Université Paris Cité

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Sterile Insect Technique in a n-patch System with Allee Effect and Mass Trapping: Modelling, Analysis and Simulations

Abstract The sterile insect technique (SIT) is a biological control method aimed at reducing or eliminating populations of pests and disease vectors. This technique involves releasing sterilised insects which, by mating with wild individuals, will reduce the target population. In...

Synergism Between Krameria lappacea (Dombey) Burdet & B.B.Simpson Extracts and Gentamicin Against Gram-Positive Bacteria

Background: Combination therapy is increasingly explored as an alternative approach to manage bacterial infections and limit the emergence of antibiotic resistance. Building on traditional medicinal knowledge, this study aimed to investigate the potential synergistic antibacteria...

Mechanical Thrombectomy Versus Medical Management for Large Ischemic Core Stroke Identified before Inter‐Hospital Transfer: A Post Hoc Analysis of the LASTE Trial

Objective This study assessed the efficacy of thrombectomy in acute ischemic stroke because of large‐vessel occlusion (AIS‐LVO) initially admitted to primary stroke centers (PSC) and subsequently transferred to a comprehensive stroke center (CSC), with a large ischemic core ident...

Characteristic cycle and wild Lefschetz theorems

Abstract By relying on a new approach to Lefschetz type questions based on Beilinson’s singular support and Saito’s characteristic cycle, we prove an instance of the wild Lefschetz theorem envisioned by Deligne. Our main tool are new finiteness results for the characteristic cycl...

Atenolol or Bisoprolol after Myocardial Infarction without Recorded Heart Failure

BACKGROUND: Beta-blockers are a cornerstone of therapy following myocardial infarction. The effect of different β-blockers on the outcomes of patients without heart failure after myocardial infarction is not well-studied. METHODS: This observational cohort study used administrati...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

WHOLE-GENOME SEQUENCING AS A FIRST-TIER TEST FOR SCHIZOPHRENIA AND BIPOLAR DISORDER: THE FRENCH CLINICAL IMPLEMENTATION

The integration of genomic medicine into healthcare systems represents a major translational challenge. In France, the Plan France Médecine Génomique 2025 (PFMG2025) was designed to directly embed whole-genome sequencing (WGS) into routine clinical care through a nationwide infra...

Overcoming Sampling Limitations Using Machine-Learned Interatomic Potentials: The Case of Water-in-Salt Electrolytes

Abstract Machine-learned interatomic potentials hold the promise to enable the modeling of highly concentrated liquids over meaningful time scales, far from reach for current ab initio electronic structure methods. Here we evaluate the performances of various MACE potentials in m...

Underground Signals: The Ecological Power of Root Volatiles

Root volatiles mediate diverse belowground interactions among plants, microbes, and invertebrates, but biological and environmental conditions strongly influence their production, movement, perception, and ecological effects. This review synthesizes current knowledge through an i...

What can we learn on ALS pathophysiology from iPSC-derived motor neurons harbouring TARBDP mutations: a systematic review

The degenerating motor neurons of amyotrophic lateral sclerosis (ALS) patients are characterized by the accumulation of cytoplasmic aggregates, specifically enriched in ubiquitinated TDP-43. Expressed mainly in the nucleus and partially in the cytoplasm to execute its role in RNA...

Lifetime exposure to atypical working hours among healthcare professionals compared with the workforce in other sectors: Nationwide cohort study

Background Despite well-documented health risks, cumulative exposure to atypical working hours (AWH) over a career remains poorly quantified, especially among healthcare workers. Objectives This study aimed to compare career-long AWH exposure among healthcare professionals and ot...

Anti-thymocyte globulin triggers TNF-dependent cell death in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) accounts for one of the most aggressive hematological tumors associated with poor prognosis, notably for relapsed and refractory patients. Hence, an unmet medical need persists for T-ALL patients who fail to durably respond to conventio...

Low intensity transcranial electrical stimulation for schizophrenia: a triple-blind, randomized, sham-controlled multicenter trial (STIM’Zo)

Persistent symptoms in schizophrenia remain a major therapeutic challenge. Noninvasive electrical stimulation such as transcranial random noise stimulation (tRNS) may alleviate auditory hallucinations and negative symptoms, although existing evidence is limited to case reports an...

The Cloud Feedback Model Intercomparison Project (CFMIP) contribution to CMIP7

Cloud processes constitute one of the key uncertainties for climate change projections. The fourth iteration of the Cloud Feedback Model Intercomparison Project, CFMIP4, contributes to the Coupled Model Intercomparison Project phase 7 (CMIP7), by providing a set of global climate...

Not speaking my language: playback experiments reveal early-orphaned human-reared adult cheetahs lack interest in species-specific vocalizations

Abstract Early adult models, particularly the mother, play an essential role in tuning perception to build the multimodal representation of species-specific social signals, especially in mammals. Therefore, early maternal loss adversely impacts social integration in mammals. More...

Paler within the city: Carotenoid‐based colouration covaries negatively with the proportion of impervious surface in great tit ( Parus major ) territories across Europe

Urbanisation alters resource availability and exposes wildlife to novel environmental stressors, potentially driving phenotypic divergence. Carotenoid-based plumage colouration is a condition-dependent trait linked to dietary carotenoid acquisition and physiological allocation tr...

Extending the ATP9A ‐Related Phenotypic Spectrum: Indication of Schizophrenia Susceptibility

ABSTRACT ATP9A, which belongs to the P4‐ATPase family of proteins, is involved in the efficient transport of vesicles from the Golgi apparatus to the plasma membrane, as well as the release of extracellular vesicles from human cells. In 2021, a loss‐of‐function variant of this ge...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

Differentiable latent structure discovery for interpretable forecasting in clinical time series

Abstract Background Timely, uncertainty-aware forecasting from irregular electronic health records (EHR) can support critical-care decisions, yet most approaches either impute to a grid or sacrifice interpretability. We introduce StructGP, a continuous-time multi-task Gaussian pr...