Institution
Sichuan University
Recent research
- Biology
Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The integration of anti-PD-1 antibody therapy with chemotherapy has shown promising results in the neoadjuvant treatment of locally advanced esophageal squamous cell carcinoma. Conventional imaging m...
- Materials & Energy
Three-dimensional (3D) printing enables the precise design of biomaterials at predefined spatial locations, representing a promising strategy for constructing highly organized osteochondral tissue with multiple morphogen gradients. However, most current 3D printing strategies lim...
- Materials & Energy
ABSTRACT Semisaturated heterocycles are privileged scaffolds in natural products and pharmaceuticals, yet a general and versatile catalytic strategy to access these chiral architectures remains a formidable challenge. Herein, we report a unified synthetic platform utilizing the e...
- Engineering & Technology
ABSTRACT Biomimetic technology has high potential for enhancing cancer immunogene therapy. Cell membrane‐coated nanoparticles (CMNPs) obtain extra targeting, recognition, and signaling transduction functions. However, a single kind of CMNPs is limited when facing complicated tumo...
- Materials & Energy
ABSTRACT Semisaturated heterocycles are privileged scaffolds in natural products and pharmaceuticals, yet a general and versatile catalytic strategy to access these chiral architectures remains a formidable challenge. Herein, we report a unified synthetic platform utilizing the e...
- Health & MedicineOpen access
This network meta-analysis (NMA) analyses the latest evidence to evaluate perioperative and postoperative outcomes between minimally invasive surgery (MIS), including robot-assisted (RA) and laparoscopic (LA) approaches, versus open (OA) radical surgery for hilar cholangiocarcino...
- Health & MedicineOpen access
Older adults with sepsis have high mortality, but whether circulating immune-inflammatory biomarkers improve prediction beyond routine clinical information across hospitals is uncertain. We analysed 816 patients aged ≥ 60 years from a prospectively assembled multicentre cohort at...
- Health & Medicine
Abstract Topic Benign Disease: Barrett’s Esophagus: Pathology and Pathophysiology; Non-invasive Neoplasia Background Gastroesophageal reflux disease (GERD), Barrett’s esophagus (BE), and esophageal adenocarcinoma (EAC) form a recognized pathological continuum, but the causal immu...
- Engineering & Technology
Abstract Low-grade heat (<373 K) remains an underutilized energy source due to inefficient conversion technologies. While ionic thermoelectric (i-TE) materials show promise for direct thermal-to-electrical energy conversion, simultaneously optimizing the conductivity and Seebeck...
- Climate & Environment
Recent Increaseof Greenhouse Gas Emissions from Cryosphere-InfluencedReservoirs under Climate Change
Abstract Global warming leads to cryosphere degradation, transferring large amounts of terrestrial carbon and nitrogen to reservoirs, which may accelerate the release of greenhouse gases (GHGs) to the atmosphere. However, the spatial dynamics and decadal trends of GHG emissions f...
- Health & Medicine
Rosemary extract (E392) in main Chinese foods and associated health risk
This study assessed the application of rosemary extract (E392) in foods and estimated dietary exposure in China, using a stepwise approach, encompassing theoretical maximum use, enterprise-reported usage, and product-level monitoring. Exposure assessments combined national dietar...
- Materials & Energy
Weak Acceptors Abnormally Reinforce Urethane Networks while Enabling Glassy-State Healability
Abstract Hydrogen bonds are versatile motifs for designing repairable materials. The current preconception is that while weak hydrogen bonds lead to rapid exchanging dynamics beneficial for healing, they compromise mechanical properties by reducing the overall cohesion of the mat...
- Health & MedicineOpen access
Abstract Accumulating evidence has suggested that depression is associated with an increased risk of Parkinson’s disease (PD), yet whether pre-clinical depressive symptoms in PD development and the potential mediating effects of metabolomic profiles remain unclear. We aimed to ex...
- Health & MedicineOpen access
Social alienation severely impairs the mental health and quality of life of patients undergoing maintenance hemodialysis (MHD). However, most studies conducted have been variable-centered, group-level analyses, which cannot capture inherent heterogeneity in social alienation, hin...
- Engineering & Technology
ABSTRACT A fatal issue of zinc‐based electrochemical energy storage (ZEES) is uneven Zn 2+ deposition and rampant dendrite growth on the zinc metal anode, which significantly reduces the lifespan and reliability of ZEES devices. This work reports a cellulose tissue (CT) based sep...
- Climate & EnvironmentOpen access
Energy independence is a cornerstone of national sovereignty, increasingly dependent on renewable energy development. Yet structural inequalities rooted in colonial history, institutional path dependence, and global innovation barriers shape the effectiveness of technology-enable...
- Health & MedicineOpen access
Adding anti-PD-1 or anti-VEGF therapy to chemotherapy improves survival in patients with advanced gastric cancer, yet outcomes remain poor. This Phase Ib/II trial aimed to evaluate the efficacy and safety of combining sintilimab, the bevacizumab biosimilar IBI305, and CapeOX chem...
- Biology
Abstract In this work, the protective mechanism of exopolysaccharide (EPS) on Lacticaseibacillus rhamnosus during freeze-drying was revealed through physiological, proteomic, and molecular dynamics simulation analyses. Physiological analysis suggested that the addition of EPS cou...
- Health & MedicineOpen access
A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...
- BiologyOpen access
Mechanistic basis of LolDF-mediated lipoprotein transport in Acinetobacter
Lipoprotein trafficking is essential for Gram-negative bacteria to maintain the outer membrane, a permeability barrier critical for survival and antibiotic resistance. While most bacteria employ the canonical LolCDE transporter, Acinetobacter utilizes a noncanonical LolDF system...