Université Paris Cité

Routing to the seizure in postoperative human glioma cortex: spatio-temporal uncoupling between slow and fast extracellular neuronal activities

Abstract Background Diffuse gliomas are frequently associated with epilepsy, particularly in low-grade variants. Seizures are key events to be considered in glioma management, including during surgery. Optimizing resection of epileptic areas may affect not only postoperative epil...

Transform-to-thrust reactivation of a fossil back-arc spreading system: Evidence from marine magnetic anomalies in the East Sea (Japan Sea)

Transform faults contain rheological weaknesses that can be reactivated into either divergent or convergent boundaries, depending on tectonic stress regime. While rifting triggered from transform fault is well documented, geophysical evidence demonstrating compressional reactivat...

DaiSy: A Library for Scalable Data Series Similarity Search

Exact similarity search over large collections of data series is a fundamental operation in modern applications, yet existing solutions are often fragmented, specialized, or tailored to specific execution environments. In this paper, we present DaiSy, a unified library for exact...

Integrating Drug Physicochemistry and Hfq-Dependent Regulation of Ciprofloxacin Accumulation in Escherichia coli

Ciprofloxacin (CIP), an amphoteric fluoroquinolone, undergoes pH-dependent changes in protonation state that influence membrane permeability and intracellular accumulation. Here, we investigated how drug physicochemistry and bacterial regulatory pathways jointly determine CIP acc...

Longitudinal Modeling of Cardiometabolic Dysfunction in Patients With Type 2 Diabetes Using Item Response Theory

ABSTRACT Cardiometabolic dysfunction in patients with type 2 diabetes (T2D) is reflected by multiple risk factors and cannot be fully characterized by any single biomarker. Item response theory (IRT) provides a framework for integrating observed risk factors into latent measures...

Primer: Functions and evolution of viral proteins

ABSTRACT Viruses encode an enormous variety of proteins that jointly comprise the largest pool of protein diversity on Earth. At coarse grain, the viral pan-proteome can be partitioned into four classes of proteins that differ in their evolutionary conservation, spread across the...

Energy expenditure of bonobos across their locomotor repertoire

Unlike quadrupedal mammals, primates use diverse locomotor modes adapted to arboreal environments. Such diversity of movements challenges allometric models, which underestimate energetic costs by focusing on steady-state walking. To address this, we combined ethological and biome...

Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury

BackgroundThe preferred method of renal-replacement therapy for acute kidney injury in critically ill patients remains uncertain. MethodsIn this multicenter, open-label, noninferiority trial, we randomly assigned critically ill adults with acute kidney injury who had indications...

Magnetic signatures in merger products

All template inlist files used to create the stellar models used in the 'Magnetic signatures in merger products' paper, as well as our additions to the 'run_star_extras.f90' file used to enable a nu_max-based stopping criterion. The single-star models were calculated based on the...

Cerebral No‐Reflow after Thrombectomy: International Delphi Consensus on Definition and Imaging Assessment

BACKGROUND: The operational definition and imaging assessment of the no-reflow phenomenon, a potential contributor to poor clinical outcome despite successful thrombectomy, remains debated. We aimed to develop expert-based international consensus on the definition, assessment, an...

Hackathon on predictive modelling in systems pharmacology: design, implementation, and outcomes

Background The growing availability of multi-omics data and machine learning methods creates both an opportunity and a challenge for the systems pharmacology community: the opportunity to model drug action at unprecedented mechanistic resolution, and the challenge of equipping a...

Early Pregnancy Use of Anti-CGRP Monoclonal Antibodies and Propranolol and Spontaneous Abortion Risk

Importance Migraine affects individuals of reproductive age, but treatment options during pregnancy are limited due to safety concerns. Anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) are effective for migraine prevention; however, CGRP is important in pl...

Electrophysiologic Demyelinating Features Are Common in Vasculitic Neuropathy: A Cohort of Biopsy‐Confirmed Cases

ABSTRACT Introduction/Aims Electrophysiologic features suggestive of demyelination have been reported in vasculitic neuropathy, complicating the diagnostic process, but their frequency is unknown. We aimed to determine the prevalence of demyelinating features, including fulfillme...

Efficacy and safety of temporary selective portal vein embolization before major hepatectomy (EMBORES): a phase 2 trial

Background Portal vein embolization (PVE) is routinely used before major hepatectomy to induce hypertrophy of the future liver remnant (FLR) and reduce post-hepatectomy liver failure. Conventional PVE relies on permanent embolic agents, resulting in irreversible portal occlusion,...

The enhanced capabilities of mid-infrared limb emission sounding to observe stratospheric aerosol injection geoengineering

Abstract. Using a model-based pseudo-reality (PR) future scenario and realistic pseudo-observations (POs) representative for a proposed satellite mission concept (CAIRT – the Changing-Atmosphere Infra-Red Tomography explorer), we analyse the capabilities of a high-spectral-resolu...

Synaptic vesicle undocking induces low-frequency depression

Abstract Synaptic depression is often interpreted as reflecting depletion of the readily releasable pool (RRP) following exocytosis. Such a mechanism predicts little or no depression at low stimulation frequency, as RRP replenishment should then offset the loss of vesicles by exo...

Sepsis in the major burn patient

Abstract Background Sepsis in the context of major burn injury presents a significant challenge to clinicians. It affects a substantial proportion of patients with major burn injury and is the leading cause of death in those that survive to hospital. Due to the complex and profou...

RENOVATE Healthcare Ireland & Ukraine: Economic protocol for comparative cost-effectiveness of available health interventions for depression, according to symptom severity

Background Depression is a leading cause of disability worldwide, associated with reduced quality-of-life and significant economic costs. While NICE has recommended first-line pharmacological, psychological and physical interventions for adults with less severe (subthreshold/mild...

MAC-explorer: bridging genome-based taxonomy and an identification tool for the Mycobacterium avium complex

The Mycobacterium avium complex (MAC) comprises genetically close nontuberculous mycobacteria responsible for human and animal infections worldwide. Increasing availability of whole-genome sequencing (WGS) data offers new opportunities for genomic surveillance and lineage trackin...

Phenolic Profiling and OECD-Guided Acute and Subacute Oral Toxicity Assessment of Cannabis sativa L. Seed Hydroethanolic Extract

Cannabis sativa L. seeds have been traditionally used in Moroccan folk medicine and are increasingly recognized as a valuable source of nutrients and bioactive phytochemicals with promising therapeutic properties. Despite their widespread traditional and nutritional use, scientif...