Sichuan University

Radioresistance and tumor recurrence: cellular plasticity, tolerant niches, and therapeutic opportunities

Treatment tolerance remains a primary obstacle to successful radiotherapy, frequently leading to adverse patient trajectories. This review integrates evidence on radiation-induced tolerant niches across temporal windows and biological levels. A distinction is drawn between tumor-...

Myocardial work in light-chain and transthyretin-related amyloidosis with preserved ejection fraction: a cardiovascular magnetic resonance study

Abstract Objectives To investigate pressure–volume loop (PV-loop) changes by cardiovascular magnetic resonance (CMR) imaging in cardiac amyloidosis (CA) patients with preserved left ventricular ejection fraction (LVEF), and to assess PV-loop parameters’ potential as subtype diffe...

From Classification to Cross-Modal Understanding: Leveraging Vision- Language Models for Fine-Grained Renal Pathology

Fine-grained glomerular subtyping is essential for kidney biopsy interpretation, yet it presents a harder setting than the broad organ- or disease-level recognition tasks commonly used in vision-language model (VLM) evaluation. In this task, all categories arise within the same r...

The impact of tranexamic acid on graft function in liver transplantation: A randomised controlled trial

Tranexamic acid (TXA) has been reported to reduce transfusion requirements in liver transplantation (LT). However, clinical evidence regarding the impact of TXA on graft function and other outcomes in liver transplant recipients remains limited. This study aimed to evaluate the e...

Gut microbiota‐derived tryptophan metabolite attenuates calcium oxalate nephropathy by suppressing renal tubular cell apoptosis through the AhR – SOCS3 – STAT1 axis

Calcium oxalate (CaOx) nephropathy is a highly prevalent urological disease worldwide. Gut microbiota dysbiosis and host metabolic dysregulation are recognized as pivotal drivers in disease pathogenesis, yet the underlying mechanisms remain incompletely understood. In this study,...

Machine Learning in Amyloidogenic Polypeptide Research: From Sequence Prediction to Drug Discovery

Abstract Over the past decade, machine learning (ML) has established a transformative paradigm for investigating amyloidogenic polypeptides. Characterized by their propensity to form ordered, β-sheet-rich fibrillar aggregates, these polypeptides are centrally implicated in the pa...

A novel electromagnetic cold crucible-based continuous melting- solidification process for high-purity and highly densified Ti alloy ingots

Titanium alloys are widely used in high-end fields such as aerospace and biomedical engineering due to their outstanding specific strength and excellent corrosion resistance. However, existing titanium alloy ingot preparation technologies generally suffer from high energy consump...

Fixed or flexible: How product formats affect consumer redemption behavior for live-streamed food and beverage (F&B) products

With the rapid growth of live-streaming e-commerce in the food and beverage industry, low redemption rates despite high sales volumes have become a critical challenge for merchants. This research investigates how product formats and familiarity affect consumer redemption behavior...

A lightweight attention-enhanced intrusion detection method for anomalous network traffic analysis

Network intrusion detection in complex traffic environments requires a careful balance between detection performance and computational efficiency, particularly when models are intended for resource-constrained scenarios. Existing deep learning-based intrusion detection methods ca...

Stent-Graft Fracture 18 Years After Hybrid Repair of Thoracoabdominal Aortic Aneurysm: A Possible Risk of Retrograde Reconstruction

We report the case of a patient who underwent hybrid repair for a type V thoracoabdominal aortic aneurysm. The procedure ensured durable aneurysm exclusion and visceral perfusion for 18 years. Eighteen years after surgery, the stent-graft fractured occurred at the visceral artery...

Multi-objective optimization-based design of fin parameters for waste heat recovery equipment

With the intensifying global energy crisis and heightened environmental awareness, developing green industry has become a significant trend. As a critical component for heat exchange, optimizing the structure of heat exchangers holds substantial importance for recovering waste he...

Effect of Duloxetine on the Perioperative Anxiety Status and Stress Response Following Total Hip Arthroplasty: A Randomized Controlled Trial

ABSTRACT Objective The impact of psychological factors on surgical stress response has garnered extensive attention. However, perioperative intervention strategies are still lacking for the total hip arthroplasty (THA) population without psychiatric comorbidities. This study aime...

Modified Xiaoyaosan Regulates the Neuro-Immune Microenvironment in Chronic Stress: A Preclinical Meta-Analysis and NF-kappaB Pathway Mechanism Exploration

Background: Chronic unpredictable mild stress (CUMS) triggers systemic pathologies, notably depression and endocrine disorders such as hyperprolactinemia (HPRL). Xiaoyaosan (XYS), a classic traditional Chinese medicine formulation, has been proven effective in treating these stre...

Static-dynamic triggering mechanisms of rockburst in straight-walled arch roadways under different principal stress orientations and impact disturbances

This study investigates how principal-stress orientation affects impact disturbance triggered rockburst around straight-walled arch roadways. Coupled static-dynamic loading tests were conducted on specimens containing a straight-walled arch opening with orientation angles of 0°,...

Effect of adjunctive minocycline on functional recovery and safety in acute ischemic stroke: a systematic review and meta-analysis

Neuroinflammation drives secondary brain injury after acute ischemic stroke. Minocycline, a tetracycline antibiotic with anti-inflammatory properties, has shown promise in preclinical and early-phase trials. The recent EMPHASIS trial necessitates an updated evidence synthesis. We...

Age-Associated Differences in Facial Skin Structure in Chinese Women: a Cross-Sectional Study

Facial skin aging is a process leading to structural degradation and visible phenotypical changes. Prior studies examined age-related skin parameters and suggested accelerated changes occurring in the early 30s, yet precise timing remains insufficiently defined, and few assessed...

Micro-Water Migration Characteristics in Cable Oil-Filled Terminations and Their Effect on Insulation Performance

To investigate moisture ingress in the insulation of cable oil-filled terminations, this study first simulated moisture migration within a termination. Based on identified accumulation locations, the breakdown voltage of the silicone rubber (SiR)/cross-linked polyethylene (XLPE)...

Exploratory thyroid ultrasound–computed tomography synthesis using anatomy-preserving contrastive unpaired translation

OBJECTIVES: When ultrasound (US) and computed tomography (CT) are both clinically indicated, unpaired image translation may support model development but cannot replace either examination. We evaluated Anatomy-Preserving Contrastive Unpaired Translation (AP-CUT), a CUT-based fram...

Triple-Cross-Linked Seawater-Sourced Hydrogels with Extreme Thermo-Shear Stability for Ultradeep Marine Reservoir Exploitation

Abstract Hydrogels play an important role as materials in the oil and gas industry. Direct preparation of hydrogels using seawater is attractive for offshore energy production but remains challenging because conventional partially hydrolyzed polyacrylamide with a single-cross-lin...

Near-neutral flotation of microfine ilmenite

Conventional ilmenite flotation strongly relies on sulfuric acid to improve the selectivity between ilmenite and associated gangue minerals, resulting in high reagent consumption, equipment corrosion and difficulties in process water recycling. In this study, a ternary Fe-BHA/NaO...