Sichuan University

Overcoming Biological Barriers with Sononanomedicine: New Horizons in Oncology and Neurology

Abstract Biological barriers, including the tumor microenvironment and the blood–brain barrier, represent the primary bottleneck for the clinical translation of nanomedicines in oncology and neurology. Ultrasound, characterized by noninvasiveness, deep tissue penetration, and hig...

Ultrasound‐guided long peripheral catheter placement in adults with difficult intravenous access in the emergency department

Abstract Background Reliable vascular access is difficult to establish in patients with difficult intravenous access (DIVA) in the emergency department (ED). Long peripheral catheters (LPCs) offer durable peripheral access in selected patients. The feasibility, safety, and effect...

Comparative evaluation of dental pulp and periodontal ligament stem cell sheets for rescuing periodontal-like tissue formation in cryopreserved tooth autotransplantation

Autologous tooth transplantation (ATT) is a biologically based approach for the management of tooth loss, particularly among adolescents. However, its broader application is limited by challenges associated with tooth cryopreservation and stem cell-based strategies, and current s...

Emergency surgical management of acute Stanford type A aortic dissection in a primigravida at 29 weeks gestation

Rationale: Acute aortic dissection during the 3rd trimester of pregnancy is a catastrophic cardiovascular emergency. The management is complex, requiring a multidisciplinary strategy to balance the competing risks of aortic rupture and fetal prematurity, as well as the conflict b...

Flood-driven hydraulic-habitat indicators reveal geomorphic associations and functional complementarity across Contrasting River morphologies

Riverine topographic diversity is widely associated with spatial and temporal variation in hydraulic habitat under flood disturbance. Yet, most existing habitat assessments remain limited to static or quasi-steady flow conditions, restricting the development of indicators that ca...

Effects of combined admixtures on properties of ultrafine cement grouting materials and fitting characterization of water absorption

Due to their larger particle size, traditional ordinary silicate grouting materials cannot be effectively injected into the cracks of tunnel rock, resulting in suboptimal grouting performance. In this study, orthogonal experiments were conducted to systematically investigate the...

Causal relationship between metabolites, cerebral volume, and amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor neuron degeneration. Although metabolic abnormalities have been implicated in ALS, the causal relationships between circulating metabolites and ALS remain unclear. This study ai...

Advancements and future directions in transforming therapies of prostate cancer

ABSTRACT: The treatment landscape for advanced prostate cancer (PCa) has significantly evolved in recent years, marked by the introduction of several novel therapies. Targeting the androgen receptor (AR) remains a cornerstone of treatment, with drugs, such as abiraterone and next...

Blood nutritional and immune indices in lung cancer: a narrative review of prognostic significance, treatment response, and clinical applications

Lung cancer is the No.1 malignant tumor with the highest morbidity and mortality in the world. The prognosis of lung cancer depends not only on the tumor itself and the treatment, but also on the nutritional and immune status of the patients. Nutritional status can affect the qua...

Antihypertensive Treatment and Risk of Metabolic Associated Fatty Liver Disease: A Drug-Target Mendelian Randomization

BACKGROUND: Metabolic dysfunction-associated fatty liver disease, conventionally known as nonalcoholic fatty liver disease (NAFLD), affects over a quarter of the global population and lacks approved pharmacological treatments. We investigated whether elevated blood pressure (BP)...

Long-Retention Fluorescent Probe for Plasma Membrane Imaging and Analysis of Membrane Remodeling

Abstract Reliable fluorescence analysis of plasma membrane (PM) remodeling is often compromised by probe internalization and intracellular redistribution, which can obscure genuine changes in membrane physicochemical properties. Herein, we report NIR-PMP-1, a near-infrared fluore...

Self-efficacy of psychiatric nurses and its influencing factors in Guangdong China

Self-efficacy is a critical factor influencing quality of care, particularly for psychiatric nurses at higher occupational risk; however, research on its current status and influencing factors among the nursing population in China remains scarce. This study aimed to investigate t...

LIDR-TB: large language model-integrated platform for traceable drug repurposing in tuberculosis

Tuberculosis (TB) remains a global challenge exacerbated by the ongoing emergence of drug-resistant strains. Although drug repurposing offers a cost-effective strategy to expedite therapeutic discovery, its application is impeded by the lack of unified, disease-specific framework...

The effectiveness of CBT-based interventions for sleep outcomes in people living with HIV: a systematic review and meta-analysis of randomized controlled trials

To examine the effectiveness of CBT-based interventions in reducing the severity of insomnia, improving sleep quality, and increasing sleep efficiency among people living with HIV. A systematic search was conducted across PubMed, Web of Science, Embase, PsycINFO, Scopus, CINAHL,...

Upcycling Spent Tea Leaves into a Multifunctional Separator for High-Performance and Eco-Friendly Aqueous Zinc-Ion Batteries

Abstract Aqueous zinc-ion batteries (AZIBs) suffer severe limitations from uncontrollable Zn dendrite growth and parasitic side reactions. Separator functionalization is a promising strategy for addressing these challenges. However, modifying cellulose-based separators often invo...

Multiomics analysis reveals putative neural invasion-associated transcriptional signatures of hepatocellular carcinoma

Perineural invasion (PNI) drives tumor progression, local recurrence, and metastasis in pancreatic, prostate, and head/neck cancers. In hepatocellular carcinoma (HCC), the most common primary liver cancer, classical PNI is rarely observed, and the molecular mechanisms governing H...

Association between COVID-19 and exacerbation of allergic skin diseases

Coronavirus disease 2019 (COVID-19) has been linked to systemic immune dysregulation and various cutaneous manifestations, but its association with chronic allergic skin diseases, including atopic dermatitis (AD) and chronic urticaria (CU), remains unclear. This retrospective que...

MH-Penile-002: a phase II, prospective, single-arm trial of neoadjuvant anti-EGFR antibody-drug conjugate plus PD-1 inhibitor in penile cancer with challenging penile preservation or regional lymph node metastasis

Emerging evidence suggests that combinations of antibody-drug conjugates (ADCs) and immune checkpoint inhibitors (ICIs) may be effective for advanced penile squamous cell carcinoma (PSCC). These findings support the translation of this strategy into the neoadjuvant setting, offer...

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated cal...

Enzyme-mimicking peripheral substituents beyond the second coordination sphere tune single-atom catalysts for periodate activation

Abstract Single-atom catalysts (SACs) are promising enzyme-mimetic active centers, yet mimicking long-range regulation by distal binding pockets in natural metalloenzymes remains challenging. Here, we synthesize conjugated organic SACs bearing tunable peripheral substituents beyo...