest’ or ‘illuminate’. Soul-illumination is a compound noun that describes a psychological state or process. Osmond intended for it to be a taxonomic noun—naming, not just...

Comprehensive benchmarking of machine learning methods for risk prediction modelling from large-scale survival data: a UK Biobank study

Predictive modelling is vital to guide the prevention of incident disease (e.g., risk-based initiation of preventive pharmacotherapies). Whilst large-scale prospective cohort studies and a diverse toolkit of available machine learning (ML) algorithms have facilitated such surviva...

4000-year-old painted plaque from Southeast Indonesia reveals Austronesian Painting Tradition preceded Neolithic pottery

The Austronesian dispersal is the largest such event in human history, with descendants of people from Taiwan colonizing islands from Rapa Nui to Madagascar. The extent to which this dispersal was facilitated by an economic package or a particular ideology is uncertain. The “Aust...