Shanghai Jiao Tong University

Integrated nutrient management, soil biological functions, and their linkages with fruit quality in mango (Mangifera indica L.) under medium-density planting

Integrated nutrient management (INM) combining reduced recommended fertilizer doses (RDF) with foliar micronutrients may improve soil health and fruit quality in tropical mango orchards. This study evaluated INM strategies for soil properties, plant nutrient status, and fruit qua...

Exercise-associated transcriptomic profiling identifies Ticam2 as a candidate therapeutic target in a SOD1G93A mouse model of amyotrophic lateral sclerosis

Exercise may slow disease progression in amyotrophic lateral sclerosis (ALS), but the molecular mechanisms underlying its protective effects remain unclear. Here, voluntary wheel running prolonged survival in male SOD1 G93A mice. To identify potentially actionable molecular targe...

Drought amplifies the impact of vegetation phenology on wildfire in Guizhou Province, China

Vegetation phenology is highly sensitive to climate change and may influence wildfire by regulating fuel accumulation and fuel moisture. However, under increasingly frequent extreme droughts, clear evidence is still lacking regarding how phenological changes affect wildfires acro...

Recalibrating copyright liability for recommender platforms: Safe harbour, managed visibility, and tiered duties

This article asks how copyright liability should be recalibrated when short-video platforms do not merely host user uploads but manage their visibility through recommender systems. It argues that recommendation-amplified infringement exposes a structural mismatch between legacy s...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

PTBP1‐Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop

ABSTRACT Background : Everolimus (EVE) is a key treatment for advanced clear cell renal cell carcinoma (ccRCC), mainly targeting AKT/mTOR signaling. However, developed resistance remains a major challenge for EVE treatment. Aberrant alternative splicing, particularly regulated by...

Targeting the NOTCH1 signaling pathway in chronic lymphocytic leukemia enhances the efficacy of CD19 CAR-T cells

Abstract Background The therapeutic efficacy of chimeric antigen receptor T (CAR-T) cells targeting CD19 in chronic lymphocytic leukemia (CLL) treatment can be limited by target cell antigen loss. This study aims to elucidate how the intrinsic NOTCH1 signaling activity in CLL cel...

Effect of silica-to-alumina ratio on hydrocarbon adsorption–desorption properties of Ag/ZK-5 Zeolites for gasoline cold-start emission control

Cold-start hydrocarbon (HC) emissions from gasoline engines remain a critical challenge in automotive exhaust purification, as three-way catalytic converters remain inactive below their light-off temperature. Ag-modified zeolites are promising HC trap materials, yet the structure...

The Strong Electronic Metal–Support Interactions Mediated Direct Three‐Electron Oxygen Reduction for Enhanced Hydroxyl Radical Generation

ABSTRACT Hydroxyl radical (·OH) production in the traditional electro‐Fenton process relies on the two‐electron oxygen reduction reaction (2e − ORR) to generate H 2 O 2 , followed by activation by ferrous ions, suffering from low efficiency and mass‐transfer limitations. Herein,...

Cryo‐EM Structures of Sunflower Amyloid Fibrils Reveal Two Distinct Disulfide‑Linked Assembly Modes

ABSTRACT Sunflower meal is an abundant but underutilized plant protein source. Recent studies have demonstrated that its amyloid fibrils exhibit exceptional functional properties, yet the atomic‐level structural basis remains unknown. The first cryo‑electron microscopy (cryo‑EM)...

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

ABSTRACT Limited aqueous dispersibility and potential off‐target toxicity hinder the development and clinical translation of proteolysis‐targeting chimeras (PROTACs). Herein, a bioactive self‐delivering “Split Nano‐Assembly of Photosensitizers and Targeting Chimeras” (SNAP‐TAC) t...

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

ABSTRACT Coronaviruses have persistently triggered global pandemics in the 21 st century, featuring either high transmissibility or high pathogenicity. A hallmark of these infections is the delayed activation of innate immune responses, resulting in dysregulated antiviral signali...

Full-process control enables emissions trading to promote synergistic reductions in carbon emissions and pollution in China

This study examines the entire process of carbon and pollution reduction and assesses the effects of the emissions trading scheme (ETS) on the integrated outcomes of carbon and pollution reduction. The findings indicate that the introduction of the ETS not only leads to a decreas...

Unveiling the Critical Binder Requirements for High-Energy-Density Silicon-Based Pouch Cell

Abstract Silicon is gradually replacing graphite as a novel anode material for high-energy-density lithium-ion batteries. However, the substantial volume changes of silicon during lithiation/delithiation make the anode binder, which maintains electrode structural stability, criti...

A positive feedback loop between HNRNPF and GRHL2 drives NEK8-mediated prostate cancer progression

Prostate cancer (PCa) remains a major cause of cancer-related mortality in men, especially in advanced stages. The role of Heterogeneous Nuclear Ribonucleoprotein F (HNRNPF) in PCa progression is poorly defined. The function and mechanism of HNRNPF were investigated using in vitr...

Protocol to prepare PARPi-combined LIN28B siRNA nanoparticles and evaluate therapeutic efficacy of malignant ascites

Malignant serous effusion (MSE) is a life-threatening complication of advanced cancers with limited effective treatments. Here, we present a protocol for the preparation of LIN28B siRNA-loaded nanoparticles and their combination with PARP inhibition for therapeutic evaluation in...

Stabilizing Pt by Introducing TaON to Enhance the Long-Term Stability in Zinc-Air Batteries

Abstract For many years, the application of zinc-air batteries (ZABs) has been plagued by the limited durability of platinum (Pt)-based catalysts. Here, we overcome this problem by adopting an intelligent catalyst design, introducing tantalum (oxy)nitrides (TaON) as a carrier to...

An improved three-dimensional thermal multiple-relaxation-time lattice Boltzmann model for liquid-vapor phase change

In this paper, an improved three-dimensional (3D) thermal multiple-relaxation-time (MRT) lattice Boltzmann (LB) model is proposed for the temperature field and coupled with a 3D central-moment pseudopotential LB model for the flow field to simulate liquid-vapor phase change, with...

Circulating ANGPTL4 predicts CKD and ESKD risk: insights from large-scale proteomics and senescence mechanisms

Abstract Background The global burden of chronic kidney disease (CKD) is increasing significantly, with aging recognized as a major risk factor associated with accelerated biological aging and poor renal outcomes. Growing evidence links angiopoietin-like protein 4 (ANGPTL4) to bo...

Toward Iron-Biofortified Rice: Integrating BRUTUS-Family Regulation and Iron Chaperone Biology

Abstract Rice is both a leading model for cereal molecular genetics and one of the world’s most important staple foods, which makes it a decisive crop for iron (Fe) biofortification. However, the breeding goal is not simply to increase total plant Fe or even total grain Fe. For p...