Université Paris Cité

Increased CSF PKR activation in Alzheimer’s disease is associated with APOE4 genotype

Abstract Objective Protein kinase R (PKR) is a stress-activated kinase implicated in translational control, neuroinflammation, and neurodegeneration. Although increased PKR activation was reported in Alzheimer’s disease (AD), prior studies relied on semi-quantitative methods. Thi...

Sublimation of Physical and Psychical Trauma in the Painting of Frida Kahlo

The painting work of Frida Kahlo is a diary and recounts events from the past (the marriage of her parents, the accident) and the present (her marriage with Diego Rivera, her miscarriage and the betrayal of Diego with her sister). Frida Kahlo takes her inspiration in the physical...

Phenolic Profiling and OECD-Guided Acute and Subacute Oral Toxicity Assessment of Cannabis sativa L. Seed Hydroethanolic Extract

Cannabis sativa L. seeds have been traditionally used in Moroccan folk medicine and are increasingly recognized as a valuable source of nutrients and bioactive phytochemicals with promising therapeutic properties. Despite their widespread traditional and nutritional use, scientif...

Simulation analysis of self-excited oscillating water jet with petal-shaped nozzle under confining pressure

The self-excited oscillating water jet is widely used in ocean engineering. Its effectiveness stems from the impact of cavitation collapse driven by periodic pressure pulsations. This study investigated the flow field evolution and vortex stretching mechanisms of self-excited osc...

A large-scale pipeline for LLM-assisted corpus annotation

Abstract As natural language corpora expand at an unprecedented rate, manual annotation remains a significant methodological bottleneck in corpus linguistic work. We address this challenge by presenting a scalable pipeline for automating grammatical annotation using large languag...

Extriangulated structures from stability conditions and application to braid representations

We use the notion of Bridgeland stability condition and an associated rank function to endow triangulated categories with extriangulated structures and study their extriangulated Grothendieck groups. This study is motivated by Khovanov–Seidel’s categorification of the Burau repre...

Reach and engagement in the ECAIL trial targeting socially disadvantaged families across the COVID-19 pandemic and cost-of-living crisis: A mixed-methods implementation study

Background The ECAIL trial, launched in 2017, was designed to evaluate a multicomponent intervention for childhood obesity prevention among hard-to-reach families. At a maternity hospital in Lille, France, healthcare providers screened pregnant women experiencing social vulnerabi...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

The human gut microbiome primes fever after vaccination

Fever is a common adverse reaction to vaccination, contributing to vaccine hesitancy and reduced uptake. To understand variation in fever risk, we longitudinally profiled fecal microbiota, oral temperature, and serological markers in 171 healthy adults receiving Severe acute resp...

Development and early implementation of a brief 2-day multidisciplinary parent training group for paediatric ARFID: A feasibility and acceptability study

OBJECTIVE: Many children with avoidant/restrictive food intake disorder (ARFID) cannot access appropriate care, as existing individual and family treatments are scarce, long and costly. We developed a brief 2-day (12-h) multidisciplinary parent training group and assessed its fea...

Super Bloom: Fast and Precise Filter for Streaming k -Mer Queries

Approximate membership query structures are used throughout sequence bioinformatics, from read screening and metagenomic classification to assembly, indexing, and error correction. Among them, Bloom filters remain the default choice. They are not the most efficient structures in...

Health utilities in individuals with alpha-1 antitrypsin deficiency with and without COPD from the EARCO registry

Background Data on health utilities in Alpha-1 antitrypsin deficiency (AATD) are scarce. This study aimed to evaluate health-related quality of life (HRQoL) using the EQ-5D in a cohort of AATD Pi*ZZ individuals from the European AATD Research Collaboration (EARCO) registry and to...

CGM-derived disposition index estimates beta cell function in individuals with islet autoimmunity who do not require insulin treatment; changes in the disposition index precede changes identified by CGM metrics 1 year later

Abstract Aims/hypothesis Monitoring of beta cell function in individuals with islet autoimmunity who do not require insulin treatment (preclinical type 1 diabetes) is normally done via OGTTs, posing major challenges given the invasiveness of the test. Here, we validated a disposi...

Neutralization titers reveal the structure of polyclonal antibody responses

The composition of a polyclonal antibody response is hard to measure experimentally but contains vital information about the robustness of immunity. Here, we argue that the statistics of neutralization titers alone can be used to make quantitative predictions about the compositio...

European joint programme HBM4EU - Bridging science and policy: experiences and lessons learned from the key partners in the scientific steering of the initiative

The European Joint Programme HBM4EU was established to address politically relevant questions on chemical risks to public health through a targeted human biomonitoring research programme. Running from 2017 to 2022, it was co-financed by the EU's Horizon 2020 Research and Innovati...

Mastodon: the command center for large-scale lineage-tracing microscopy datasets

Understanding development in living organisms requires following the divisions, movements, and fates of cells. While advances in microscopy have enabled whole-embryo imaging at the cellular level, extracting and analyzing cell lineages from these massive datasets remains a signif...

Escherichia coli ST131 isolates are rare in human meningitis but belong to a distinct O25b-fimH22 clade B lineage shared with avian pathogenic Escherichia coli

Escherichia coli ST131 is a globally disseminated extraintestinal lineage best known for its resistance-driven expansion, yet it is rarely reported as a cause of neonatal meningitis. Whether specific ST131 sublineages retain neuroinvasive potential remains poorly understood. We a...

Interobserver agreement in the diagnosis of endometrial atypical hyperplasia and the contribution of PTEN immunohistochemistry

Endometrial atypical hyperplasia (EAH) is a precancerous lesion whose distinction from non-atypical hyperplasia and endometrioid carcinoma carries major therapeutic implications, particularly in young women eligible for fertility-sparing treatment. Because diagnostic reproducibil...

Provenance and competence for CHIKV and DENV of Aedes albopictus populations

Aedes albopictus is one of the world’s most hazardous invasive species, increasingly implicated in the autochthonous transmission of Chikungunya (CHIKV) and Dengue (DENV) viruses in newly colonized areas. Since invading the Mediterranean Basin several in the early 1980s, recurren...

MOSAIC: Intra-tumoral heterogeneity characterization through large-scale spatial and cell-resolved multi-omics profiling

Understanding the tumor microenvironment has the potential to significantly advance precision oncology, but this effort has been hampered by the scarcity of consistent large data sets. Here, we introduce MOSAIC (Multi-Omics Spatial Atlas in Cancer), a multi-center clinical omics...