Sichuan University

BIRC3 facilitates osteogenic differentiation of bone marrow mesenchymal stem cells via NGFR/β-catenin signalling axis

Aims: Osteoporosis primarily results from age-related declines in bone marrow mesenchymal stem cell (BMSC) differentiation into osteoblasts; however, the regulatory mechanisms remain unclear. Methods: Integrated analysis of Gene Expression Omnibus (GEO) and RNA sequencing (RNA-se...

Ectopic thyroid tissue accompanied by distinct blood supply and lymphoid tissue within the carotid sheath - a case report

Rationale: Ectopic thyroid tissue (ETT) is not extremely rare, but it may be overlooked in clinical practice because of its frequently asymptomatic presentation, lack of urgency for diagnosis, and limitations in diagnostic techniques. We report a case of ETT within the carotid sh...

Next-generation natural killer cell therapy: bench to bedside and beyond

Natural killer (NK) cells have emerged as central players in cancer immunotherapy, progressing from basic discovery to clinically validated platforms over five decades. This review synthesizes the evolving understanding of NK cell biology, including subset heterogeneity, epigenet...

Ocular Gene Therapy in China: Technological Framework, Clinical Translation, and Future Perspectives

The eye is well suited to gene therapy because of its compartmentalized anatomy, accessibility for local delivery, and capacity for longitudinal assessment. In China, ocular gene therapy is undergoing rapid clinical translation, with expanding innovation in vector engineering, de...

Effects of Ketamine and Esketamine on Postoperative Delirium After General Anesthesia: A Meta-Analysis and Meta-Regression Analysis

BACKGROUND: Postoperative delirium (POD) is a frequent and serious complication, particularly in older adults undergoing major surgery. Pharmacologic prevention remains limited. This study aimed to evaluate whether perioperative ketamine or esketamine reduces POD incidence and to...

Abrupt permafrost thaw overwhelms vegetation-driven erosion reduction in sediment export on the Tibetan Plateau

Vegetation greening and abrupt permafrost thaw are reshaping sediment dynamics across the Tibetan Plateau, yet their relative effects on sediment delivery remain poorly quantified. Here we show that retrogressive thaw slumps are disproportionately important sediment sources, with...

Clinical performance of obstetric antiphospholipid syndrome classification criteria: an ambispective cohort study

Abstract Objectives To evaluate the clinical performance of the 2006 Sydney and 2023 ACR/EULAR classification criteria for obstetric antiphospholipid syndrome (OAPS), compare subsequent pregnancy outcomes across classifications and develop a supplementary classification method to...

The Application Potential and Future Challenges of Plant-Derived Exosome-like Nanoparticles in the Treatment of Liver Diseases

Liver disease is a serious global health challenge, with high morbidity and mortality that put significant socioeconomic stress on society. Despite therapeutic advances, current regimens have been limited by rapid drug resistance and insufficient targeting accuracy, and there is...

Programmable Temperature‐Capped Dressing for Enhanced Wound Healing, Bacterial Clearance, and Inflammatory Modulation

ABSTRACT Reconciling efficient bacterial eradication with tissue safety remains a challenge in photothermal therapy (PTT) because of open‐loop thermal actuation. Herein, we propose a detachable bilayer hydrogel dressing comprising a poly(N‐isopropylacrylamide) (PNIPAM)‐based prot...

Development of a Potent and Isoform-Selective HDAC11 Inhibitor with Anti-Tumor Efficacy against Non-Small Cell Lung Cancer

Abstract Targeting histone deacetylase 11 (HDAC11) represents a promising therapeutic strategy, yet developing selective inhibitors for solid tumors remains a formidable challenge. Herein, we describe the rational lead optimization of a novel series of indole-based hydroxamic aci...

Black‐Cat Markets: Superstitious Beliefs, Extreme Events, and Housing Prices in China

ABSTRACT This paper examines the extent and persistence of numerological superstitions in China's housing market. We focus on the numbers “4” and “8,” given the strong negative and positive cultural beliefs associated with them. Using an extensive dataset of new apartment transac...

Radon Exposure: A Comprehensive Review of the Health Risks and Therapeutic Potentials

Radon, a naturally occurring radioactive gas, is classified as a Group 1 carcinogen by the World Health Organization (WHO) and remains a significant environmental health hazard. Traditionally linked to lung cancer, radon exposure is the second leading cause of lung cancer worldwi...

Risk-Adaptive Hierarchical Coordination for Supply Security in Renewable-Dominated Multi-Area Power Systems

Against the background of high penetration of renewable energy, multi-area power systems are exposed to risks arising from renewable generation variability, load forecast deviations, and multi-factor supply–demand disturbances under extreme conditions. To enhance power supply sec...

Stress Regulation through Precursor Chemistry: From Synthesis to Cycling Stability in O3‐Type Layered Oxide Cathodes

ABSTRACT Layered oxide cathode materials have broad application prospects in sodium‐ion batteries. However, conventional oxide solid‐state synthesis route, transition metal oxides slowly participate in the reaction step by step, causing residual stress accumulation and cycling de...

Group Theory-Guided Orbital Symmetry Engineering of cis -Quinacridone: From Symmetry-Forbidden to Dipole-Allowed Transitions for Efficient Narrowband Emissions

Abstract Although group theory is widely used to analyze symmetry and electronic transition selection rules in condensed matter physics and coordination chemistry, its use as a predictive design tool for organic light-emitting diodes (OLEDs) remains largely unexplored. This is pa...

Transparent Ultraviolet-Shielding Poly(ester amide) Elastomers with Excellent Elastic Recovery via Hydrogen-Bonding Compensation

Abstract Developing sustainable elastomers that synergistically integrate intrinsic ultraviolet (UV) shielding, high elasticity, and optical transparency remains a fundamental challenge, as rigid chromophores essential for UV absorption inherently compromise network dynamics and...

Federated Distillation: A Survey

Federated learning (FL) enables collaborative model training without centralizing clients’ raw data, but parameter exchange can impose substantial communication costs and usually requires compatible model architectures. Federated distillation (FD) instead transfers predictive or...

Evaluation of Rare MCOLN1 Variants in a Large Cohort of α‐Synucleinopathies

Note: Genomic position was based on GRCh37.Variants were classified according to the 2015 American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP) joint consensus guidelines, with P indicating that the variant is pathogenic.Function p...

VGLL4 Suppresses Malignant Phenotypes of Clear Cell Renal Cell Carcinoma Cells Through Modulation of Hippo/YAP and Wnt/β-Catenin Signaling Pathways

Background/Objectives: Clear cell renal cell carcinoma (ccRCC), the most common and aggressive subtype of kidney cancer, continues to face challenges in early diagnosis and treatment, driving the need for reliable biomarkers and therapeutic targets. Vestigial-like family member 4...

Iridium-Catalyzed Asymmetric Hydrogenation of Pyridazine Salts under Batch and Flow

Abstract Herein, we report an [Ir(COD)Cl]2/(R)-SunPhos-catalyzed asymmetric hydrogenation of pyridazine salts to construct chiral hexahydropyridazines. The reaction tolerates a wide range of substituents, delivering products in up to 97% yield with 97% ee under mild reaction cond...