Sichuan University

Application of information retrieval system based on knowledge graph in education

To solve the problem that the information retrieval system in advanced higher mathematics teaching cannot deeply analyze the logical relationship of complex concepts, theorems, and formulas, which makes it difficult for users to understand the knowledge system fully, this article...

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics. Although mRNA‐based medicines have achieved clear clinical impact in vaccination, broader applications remain limited by mRNA instability, deli...

Recombinant humanized collagen type Ⅲ-modified rapamycin liposomes for promoting osteoarthritis repair

Osteoarthritis (OA), a prevalent chronic degenerative joint disorder, affects hundreds of millions of people worldwide and has become a leading cause of joint pain and functional impairment in middle-aged and elderly populations. It not only severely compromises patients’ quality...

Erythritol Exacerbates DSS-Induced Colitis and Influences Behavioral Responses in Mice Through Gut Microbiota and Metabolic Alterations

Excessive consumption of ultra-processed foods (UPFs) containing non-nutritive sweeteners (NNS) has been implicated in inflammatory bowel disease (IBD), yet the effects of erythritol on intestinal inflammation remain poorly understood. In this study, we assessed NNS-containing UP...

Global Hotspots and Trends in Microbial Plastic Biodegradation for Plastic Waste Management: A Mini-Review and Bibliometric Analysis

The accumulation and persistence of plastic waste have made microbial plastic biodegradation an important topic in pollution control, environmental remediation, and sustainable materials management. This study combines a mini-review with bibliometric analysis to link mechanistic...

Longitudinal dynamics of the maternal gut virome associate with metabolic features of preterm birth

Preterm birth (PTB) remains a major pregnancy complication, yet the role of the maternal gut virome in its etiology is largely unknown. Here we show that the maternal gut virome undergoes ecological destabilization prior to PTB, coupled with distinct host metabolic remodeling. Ne...

Prevalence of disease related malnutrition assessed by NRS2002, STAMP, MNA-SF, one-step and two-step GLIM at admission and discharge: A systematic review and meta-analysis.

BACKGROUND AND OBJECTIVES: Disease-related malnutrition (DRM) mandates routine screening in many nations to ensure quality care as nutritional status often deteriorates during hospitalization. This study aimed to establish tool-specific prevalence benchmarks at admission and disc...

Advances in collagen-based materials for tissue-engineered meniscus

Meniscus possesses weak self-repairability once getting hurt due to heterogeneity, particularly “white region” of avascular parts. However, the effect of conventional therapies in restoring structure and function of the meniscus isn’t ideal. Collagen, a key part of the extracellu...

Soil burial evaluation of finished leather biodegradability: microbial community dynamics and biogeochemical cycles

Biodegradability of finished leather is crucial for the sustainable development of the leather industry. Herein, the biodegradability evaluation system of finished leather was engineered using soil burial degradation, microbial community dynamics, and biogeochemical cycles. The p...

lnc-HOTAIR inhibits MTHFR expression to regulate endothelial cell proliferation and apoptosis in aSAH-induced cerebral vasospasm

Abstract Background: Cerebral vasospasm (CVS) following aneurysmal subarachnoid hemorrhage (aSAH) is a major cause of disability and mortality, yet its pathogenesis remains incompletely understood. long non-coding RNA HOX Transcript Antisense RNA (lnc-HOTAIR) is involved in the r...

Engineering design of cobalt-based biomaterials for advanced cancer theranostics: Multimodal synergy, scalable fabrication, and clinical translation

Despite established modalities such as chemotherapy and radiotherapy, cancer treatment remains hindered by off-target toxicity, drug resistance, and adverse effects. Cobalt-Based Biomaterials (Co-BMs) have emerged as versatile nanoplatforms for tumor theranostics, leveraging reve...

Immobilizing lignin-based carbonized polymer dots onto layered double hydroxides for high-performance supercapacitors with recyclable Fenton-like reactivity

Emerging carbonized polymer dots (CPDs) from natural aromatic-like lignin biopolymer have ignited the renaissance of sustainable nanoscale biomass valorization but are hindered by structural instability and functionality barriers. Herein, we report an interfacial heterostructure...

The cGAS-STING Pathway in Neuroinflammation and Neurological Disease: Mechanisms, Disease Contexts, and Periphery-to-Brain Communication

Neurodegenerative disorders involve a strong inflammatory component, yet the underlying inflammatory mechanisms may be heterogeneous across disease stage, cell type, and systemic context. A key unresolved question is how cellular and systemic stress is converted into sustained ne...

Curving transparent ceramics via force-driven sintering

Transparent ceramics are critical for advanced optics and armor, but shaping them into highly curved geometries without degrading their optical and mechanical properties remains a formidable challenge. Here, we introduce a force-driven sintering strategy that harnesses force-indu...

A New Technique for the Treatment of Ureteral Stricture in Patients with Solitary Kidney

OBJECTIVE: To evaluate the safety and efficacy of the Allium metal ureteral stent (AMUS) in treating ureteral stricture (US) in patients with solitary kidney (SK). PATIENTS AND METHODS: We prospectively collected clinical data from 47 SK patients with US who underwent endoscopic...

The Multi-Layered Effect of Panaxatriol Saponins in Preventing Diabetic Nephropathy in Mice

Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD). Nearly 40% of people with diabetes will develop DN, and DN accounts for 23% of ESRD cases in China. Dysfunction of the gut-kidney axis...

Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning

Abstract Large language models (LLMs) have emerged as important tools in healthcare, showing growing potential for clinical reasoning and patient care. This survey examines recent progress in medical LLMs, focusing on reasoning applications and requirements. We present a dual-vie...