The University of Tokyo

Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress

Cancer cells maintain chronically elevated levels of reactive oxygen species (ROS) while relying on robust antioxidant programs to preserve redox homeostasis and viability. Although therapeutic strategies that disrupt this balance to induce lethal oxidative stress and ferroptosis...

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage–fibroblast interactions to attenuate pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibr...

Development of a two-step cross-cultivar grape quality prediction model using outdoor hyperspectral imaging in three grape cultivars: Rondo, Zweigelt, and Kerner

Sensing technologies that are independent of berry-color variation across grape cultivars, particularly under varying environmental stress conditions, are crucial for advancing precision viticulture. This study developed a two-step cross-cultivar quality prediction model for thre...

Hall Shift Current and Nonlinear Anomalous Hall Effect in Gapped Dirac Fermion Systems

We discuss a new mechanism for the nonlinear anomalous Hall effect in tilted two-dimensional gapped Dirac fermion systems. This mechanism originates from a side-jump displacement associated with Landau–Zener tunneling across the mass gap. In lightly doped tilted Dirac systems wit...