Shanghai Jiao Tong University

Toward Iron-Biofortified Rice: Integrating BRUTUS-Family Regulation and Iron Chaperone Biology

Abstract Rice is both a leading model for cereal molecular genetics and one of the world’s most important staple foods, which makes it a decisive crop for iron (Fe) biofortification. However, the breeding goal is not simply to increase total plant Fe or even total grain Fe. For p...

Full-process control enables emissions trading to promote synergistic reductions in carbon emissions and pollution in China

This study examines the entire process of carbon and pollution reduction and assesses the effects of the emissions trading scheme (ETS) on the integrated outcomes of carbon and pollution reduction. The findings indicate that the introduction of the ETS not only leads to a decreas...

Myocardial tissue characteristics assessed by multiparametric CMR in hyperthyroid patients with suspected cardiac involvement

Abstract Background Hyperthyroidism is reportedly associated with increased cardiovascular risk and heart failure. However, a definite association between hyperthyroidism and cardiomyopathy has not been reported. This study aimed to analyze alterations in myocardial tissue charac...

Embodied Sensing for Closed-Loop Manipulation in an Integrated Magnetic Soft Robot

Abstract Precision manipulation of magnetic soft robots holds great promise for applications in complex and confined environments, where a single robot could perform diverse tasks on different target objects. However, existing sensing strategies predominantly emphasize the detect...

Multiomics analysis reveals super enhancer associated GTSF1 and Schwann cell heterogeneity in neuroblastoma

Super-enhancers (SEs) contribute to oncogenic transcriptional programs in neuroblastoma (NB), but their relationship with nerve-associated microenvironmental remodeling remains unclear. This study integrated epigenomic, transcriptomic, dependency, single-cell, and clinical valida...

Co-optimization of park-level electricity-heat-hydrogen integrated energy systems with reversible solid oxide cells

Reversible solid oxide cells (rSOCs) enable bidirectional energy conversion in integrated energy systems; however, their system-level value under diverse renewable conditions remains unclear. This study develops a mixed-integer nonlinear programming (MINLP) framework for joint ca...

Synergistic effect of the warm plasma discharge and the flow field on the ammonia/air premixed combustion stabilization near the lean blowout limit

This work investigates the synergistic effect of the warm plasma discharge and the flow field on the ammonia combustion stabilization under different discharge powers and swirl numbers by a novel contribution analysis method that integrates the numerical simulation with a theoret...

Bulk 1T-NbSe2 Superconductor Stabilized by the Doped Ti-3d0 Electronic Configuration

Abstract Metastable 1T-phase transition-metal dichalcogenides host rich strongly correlated electronic phenomena, yet the synthesis of bulk 1T-NbSe2 remains a challenge. This difficulty stems from the energetic penalty associated with the octahedral coordination of Nb4+, whose 4d...

Motion responses and flow field characteristics of a CFPSO with complex heave plates under regular waves

Cylindrical floating production storage and offloading (CFPSO) units are widely recognized as superior platforms in the field of offshore oil and gas engineering. Practical engineering applications show that heave plates not only have significant effects on heave motion, but also...

NAT-A exhibits anti-tumor activity against acquired epidermal growth factor receptor- tyrosine kinase inhibitor-resistant non-small cell lung cancer via inhibiting the β-catenin/PKM2 axis

Hyperactivation of the Wnt/β-catenin pathway is a key driver of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistance in non-small cell lung cancer (NSCLC), with pyruvate kinase M2 (PKM2) serving as a critical transcriptional coactivator of β -catenin....

Clinical characteristics and influencing factors of children with MT-TL1 gene m.3243 A > G mutation: a phenotypic study based on 11 Han Chinese patients

The m.3243 A > G mutation in the MT-TL1 gene is one of the most common mitochondrial DNA variants, associated with a broad range of clinical phenotypes. While its manifestations in adults have been widely reported, data on pediatric presentations remain limited, particularly in A...

Disparities in Cancer Incidence by Sex and Associated Lifestyle Factors and Health Conditions

Importance Cancer risk is higher in males than females globally. Whether this sex disparity reflects a biological inevitability or is potentially modifiable by lifestyle behaviors and health conditions across diverse populations remains unclear. Objective To determine the contrib...

Postnatal sensorimotor experience causally shapes hemispheric specialization across motor and language networks

The functional organization of the human brain is shaped by the interplay between innate constraints and postnatal experience. Hemispheric specialization, as a fundamental organizing principle of brain function, raises unresolved questions about how postnatal experience shapes la...

Quantitative Features of Neovascularization in Fibrotic Age-Related Macular Degeneration and Their Associations With Visual Changes After a Single Anti-VEGF Therapy

Background: Macular fibrosis represents an advanced manifestation of neovascular age-related macular degeneration (nAMD), but active neovascularization may persist within fibrotic lesions. Reliable biomarkers for predicting short-term visual changes after anti-vascular endothelia...

ROOTS: recognizing oracle bone inscriptions via an organized tree structure

Oracle bone inscription recognition is hindered by long-tailed class distributions and strong inter-class visual similarity. Existing augmentation and re-weighting methods modify samples or optimization while retaining competition within a flat label space. We propose ROOTS (Reco...

Quantum Simulation of Multiscale Linear Transport Equations via Schrödingerization and Exponential Integrators

In this paper, we present two Hamiltonian simulation algorithms for multi scale linear transport equations, combining the Schrödingerization method [S. Jin, N. Liu and Y.Yu, Phys. Rev. Lett, 133(2024), 230602][S. Jin, N. Liu and Y.Yu, Phys. Rev. A, 108 (2023), 032603] and exponen...

2D materials with rational design: Advancing electro- and photocatalytic CO2 reduction

CO 2 conversion is central to closing the anthropogenic carbon cycle. However, practical CO 2 RR remains limited by slow molecular activation, competing hydrogen evolution, and dynamic catalyst evolution under operating conditions. Two-dimensional (2D) materials are well suited t...

Association of lipid-frailty composite indices with cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: evidence from the UK Biobank and CHARLS

Non-traditional lipid indices have been increasingly investigated as predictors of cardiovascular disease (CVD) risk, and frailty reflects cumulative physiological decline. Whether integrating these complementary dimensions improves CVD risk prediction remains unexplored. We aime...

Current-Enhanced Tribovoltaic Nanogenerators Based on Dynamic Schottky Junctions Using SWCNT-Induced Local Electric-Field Effect

Abstract Direct-current tribovoltaic nanogenerators (DC-TVNGs) based on dynamic semiconductor junctions can generate electrical output without external rectification. However, their scalable application is constrained by the substantial decrease in current output with increasing...

Large language models for patient-centred evidence generation and use

Preprint. Not peer reviewed. For people with multimorbidity, disease-specific evidence can leave practical questions unanswered. We propose an evidence operating system (Evidence OS) that follows patient priorities through evidence synthesis, research and the return of findings t...