The University of Tokyo

Strong connections of locally clustered neurons in the upper-layer cortex underlie schizophrenia-related auditory deviance detection

The detection of unexpected sounds, or auditory deviance detection, is thought to be achieved by comparing prediction signals and sensory inputs in the auditory cortex. This process is markedly impaired in patients with schizophrenia. However, the local circuit properties underly...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

Cryo-EM structure of the bicarbonate receptor GPR30

G-protein-coupled receptor 30 (GPR30) is a bicarbonate receptor that plays a vital role in cellular responses to extracellular pH and ion homeostasis. Despite its significance, the mechanisms by which GPR30 interacts with bicarbonate ions remain elusive. There is no consensus on...

DESI Strong Lens Foundry. IV. Spectroscopic Confirmation of DESI Lens Candidates with VLT/MUSE

Abstract We present integral field spectroscopic observations of 76 strong gravitational lens candidates identified with a residual neural network in the DESI Legacy Imaging Surveys, obtained with the Multi Unit Spectroscopic Explorer (MUSE) on ESO’s Very Large Telescope. These o...

Asymptotics of lowlying Dirichlet eigenvalues of Witten Laplacians on domains in pinned path groups

Abstract Let G be a compact connected Lie group and P e , a ( G ) = C ([0, 1] → G | γ (0) = e , γ (1) = a ) be the pinned path space with a pinned Brownian motion measure ν λ , a defined by the heat kernel p ( λ −1 t , x , y ), where λ is a positive parameter. We consider a Witte...

Low InterfacialContact Resistance between Carbon-BasedGas Diffusion Layer and Sputter-Deposited Anatase TiO2

Abstract Reducing the interfacial contact resistance between separators and gas diffusion layers is critical for achieving high-power polymer-electrolyte membrane fuel cells. Stringent targets for contact resistance below 3.0 mΩ cm2 have been proposed; however, achieving such val...

Measuring Ocean Surface Waves

Abstract Propagating waves on the ocean surface can be represented as a stochastic process whose statistics are characterized by a spectrum. This paper reviews methods for measuring the wave spectrum and related quantities. Observations begin by sensing fluid dynamical properties...

Cryo-EM structure of pro-aggregant P301L/S320F double-mutant tau filaments formed in mouse brains following peripheral AAV delivery

Abstract Tauopathies are characterized by the accumulation of abnormally phosphorylated tau filaments, with disease-specific folds revealed by cryo-electron microscopy (cryo-EM). Here, we delivered a recombinant human tau carrying the P301L/S320F double mutation into App NL-G-F /...

Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress

LRRK2, the Parkinson's disease-associated kinase, phosphorylates a subset of Rab GTPases and regulates membrane dynamics. We previously reported that lysosomal stress activates LRRK2 and thereby induces the exocytic secretion of lysosomal contents, but the detailed secretion mech...

Photoinduced Switching-onof Intermolecular FerromagneticExchange in a Cobalt–Viologen Donor–Acceptor Assembly

Abstract Crystal engineering of anisotropic molecular solids that translate photoinduced charge transfer into switchable magnetic exchange offers a route to optically addressable exchange-correlated magnetic states. Here, we show that (MV)[Co(pdms)2](MeOH)2(MeCN), a donor–accepto...

Precision Greenhouse Rose Phenotyping from UAV Imagery Using a Multi-Source Dataset and Lightweight BloomRoseNet

Accurate detection of blooming roses and flower buds is essential for greenhouse phenotyping, cultivation scheduling, harvest planning, and yield management. However, UAV-derived greenhouse imagery presents major challenges because rose targets are often small, densely distribute...

HydrateMorphological Evolution and Its Relation withHigh Permeability Characteristics in Hydrate-Bearing Sediments

Abstract Permeability is a key parameter that reflects the flow capacity of the hydrate-bearing sediments. Permeability decreases with increasing hydrate saturation (Sh), as predicted by conventional permeability reduction models. Our previous research proposed that hydrate-beari...

Development of Ultrasmall Manganese Oxides for Multi-Functional Applications

Abstract Manganese oxides have attracted considerable attention as sustainable functional materials owing to their earth abundance, rich redox chemistry, and structural diversity. Particle-size engineering has emerged as an effective strategy for enhancing their electrochemical a...

Architectural Design and Operational Method of a House by Mode-Changing for Environmental Adjustment: A Case Study

Background: Many studies have been carried out using scientific approaches, but the targets are uncertain due to variable environmental and human factors. Therefore, these two factors need to be integrated into modes, which represent combinations of devices in specific statuses....

A ComplexSpin-Transition Thermal Hysteresis Unlockedby Two Competing Symmetry-Breakings

Abstract The spin-crossover material [Fe(NH2trz)3](NO3)2 belongs to the class of 1D triazole-based polymeric SCO complexes. It exhibits a thermal phase transition, with a 28 K wide thermal hysteresis, characterized by phase transition temperatures T↑ = 346 K upon warming and T↓ =...

Recent advances in flexible near infrared—short wave infrared image sensors: from materials to applications

Near-infrared and short-wave infrared (NIR–SWIR) light reveals molecular signatures and penetrates scattering media, advantages that are greatest in direct contact with target. Rigid, conventional imagers cannot meet this requirement. Flexible imagers, by contrast, conform to ski...

A multidimensional analysis of CGM-derived glucose metrics in type 1 diabetes: differential associations of insulin degludec and insulin glargine U300

Ultra-long-acting basal insulins, insulin degludec (IDeg) and insulin glargine U300 (IGlarU300), are widely used in type 1 diabetes mellitus (T1DM), but their differential effects on multidimensional continuous glucose monitoring (CGM) profiles remain unclear. We aimed to identif...

Emotional responses and perceptions of false alarms in flood warnings and their impact on evacuation action: an empirical analysis of the Kyushu Region, Japan

Abstract Repeated false alarms for adverse weather events may reduce people’s willingness to take appropriate actions, such as evacuation. Therefore, understanding how false alarms influence perceptions and actions is essential for building effective early warning systems (EWS)....

Wide-field magnetic imaging of shielding-current-driven vortex rearrangement under local heating using diamond quantum sensors

Understanding and controlling vortex motion in superconductors are important both for suppressing dissipation in superconducting devices and for device applications that exploit vortices. In this work, we quantitatively imaged the stray magnetic field distribution of vortices in...

Jump into New Fields : How to Cultivate the Originality of a Researcher

This article reflects on the author's research career and thoughts, emphasizing the importance of crossing disciplinary boundaries to cultivate originality as a scientist. Drawing on experiences in surface and interface science, thin films, electrochemistry, solid-state ionics, a...