The University of Tokyo

Construction of signed distance functions through an elliptic equation

Motivated by recent advances in structural optimization, we propose a novel method for constructing the distance function to the boundary of a given domain. Building on and extending the celebrated Varadhan asymptotic theory, our approach reformulates the governing equation into...

Selective Decarbonylative Bromination of Aromatic Aldehydes Enabled by Ensemble-Engineered Au–Pd Alloy Nanoparticle Catalysts

Abstract Bromoarenes are important structural motifs across a wide range of chemical fields and serve as versatile synthetic intermediates. However, the direct synthesis of bromoarenes from ubiquitous and readily available aldehydes has remained challenging. Herein, we report the...

Healthcare burden and clinical spectrum of symptomatic polycystic liver disease in Japan: a nationwide epidemiological survey

Abstract Background Polycystic liver disease (PLD) is often asymptomatic, but some patients develop symptoms or complications requiring care or intervention. The nationwide burden of symptomatic PLD remains poorly defined. We conducted a nationwide survey to estimate the number a...

Enabling climate action: A nexus approach for delivering co-benefits across biodiversity, water, food, and health

Climate response options rarely affect biodiversity, water, food, and health in uniform ways. This comparative analysis examines why technically viable response options generate uneven cross-nexus outcomes, and how governance and justice conditions shape whether these outcomes be...

Tsunami forerunner of the 2024 Noto Peninsula earthquake observed near the mouth of the Kurobe River, Japan

Abstract The 2024 Noto Peninsula earthquake occurred along the northern coast of the Noto Peninsula in Japan and generated a large tsunami. The earthquake also caused submarine landslides that generated local tsunamis in Toyama Bay. When large earthquakes occurred near the coast,...

Are X-Ray Atmospheres Heated by Turbulent Dissipation? XRISM Constraints

Abstract We evaluate whether dissipation of turbulence injected into hot cluster atmospheres by jets and bubbles can offset radiative cooling flows. No trends are found between atmospheric velocity dispersion, σ v , and either the ratio of kinetic to thermal energy or jet power o...

Causality-integrated graph learning for multi-endpoint toxicity prediction

Toxicity prediction remains a longstanding challenge in the safety assessment of numerous artificial chemicals. While conventional single-endpoint models are effective for predicting many molecular properties, they fail to capture the complex mechanisms underlying toxicity, which...

Cardiovascular complications in adults with clinically diagnosed osteogenesis imperfecta: A cross-sectional study with echocardiography and magnetic resonance imaging

Background: Osteogenesis imperfecta (OI) is a congenital bone fragility disorder, in which 90% of patients have abnormalities in type 1 collagen. Cardiovascular complications, including valvular heart disease and vascular aneurysms, are reportedly comorbid with this disease. Meth...

Heterogeneous effects of bottom-up responsiveness and top-down central environmental inspection on corporate green innovation across ownership and competition

This paper examines how bottom-up municipal responsiveness and top-down central environmental inspection pressure shape firms' green innovation behavior in China. Using a firm-level panel of all non-financial A-listed firms, patent data from the China Research Data Services Platf...

Noncatalytic Synthesis of High‐Density and Small‐Diameter WS 2 Nanotubes

ABSTRACT A substrate‐engineered, noncatalytic strategy is developed for the controlled synthesis of high‐density WS 2 nanotubes by decoupling nanowire precursor growth from vapor‐phase sulfuration. The process enables precise structural control and yields dense nanotube networks...

Peak ground acceleration underestimates narrow-band seismic amplification on mountain slopes

Abstract Topographic amplification is widely invoked to explain strong shaking and slope failure in mountainous terrain, yet direct field observations remain limited. Here we analyze 24 regional earthquakes recorded by a four-station strong-motion array spanning a ridge crest, a...

Observation of orbital-angular-momentum-driven temperature modulation via the spin Peltier effect

Angular-momentum transport provides a pathway for controlling energy flow in solids beyond conventional charge-based mechanisms. Although spin currents are known to mediate spin-caloritronic phenomena such as the spin Peltier effect (SPE), the role of orbital angular momentum (OA...

Indication of stochastic photothermal dynamics around a topological defect in a chiral magnet

Chiral magnets host topologically protected spin textures whose nonequilibrium dynamics are crucial in phase transitions and domain evolution, yet ultrafast defect-mediated processes remain poorly understood. Here, we investigate a photothermally induced helical-to-paramagnetic p...

CAM: A Causality-Based Analysis Framework for Multi-agent Code Generation Systems

Despite the remarkable success that Multi-Agent Code Generation Systems (MACGS) have achieved, the inherent complexity of multi-agent architectures produces substantial volumes of intermediate outputs. To date, the individual importance of these intermediate outputs to the system...

Randomized Subspace Gradient Method for Constrained Optimization

We propose randomized subspace gradient methods for high-dimensional constrained optimization. Whereas there are related studies on unconstrained optimization problems, there are relatively few for constrained optimization problems because of the difficulty of handling constraint...

Code-MUE: Measuring Code LLMs’ Uncertainty through Execution-Based Semantic Interaction Graphs

As Code Large Language Models (LLMs) become central to modern software engineering, their inherent stochasticity poses significant real-world risks, where even minor errors can lead to severe functional, security, or safety consequences. Reliable automation, therefore, demands th...

Antitumor effects of CEP32496 on urothelial carcinoma with BRAF mutation (V595E) in dogs.

< 0.05) in tumor growth in mice, with severe and extensive necrosis on histopathological examination. These results suggested that CEP32496 exerts antitumor effects on both cell proliferation and tumor growth in UC with V595E.

The WoKaS-Iso database: workflow for a global compilation of oxygen-18 and deuterium records in karst springs and cave drip water for enhanced understanding of karst systems

For analysing karst hydrogeological systems, observations of karst springs and cave drips are considered indispensable. In addition to hydrometric observations, knowing the oxygen and hydrogen stable isotope ratios has improved the understanding of vadose zone and aquifer dynamic...

Fast Bosonic Control via Multiphoton Qubit-Oscillator Interactions

We study the problem of n -fold rotationally symmetric bosonic state preparation, which is of great importance to bosonic quantum error correction, using a multiphoton interaction between an oscillator and an auxiliary qubit. We present an n -photon Law-Eberly ( n LE) protocol th...

Sequentially Self-Assembled Supramolecular Nanocomplexes Enable Systemic Cas9 RNP Delivery and In Vivo Tumor Genome Editing

In vivo genome editing utilizing Cas9/sgRNA ribonucleoproteins (RNPs) holds substantial therapeutic promise, yet rapid bloodstream clearance and degradation of RNPs have hindered its accumulation within the target site and effective gene editing. Herein, we report a supramolecula...