Université Paris Cité

Performance of the iBox Prognostication System in African American Kidney Transplant Recipients

Background: The iBox is a validated prognostication system that predicts long-term death-censored graft loss in kidney transplant recipients, but its performance in the specific population of African American recipients has not been fully studied. Methods: We conducted a multicen...

Cefepime exposure in prolonged or intermittent infusion in critically ill children

Aims Cefepime is commonly used in critically ill children for whom there is a high between‐subject variability. To reach the therapeutic pharmacokinetic (PK) target in critically ill patients, prolonged infusion of beta‐lactams seems to be the most efficient. The aim of this stud...

The parent bodies of Ryugu and Ivuna formed before those of other carbonaceous chondrites

Most carbonaceous chondrite (CC) meteorites contain abundant chondrules, millimeter-scale spherical inclusions of previously molten material. Ivuna-type carbonaceous chondrites (CIs) do not contain chondrules, nor do samples of the carbonaceous asteroid Ryugu. CIs and Ryugu share...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Weak-Strong Uniqueness for the Landau Equation by a Relative Entropy Method

Abstract. We derive a weak-strong uniqueness and stability principle for the Landau equation in the soft potentials case (including Coulomb interactions). The distance between two solutions is measured by their relative entropy, which to our knowledge was never used before in sta...

Mean-Field Limit for Stochastic Control Problems under State Constraint

Abstract. We study the convergence problem of mean-field control theory in the presence of state constraints and nondegenerate idiosyncratic noise. Our main result is the convergence of the value functions associated to stochastic control problems for many interacting particles s...

Deep learning recognises antibiotic modes of action from brightfield images

Abstract Antimicrobial resistance is a growing public health threat predicted to cause up to 10 million deaths a year by 2050. To circumvent existing bacterial resistance mechanisms, discovering antibiotics with novel modes of action (MoAs) is crucial. While growth inhibition ass...

Normal approximation for subgraph counts in age-dependent random connection models

Abstract We study normal approximation of subgraph counts in a model of spatial scale-free random networks known as the age-dependent random connection model . In the light-tailed regime where only moments of order left parenthesis 2 plus epsilon right parenthesis ( 2 + ε ) $(2+\...

Visual foraging and individual characteristics: Contribution of executive functions and personality

In exhaustive visual foraging tasks, in which observers select multiple instances of two target types, they change their strategy according to the task difficulty. During easy feature-based foraging, observers locate the nearest target and often switch between target types (proxi...

Biological Activities and In Silico Molecular Docking of an Aqueous Extract of Nigella sativa L. Seeds: A Focus on Antioxidant, Cytotoxic, and Diuretic Effects

Background: Nigella sativa L. is a medicinal plant widely recognized for its diverse pharmacological properties. This study aimed to evaluate the antioxidant, diuretic, and cytotoxic effects of an aqueous seed extract and its effects on selected biochemical parameters in rats. Th...

Factors influencing access to healthcare for the indigent in Senegal

Equitable access to health services remains a major challenge to achieving universal health coverage (UHC). In Senegal, the National Family Safety Net Program (PNBSF) aims to reduce vulnerability among poor households through cash transfers and free enrolment in community-based h...

Effect of oxygen ion irradiation on the visible, infrared, and Raman spectra of Phobos candidate materials: implications on the space weathering by Martian atmosphere-derived ions

Abstract The origin of Martian satellites is still under debate. Nevertheless, such information could give insights into the evolution of the Martian system and planetary formation processes. To address these questions, MMX (Martian Moons eXploration) will conduct spectroscopy (v...

Antifibrotic therapy in patients with pleuroparenchymal fibroelastosis: a multicentric observational study

Pleuroparenchymal fibroelastosis (PPFE) is a rare interstitial lung disease characterized by upper-lobe predominant pleural and subpleural fibrosis and associated with poor prognosis. No evidence-based medical therapy is currently established, and lung transplantation remains the...

Beyond the standardization trap: A critical quantitative perspective on disabilities across transit and public spaces

In recent years, there has been renewed interest in the discrepancies between conceived and perceived accessibility. A particularly recurrent critique of accessibility as conceived through planning and measurement standards is that it tends to misjudge the actual difficulties exp...

Proofs and Derivations for the Math Journey to Black-Scholes, Greeks and Beyond

This companion volume provides complete, rigorous proofs for every result statedin "Math Journey to Black-Scholes, Greeks and Beyond: An Extended Exposition."Part I proves the measure-theoretic and stochastic-calculus foundations, fromJensen's inequality and the Radon-Nikodym the...

Math Journey to Black-Scholes, Greeks and Beyond: An Extended Exposition

This is a self-contained, graduate-level exposition tracing the path fromelementary probability to modern option pricing. Every model is built from itsmathematical foundations, every formula is derived, and every assumption isstated and examined. Part I develops the complete theo...

Math Journey to Black-Scholes, Greeks and Beyond: An Extended Exposition

This is a self-contained, graduate-level exposition tracing the path fromelementary probability to modern option pricing. Every model is built from itsmathematical foundations, every formula is derived, and every assumption isstated and examined. Part I develops the complete theo...

Workflow management systems and reproducible pipelines for Plasmodium falciparum genomic surveillance: tools, design principles and infrastructure challenges

Genomic data are increasingly leveraged to enable malaria genomic surveillance, with many teams now generating Plasmodium falciparum sequence data for routine analysis. However, downstream analysis remains dependent on ad-hoc scripts and local infrastructure. This reliance limits...

The 1H, 15N and 13C backbone resonance assignments of an intrinsically disordered region (467–696) of breast cancer type 1 susceptibility protein (BRCA1)

The tumor suppressor protein breast cancer type 1 susceptibility protein (BRCA1) plays a central role in maintaining genome stability through its involvement in DNA damage repair, transcriptional regulation, and cell-cycle control. BRCA1 functions as an obligate heterodimer with...

Electrophysiological profiling of exocytosis during early-stage development of the zebrafish lateral line

Abstract Hair cells of the zebrafish lateral line have proven to be a good model for studying hair cell function in a system that is easily genetically manipulated, rapidly develops and is experimentally accessible. However, characterization of potential developmental changes, an...