The University of Sydney

Extended dispensing intervals for pancreatic enzyme extract without access destabilisation: a national retrospective study evaluating supply resilience during policy changes and medicine shortages in Australia

Objective This study aims to describe national trends in pancreatic enzyme replacement therapy (PERT) dispensing in Australia and assess changes following the introduction of 60-day prescription dispensing, in the context of medicine shortages and market changes. Methods Publicly...

Factors Associated with Extreme Waiting Times for Child Developmental Diagnostic Assessments: A Mixed-Methods Service Evaluation in Sydney

Background: Previous Australian child developmental assessment service (CDAS) cohorts have identified a small proportion of children experiencing extreme waiting times (≥730 days) for standardised developmental assessments. However, factors associated with these extreme waits rem...

End-of-life planning and its governing policies: a comparison of New South Wales public health facility documents

OBJECTIVE: This desktop/scoping document review aimed to determine differences in availability, content, definitions, and terminology used in NSW Health policy documents that pertained to end-of-life planning. METHODS: A desktop/scoping comparative analysis of identified document...

Following the rules: which type 1 diabetes guidelines, protocols and recommendations are tertiary clinics in Australia following? A quantitative study

OBJECTIVES: This study characterises the use of type 1 diabetes (T1D) guidelines and protocols in Australian T1D clinics working with paediatric patients, and determines if management practices align with T1D-specific guidelines. METHODS: T1D clinic service leaders responded to a...

A multi-centre study of belatacept and sirolimus for islet transplantation

Abstract Aims/hypothesis Islet transplantation is an appropriate treatment for selected individuals with type 1 diabetes mellitus and hypoglycaemia unawareness. The gold standard of maintenance immunosuppression to prevent allograft rejection is calcineurin inhibitor-based therap...

Model 1b analytical performance specifications – report on the Prague 2025 workshop

diagnostic medical devices (IVD MD) meet regulatory and quality standards before market release; for external quality assurance assessments; for quality control, monitoring reagent lot-to-lot variability, and allowing preanalytical variation assessments in labs; and for guiding p...

Can artificial intelligence improve precision dosing? a systematic review of narrow therapeutic index drugs

Abstract Background Precision dosing of narrow therapeutic index drugs remains challenging because of substantial interindividual variability and the narrow margin between therapeutic efficacy and toxicity. Artificial intelligence (AI)–based approaches may improve individualized...

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

Peptide binders provide a versatile modality for modulating protein targets that are poorly addressed by small molecules, but their discovery is constrained by sample-intensive screening or reliance on structural templates. Sequence-first generation offers a scalable alternative...

Physical activity from bus travel: objective estimates linking accelerometer and travel card data

Background Low physical activity contributes to chronic disease and premature death. Public transport can integrate activity into daily routines, but robust methods are needed to estimate physical activity during public transport trips. This study quantified duration, intensity,...

Hyperbolic confinement: self-assembly of asymmetric diblock co-polymers on triply periodic minimal surfaces

Abstract We investigate the self-assembly of compositionally asymmetric AB diblock co-polymers confined to thin hyperbolic films on the three cubic minimal surfaces: the primitive, the diamond and the gyroid. To analyse and quantify the assemblies, we use a computational pipeline...

Effects of a neuromuscular warm-up on Y-balance, countermovement jump performance, and stroke velocity in adolescent table tennis players

Background/Objective Adolescent table tennis players are exposed to substantial physical and psychological demands during a period of ongoing growth and development, placing high demands on movement control, explosive performance, and sport-specific stroke execution. This study i...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

Steric stabilizers inhibit or enhance enzymatic digestion depending on the internal nanostructure of lipid nanoparticles

Abstract Lipidic nanoparticles (LNPs), including liposomes and cubosomes, are widely employed drug delivery systems owing to their biocompatibility and capacity for stimuli-responsive ‘smart’ drug release. Steric stabilizers, including DSPE-PEG-2000 and Pluronic F127, are commonl...

Upward single-nozzle sprays: Droplet count, size, and velocity under flash pressures with directional conditional filtering

This study investigates the influence of pressure variation on droplet characteristics (count, size) and dynamics (velocity) in upward atomised full-cone sprays. The challenges of understanding the fundamental droplet behaviour in spray-flash desalination systems further imposes...

Effect of Testosterone Treatment on Leucocyte Telomere Length in Men: Results From a Randomised Placebo‐Controlled Trial

BACKGROUND: Lower testosterone concentrations in older men are associated with poorer health outcomes. OBJECTIVE: We examined whether, on a background of lifestyle intervention, testosterone treatment modulates leucocyte telomere length, a postulated marker of biological ageing,...

Seeing Inequalities: Self-Reported Visual Difficulty and Eye Care Utilization Among Women in Malawi, a Secondary Analysis of the 2024 Demographic and Health Survey Data

Background: This study aimed to identify the factors associated with self-reported visual difficulty and uptake of spectacle/contact lens correction among women of reproductive age in Malawi. Methods: We conducted a cross-sectional secondary analysis of the 2024 Malawi Demographi...

Prenatal Genomics for Sonographers: Enhancing Confidence, Communication, and Clinical Care

ABSTRACT Genomic medicine is advancing rapidly, bringing significant changes to prenatal care and expanding the role of health professionals. As clinicians responsible for performing prenatal ultrasounds which may detect fetal anomalies and ultimately lead to genetic diagnoses, s...

The impact of fuel prices and supply availability on user behavioural change in Australian household travel amidst global turmoil

The global conflict in the Middle East is having a significant impact on the availability of oil to many countries, with Australia feeling the impact more than most countries. Fuel prices escalated during the first three weeks of the war (up to the end of March 2026), typically b...

Dissolved organic matter composition and mineral surface chemistry modulate organic retention and formation of mineral associated organic matter

The interaction between dissolved organic matter (DOM) and minerals governs OM stabilisation in soils. Heterogeneous composition of DOM and diverse mineral surface characteristics in soils make it challenging to determine reaction mechanisms at mineral-organic interfaces. To dete...

Maximising the ‘co’ in co-design through facilitator actions: co-designers’ perspectives on what makes their participation in co-design meaningful

Co-design is a participatory approach to service development and research that is increasingly expected within the mental health sector. It involves end users being involved throughout a design process, not simply by providing opinions, but through shared decision making. Evidenc...