Université Paris Cité

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

Abstract Objective To assess the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) stratified by age, number of previously attempted antiseizure medications (ASMs), and SCN1A pathogenic variant status. Methods In this post hoc analysis, data from three ran...

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...

Cuproptosis: an emerging member of the immunogenic cell death family

Cell death was long considered the terminal consequence of cellular stress or damage, and distinct cell death modalities were classified according to their molecular execution mechanisms rather than their immunological impact [ 1 , 2 ]. This reductionist view has progressively be...

Constitutive natural killer cell features associated with post-treatment control of SIV infection in the pVISCONTI study

Abstract Post-treatment HIV controllers (PTC) offer a unique opportunity to uncover the determinants of durable remission after antiretroviral therapy (ART) interruption. Here, using six PTC and six post-treatment non-controllers from the pVISCONTI study in cynomolgus macaques, w...

Constructive characterisations of the must -preorder for asynchrony

De Nicola and Hennessy's must -preorder is a liveness preserving refinement which states that a server q refines a server p if all clients satisfied by p are also satisfied by q . Owing to the universal quantification over clients, this definition does not yield a practical proof...

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

The adenylate cyclase toxin (CyaA) from Bordetella pertussis intoxicates host cells by directly translocating its N-terminal catalytic domain across the plasma membrane; however, the forces driving this unique process remain poorly defined. Here, we dissect the membrane transloca...

A ReSCAL-based numerical study on synergistic optimization of photovoltaic arrays for sand control and power generation

In arid desert environments, photovoltaic (PV) arrays not only serve as clean energy suppliers, but also act as physical barriers to mitigate wind-blown sand movement. Based on the Real-Space Cellular Automaton Laboratory (ReSCAL), this study explores the coupled effects of PV ar...

Itō and Itō-Wentzell chain rule for flows of conditional laws of continuous semimartingales: an easy approach

We provide a general Itō-Wentzell formula for a random field of maps on the Wasserstein space of probability measures, defined by continuous semimartingales, and evaluated along the flow of conditional distributions of another continuous semimartingale. Our method follows standar...

Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease

Abstract Background While pancreatic cysts have been described in syndromic ciliopathies, the pancreas is not commonly recognized as a target organ. However, several ciliary gene knockout mouse models develop a pancreatic phenotype combining acinar atrophy and adipocyte accumulat...

Intraarterial Thrombolysis: Past, Present, Future

Suboptimal clinical outcomes are common after ischemic stroke with large vessel occlusion despite current reperfusion treatment with intravenous thrombolysis and mechanical thrombectomy. Targeting residual distal arterial and microvascular occlusions with intraarterial thrombolys...

Evidence of a massive accretion event 1.8 billion years before the Gaia-Sausage-Enceladus merger

Abstract The merger history of the Galaxy has been traced back firmly to a redshift of 2 (10 billion years ago). While evidence for the existence of at least one more substantial merger before this time has been presented, its interpretation is yet to be fully established. Here w...

Autoantibodies neutralizing type I interferons underlie a third of cases of Chikungunya virus encephalitis or myelitis

Abstract Chikungunya virus (CHIKV) infection is typically not life-threatening but may, in rare cases, affect the central nervous system (CNS). In three cohorts of confirmed CHIKV cases from Martinique (French overseas territory) and Brazil (patients aged 0–89 years, n = 245), 20...

The limitations of non-mechanistic methods for characterizing pathogen-pathogen interactions: A simulation study

Abstract Pathogen-pathogen interactions occur when infection with one pathogen influences one’s chance of infection or disease due to another. Increasingly, evidence suggests that interactions are a common feature of infectious disease epidemiology. However, due to both the nonli...

Ryugu and Bennu preserve primordial isotopic heterogeneity absent from the meteorite record

Ivuna-type (CI) carbonaceous chondrites are commonly used as proxies for the composition of the planet-forming disk because their chemical abundances resemble those of the solar photosphere. However, their isotopic uniformity may reflect pervasive alteration and isotopic averagin...

Timing of antifibrotic therapy and prognosis in idiopathic pulmonary fibrosis: real-world evidence from the French Colibri-ILD SNDS database

According to the French 2022 National guideline, antifibrotic therapy should be initiated as soon as a diagnosis of idiopathic pulmonary fibrosis (IPF) is made, taking into account the individual assessment of the expected benefit and risks of treatment. However, in practice, tre...

GRB 260310A / SN 2026fgk: A Multi-Wavelength Study of a Nearby Underluminous Long GRB and SN with a Complex Afterglow

Abstract We present a comprehensive multi-wavelength study of GRB 260310A / SN 2026fgk, a nearby (z = 0.153), long-duration gamma-ray burst (GRB) with an exceptionally underluminous prompt γ-ray emission and a Comptonized spectrum. The burst occurred at the edge of a blue host ga...

Stellar Interpretation of Meteoritic Data and PLotting for Everyone (SIMPLE): Isotope Mixing Lines for Six Sets of Core-collapse Supernova Models

Abstract Bulk meteorites and their inclusions exhibit, for many chemical elements, isotopic variability produced by nucleosynthetic events in stars and supernovae before the formation of the Sun. While the exact astrophysical origins of these variations are still a matter of deba...

Trace Elements in Total Atmospheric Deposition Directly Measured Over the Caribbean Region: Natural Versus Anthropogenic Sources and Geographic Origin

Abstract Dust, sea salt, and anthropogenic and biogenic particles in total atmospheric deposition are sources of essential elements that can significantly impact biogeochemical cycles in the Atlantic Ocean and in islands of the Caribbean region. This unique 41‐month data set reco...

Iron Isotopes Reveal Fe Export Driven by Change of Tropical Weathering Regime

Abstract Unraveling paleoenvironmental signals recorded in laterites is crucial for quantifying weathering‐driven elemental fluxes at the Earth's surface. New stable iron isotope data (δ 56 Fe), combined with (U‐Th)/He ages in Fe‐oxides from a ferruginous duricrust from French Gu...

Constraints and opportunities: The case of the first French professional female rugby players

This study aims to address the lack of research on the dual-career experiences of the first generation of professional female rugby players in France. Specifically, it examines (1) the current status of professional female rugby players and (2) how they combine their rugby career...