The University of Tokyo

Fluvial geomorphological development associated with MIS 5e–4 sea-level fluctuations in the lower reaches of the Kinu River, Japan

Understanding fluvial geomorphological responses to sea-level fluctuations during Marine Isotope Stage (MIS) 5 is essential for predicting future evolution of coastal lowlands under sustained high sea-level conditions. Although downstream river development since the Last Glacial...

Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry

BACKGROUND: Cardiac sarcoidosis (CS) may lead to serious outcomes, but large-scale data are lacking because of its rarity, diagnostic uncertainty, and heterogeneous clinical presentations. Actual management and outcomes, including recurrence, are not well understood. This study a...

On the Generalized Conditional Gradient Method for Mean Field Games with Local Coupling Terms

Abstract We study the generalized conditional gradient (GCG) method for time-dependent second-order mean field games (MFG) with local coupling terms. While explicit convergence rates of the GCG method were previously established only for globally coupled interactions, the assumpt...

Programming sequential deployment of origami via kinematic transition fronts

Propagating transition fronts, in which local interactions sequentially trigger state changes, are widely observed across natural, biological, and engineered systems. While such propagation has been engineered using energy-driven instabilities, front propagation governed purely b...

Cohesin prevents local mixing of condensed euchromatic domains in living human cells

The human genome is folded into chromatin loops by the cohesin complex, forming functional chromatin domains that underlie transcription and DNA replication/repair. However, how cohesin organizes these domains in living cells, especially in active euchromatin, remains elusive. To...

Distortion Induced by Planarization in Urban Road Networks: An Empirical Assessment Using Edge-Betweenness-Prioritized Sub-graphs Across 40 Cities

Urban road networks are routinely represented as planar graphs even though overpasses, underpasses, and multi-level interchanges create crossings that no planar embedding can preserve. This study quantifies the distortion introduced by this representational choice across 40 citie...

Life Cycle Assessment of Automobile Parts Made of Cellulose Nanofiber-Reinforced Bio-Polyethylene Using the Pulp Direct Kneading Method

The development of cellulose nanofiber-reinforced plastics (CNFRPs) is a possible option for reducing the environmental impact of plastic products, such as automotive components. This study conducted a life cycle assessment (LCA) of CNF-reinforced bio-polyethylene (CNF-BioPE) as...

Age and sex estimation from Japanese femoral computed tomographic images using foundation models

OBJECTIVE: This study evaluated the feasibility and performance of a deep learning-based multitask framework for estimating sex and age using femoral CT images in a Japanese population. MATERIALS AND METHODS: Postmortem CT (PMCT) data from 1,489 Japanese individuals (1,003 males,...

Pressure-Induced Interplay between Heavy-Fermion and Mn-Derived Magnetic States in CeMnSi

We investigated pressure effects on the nontrivial heavy-fermion antiferromagnet CeMnSi by means of electrical resistivity (ρ) and powder X-ray diffraction. With increasing pressure, the antiferromagnetic order of Mn (T N ∼ 240 K at ambient pressure) is rapidly suppressed and dis...

Conditioned stochastic stability of equilibrium states on uniformly expanding repellers

Abstract We propose a notion of conditioned stochastic stability of invariant measures on repellers: we consider whether quasi-ergodic measures of absorbing Markov processes, generated by random perturbations of the deterministic dynamics and conditioned upon survival in a neighb...

Determination of the relative stereochemistry of flexible ring systems by a cage-based crystalline sponge method

Abstract We present a cage-based crystalline sponge method as a practical strategy for the relative stereochemical determination of flexible saturated heterocycles that are not amenable to nuclear magnetic resonance analysis. Validated using a bis-tetrahydrofuran series and compl...

AIS-Based Forecasting of STEAM-Estimated Ship CO2 Emissions for Sustainable Maritime Transportation Using a Spatio-Temporal Graph Transformer

Accurate short-horizon forecasting of ship CO2 emissions is important for maritime carbon monitoring, operational assessment, and the transition toward sustainable maritime transportation. However, reliable forecasting remains challenging because ship emissions are affected by te...

Effect of oxygen ion irradiation on the visible, infrared, and Raman spectra of Phobos candidate materials: implications on the space weathering by Martian atmosphere-derived ions

Abstract The origin of Martian satellites is still under debate. Nevertheless, such information could give insights into the evolution of the Martian system and planetary formation processes. To address these questions, MMX (Martian Moons eXploration) will conduct spectroscopy (v...

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and...

Structure-oriented deep learning for semantic segmentation of bridge point clouds

Bridges built during the post-war construction boom are reaching the end of their design life, and their inspection still relies mainly on manual visual assessment. The specific question addressed is whether bridge components can be segmented accurately and efficiently from raw p...

Required simulated population ratios for valid assessment of shared autonomous vehicles’ impact using agent-based models

The impact of shared autonomous vehicles (SAV) on people’s lives, cities, and transportation has been actively discussed in recent years, as the technology is expected to become widespread in the future. Agent-based simulation analysis continues to develop as a method for explori...

Aging beyond older adults: Transdisciplinary perspectives on demographic change in Japan

Population aging is increasingly recognized not merely as a demographic phenomenon, but as a broader societal transformation reshaping care systems, labor structures, infrastructure, communication, governance, and everyday social relations. Using Japan as an example of an advance...

Instability-Driven Torsion Sign Flips Revealed by the Laplacian Structure of Curvature Support Fields in Protein Backbones

Abstract Torsion sign flips are fundamental discrete events in protein backbone dynamics, yet their geometric triggers remain poorly understood. While traditionally associated with singular critical points, we show that these transitions are primarily driven by local geometric in...

Staggered Quadruple-Rutile Oxides as Low-Strain and High-Power Anodes for Lithium-Ion Batteries

Abstract Tunnel-structured oxides provide attractive hosts for lithium-ion storage. However, their application is frequently limited by structural instability or sluggish ion transport at high lithium contents. Here, we demonstrate that the staggered quadruple-rutile framework re...

A divergent betacoronavirus with a functional furin cleavage site in South American bats

Abstract Bats are natural reservoirs for a wide range of RNA viruses. Members of the genus Betacoronavirus , including Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) and Middle East Respiratory Syndrome virus (MERS-CoV), have attracted particular attention due to their re...