Université Paris Cité

The Challenge of Meaningful Comparison: Assessing the Relation Between Social Comparison Orientation and Meaning in Life

Social comparison processes play a central role in social cognition, but their relation to meaning in life remains unclear. We conducted an integrative analysis of three online studies with American, Indian, Peruvian, and French participants. After harmonizing the study-specific...

Integrated transcriptomic and proteomic analysis reveals innate and adaptive immune dynamics in systemic autoinflammatory diseases

Systemic autoinflammatory diseases (SAIDs) are a diverse group of rare disorders with partially overlapping clinical features. However, their genetic makeup and treatment responses vary widely. Although inflammasome dysregulation is central to many SAIDs, recent studies suggest t...

LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial Infarction

Importance: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition is recommended as second- or third-line lipid-lowering therapy after myocardial infarction (MI), resulting in prolonged periods of inadequate low-density lipoprotein cholesterol (LDL-C) control. Whether...

FastCNV: fast and accurate copy number variation prediction from high-definition spatial transcriptomics and scRNA-seq data

Abstract Background Predicting DNA copy number variations (CNVs) from spatial transcriptomics (ST), including Visium HD, or single-cell RNA-sequencing (scRNA-seq) data helps to distinguish malignant from non-malignant cells and to characterize the clonal architecture of tumor cel...

Coupling of stable isotope probing and metagenomics reveals the diversity of viruses infecting formatotrophs during anaerobic digestion process

Abstract Background Viruses play a major role in regulating microbial community composition and activity, yet their diversity and host associations in anaerobic digestion (AD)—a complex biotechnological process converting organic waste into biogas—remain poorly characterized. Lin...

Establishing a Prognosis When Identifying Pathogenic Variants in Usher Syndrome/ DFNB ‐Related Genes: An Impossible Challenge?

As our results show that very few published variants could currently be considered causative of DFNB due to lack of precise clinical studies, strict and uniform criteria should be applied by authors publishing on USH/DFNB genes.

Death determination at the bedside: clinical judgement beyond criteria

In clinical practice, death determination—a core responsibility of critical care clinicians—is commonly taught as the technical application of standardized medical and legal criteria. However, contemporary practices, including resuscitation, death determination by neurological cr...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Venular-centered thrombo-inflammation drives microvascular failure after arterial recanalization in acute mesenteric ischemia

Abstract Background Acute mesenteric ischemia (AMI) remains associated with high mortality despite prompt revascularization, suggesting that downstream ischemia–reperfusion injury contributes to poor outcomes. However, the microvascular mechanisms underlying this process are not...

Lie structures in homotopy and isotopy calculi

Abstract We establish compatibility of Lie structures that appear in homotopy calculus of functors and isotopy calculus of embeddings. On one hand, we give a new proof of the Johnson–Arone–Mahowald result describing the layers of the Goodwillie tower of the identity functor, and...

Urbanisation and habitat loss favour thermophilic and monogynous ant species

Environmental changes such as urbanisation and related habitat loss and fragmentation profoundly impact ecological communities by altering habitats, resources, and microclimates. Yet, the impacts of the resulting environmental conditions on metacommunity dynamics, ranging from sp...

Global propagation of analyticity and unique continuation for semilinear waves

In this article, we develop a new method to prove both global propagation of analyticity and unique continuation in finite time for solutions of semilinear wave-type equations with analytic nonlinearity. It combines control theory techniques and Galerkin approximation, inspired b...

Delivery of multiple PspA fragments by CyaA toxoid induces broad protection against Streptococcus pneumoniae

Abstract Streptococcus pneumoniae is a leading cause of lower respiratory tract (LRT) infections and invasive pneumococcal diseases (IPD). Conjugate vaccines are effective against IPD and nasal colonization but offer coverage limited to serotypes included in the formulations. Pne...

Quantification of absolute IgG concentration in bat sera

Abstract Bats are endowed with a remarkable capacity to withstand important pathogens through evolutionary adaptations in their immune systems. Antibodies are essential component of the adaptive immune response and serve as a crucial biomarker, indicating both present and past pa...

Multi-analytical study of the effects of secondary working and recycling in Roman glass

The impact of secondary processing and recycling on the composition and redox equilibrium in archaeological glass remains difficult to assess. This paper reports the results of a multi-analytical study of glass finds from a Roman villa in southwestern France, revealing varying mi...

Post launch spectral and radiometric performances of MAJIS, the VIS-NIR imaging spectrometer of JUICE

Abstract. The post-launch spectral and radiometric performances of MAJIS, the VISNIR imaging spectrometer of the ESA Jupiter Icy Moon Explorer (JUICE), have been evaluated using observations performed during the Lunar-Earth Gravitational Assist (LEGA) of 19–20 August 2024 and obs...

Robot in a crib: How a playing robot helps us understand sensorimotor contingency learning

Learning sensorimotor contingencies—that is, the link between one’s actions and their sensory effects—is fundamental to developing body knowledge, understanding causality, and developing a sense of agency. In developmental psychology, this process is classically studied using the...

Longitudinal alignments and syntheses of multimodal clinical data for personalized medicine with the PULSE framework

Multimodal models capable of imputing diverse data used in single-cell biology studies provide potential foundational opportunities in clinical practice. However, patient data uniquely comprise longitudinal mosaic measurements that reflect underlying physiological dynamics and ex...

Differentiable Forward Modeling for Efficient and Accurate Shear Inference

Forthcoming Stage-IV dark energy optical surveys, such as LSST, have the ambitious goal of measuring cosmological parameters at sub-percent precision. Realizing their full scientific potential requires very precise measurement of the cosmic shear signal and control of correspondi...

Miscompartmentalization of microbiota-derived TMAO is a reversible driver in autism spectrum disorder

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder. Unlike genetics and gut dysbiosis, ASD appears to be homogeneous when considering tryptophan metabolism. Following these findings, we found that ASD was associated with the miscompartmentalization of t...