Université Paris Cité

Iron Isotopes Reveal Fe Export Driven by Change of Tropical Weathering Regime

Abstract Unraveling paleoenvironmental signals recorded in laterites is crucial for quantifying weathering‐driven elemental fluxes at the Earth's surface. New stable iron isotope data (δ 56 Fe), combined with (U‐Th)/He ages in Fe‐oxides from a ferruginous duricrust from French Gu...

Macrophage heterogeneity in human secondary lymphoid organs

Abstract Macrophages play a major role in immune responses and in the maintenance of tissue homeostasis. Most of our knowledge of macrophage biology comes from mouse studies, which have revealed the existence of distinct subpopulations differing in origin, life cycle and tissue-s...

Two Earliest Optical-UV Tidal Disruption Events Hidden in the SDSS DR7 Catalog Unveiled by the Transformer-based Spectrum Classifier

Abstract Optical spectroscopic features are decisive in the current identification of optical-UV tidal disruption events (TDEs). Regarding that the TDE estimated occurrence rate is 10 −5 –10 −4 galaxy −1 yr −1 by both theoretical and observational methods, large optical spectrosc...

Mechanism of Autophagic Extracellular Vesicles Revealed

Recent work by Mao and colleagues identifies a distinct class of small extracellular vesicles, termed autophagic extracellular vesicles (AEVs), generated from amphisomes upon autophagy induction. In this commentary, we discuss how this study provides important mechanistic insight...

Comparative performance of CMV IgM and IgG avidity assays for diagnosing a recent primary infection in the first trimester of pregnancy

First-trimester (T1) cytomegalovirus (CMV) screening relies on IgG, IgM, and IgG avidity testing, but assay performance may vary according to the infection timing. To evaluate the ability of two IgM and three IgG avidity assays to detect maternal primary CMV infection (MPI) occur...

Nuclear activities and interactome of the NS5 protein of tick-borne encephalitis virus

Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals, and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular pro...

Percentiles for crying, regurgitation, stool consistency, and CoMiSSTM in presumed healthy infants

Parents frequently consult health care professionals because of infant regurgitation, crying and stool consistency. The Cow’s Milk-related Symptom Score (CoMiSS TM ) is an awareness tool for cow’s milk allergy. We aimed to characterize the distribution of CoMiSS items in presumed...

Imaging in France: 2026 Update

France has seen significant advancements in radiology in recent years, driven by innovations in research and clinical practice. French groups have developed innovative imaging techniques and artificial intelligence applications in the field of diagnostic imaging and interventiona...

Frailty before disease onset: risk of mortality and chronic conditions in disease-free middle-aged adults

Abstract Frailty, defined by multisystem physiological decline and heightened vulnerability to stressors, is typically associated with aging and chronic disease. However, its relevance in apparently healthy individuals remains poorly understood. Identifying frailty in this popula...

Chance of live birth in women with recurrent pregnancy loss referred to a French assisted reproductive technology center

Recurrent pregnancy loss (RPL) is a multifactorial condition, with over 50% of cases remaining unexplained. The absence of therapeutic consensus raises questions regarding referral for assisted reproductive technology (ART). To evaluate live birth rates and predictors of success...

Molecular Rotors: From Newtonian Fluids to Functional Materials as Viscosity and Temperature Sensing Tools

ABSTRACT Molecular rotors (MRs) are a distinctive class of fluorescent molecules whose photophysical properties are influenced by their surrounding environment, making them valuable as viscosity nanosensors. However, interpreting their fluorescence responses in complex systems po...

Melt burst events in a dominantly amagmatic lithosphere at Gakkel Ridge in the Arctic Ocean

Abstract Alternation of magmatic and amagmatic seafloor along the slow and ultraslow spreading ridges is common. Yet, temporal variation is obscured by sediments blanketing oceanic basement away from spreading centers. Here we analyze aeromagnetic data covering zero age to ~35 Ma...

Diagnostic Accuracy of APTw and NOEw MRI Metrics for IDH Mutation and 1p/19q Codeletion Prediction in Gliomas

ABSTRACT Isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion are key molecular markers for glioma classification. Amide proton transfer weighted (APTw) and nuclear Overhauser effect–weighted (NOEw) markers showed promise for glioma characterization, by probing protein‐r...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...

Multicenter retrospective study on perceived effectiveness, reported side effects, and cognitive outcomes of SSRIs in 22q11.2 deletion syndrome

22q11.2 deletion syndrome (22q11DS) markedly increases risk of psychiatric disorders, including anxiety and mood disorders, and is associated with a spectrum of cognitive impairment, from borderline functioning to intellectual disability, with cognitive decline frequently reporte...

Visible mould and blood inflammatory phenotypes of asthma in adults: the CONSTANCES cohort

Studying the associations between indoor mould contamination and blood inflammatory phenotypes may provide further insight into the mechanisms by which this environmental factor affects asthma. Among 1870 adults with current asthma from a population-based cohort, 29.6% reported v...

Prediction error in low power intraocular lens in highly myopic eyes

To assess refractive prediction error (RPE) after cataract surgery in highly myopic eyes, focusing on the accuracy of intraocular lens (IOL) power calculations using the SRK/T formula without axial length adjustment. Tertiary ophthalmology department at Lariboisière Hospital, Par...

Reimbursement status, access delays and prices of orphan drugs in France: a population-stratified analysis of indications approved between 2021 and 2024

Abstract Background More and more treatments are available for patients with rare diseases. However, a marketing authorization (MA) for a new treatment does not mean access in France for all patients. Moreover, while rare diseases affect children mostly, paradoxically it seems th...

STABILOOP, a cohort trial to assess automated insulin delivery in the management of patients living with type 1 diabetes who are eligible for islet transplantation

A limited subset of people living with type 1 diabetes (T1D) is affected by extreme glycemic lability and frequent unpredictable severe hypoglycemia, significantly impairing quality of life and associated with higher morbidity, mortality, and healthcare costs. Islet transplantati...

Guidelines for Studying Mutagenesis in Quiescent Schizosaccharomyces pombe

All living organisms can enter a non-dividing state known as quiescence, which often functions as a survival strategy. In many cases, quiescent cells retain the ability to re-enter the cell cycle when conditions become favorable. Therefore, preserving the integrity of non-dividin...