Shanghai Jiao Tong University

Multivalent antiviral conjugates enhance activity against Influenza via cross-linking viruses

Abstract Long-acting drug–Fc conjugate (CD388) has emerged as a new class of antivirals against influenza A and B, yet the mechanisms governing how Fc conjugation reshapes small-molecule function remain undefined. Here we establish a programmable multivalent antiviral conjugates...

Experimental investigation on a low dew point dehumidification system with temperature and pressure swing adsorption using desiccant coated heat exchanger

The supply of low-humidity dry air with a dew point below −30 °C mainly relies on desiccant wheels (DW) and adsorption towers (AT), while the high regeneration temperature and adsorption pressure result in substantial energy consumption. This study proposes a low dew point dehumi...

A hybrid framework combining enhanced fields and consistent spatial features for stroke lesion segmentation in MR images

Stroke lesion segmentation plays a critical role in clinical diagnosis, prognosis and rehabilitation treatment. However, this task remains highly challenging due to inter-subject differences, shape variations, noise and artifacts in MR images, which hinder the accurate extraction...

Niche Divergence-Based Identification of Microbial Indicators Tracking Cyanobacterial Bloom Succession: A Metagenomic and Machine Learning Framework

Abstract Cyanobacterial harmful algal blooms (CyanoHABs) pose significant environmental and public health risks through toxin production, antibiotic resistance gene dissemination, and the disruption of biogeochemical cycles. Although extensive metagenomic investigations have expl...

Food-Specific Challenges and Stabilization Strategies for Replacing Synthetic Pigments with Natural Pigments

Abstract Driven by regulatory restrictions, clean-label trends, and health concerns, the food industry is transitioning from synthetic to natural colorants. This review analyzes this transformation, first outlining key drivers reshaping the food coloring landscape. It then evalua...

Following patient questions across clinical and evidence services with large language model assistance

Preprint. Not peer reviewed. For people with multimorbidity, completing an evidence task does not ensure that the question raised in care has been answered. We propose requirements for following an individual patient question across clinical and evidence services. A continuing re...

Physics-Guided Modeling and Artificial Intelligence for Proton Exchange Membrane Fuel Cells in Extreme Environments

Abstract Proton exchange membrane fuel cells (PEMFCs) deployed in aviation, underwater, and space applications encounter different combinations of environmental and mission constraints. These include altitude-dependent oxygen supply, flight-load transients, closed reactant loops,...

The GPU Resilience Lottery: Understanding and Taming Real-World Hardware Errors in Heterogeneous AI Infrastructure

The booming LLM demand is driving a rapid increase in the scale and heterogeneity of modern AI infrastructure. To achieve high availability for sustained LLM workloads, infrastructure providers must contend with frequent and severe hardware errors. Without a holistic resilience u...

Following patient questions across clinical and evidence services with large language model assistance

Preprint. Not peer reviewed. For people with multimorbidity, completing an evidence task does not ensure that the question raised in care has been answered. We propose requirements for following an individual patient question across clinical and evidence services. A continuing re...

Clifford Disentanglers for Entanglement Reduction in Molecular Electronic Structure Simulations

Abstract Entanglement is a key bottleneck limiting the efficiency of tensor-network and quantum simulations of molecular electronic structure. Here, we systematically assess and extend Clifford disentanglers as a structure-preserving approach to entanglement reduction: they can m...

A boundary-coupled unified frictional hysteresis model for metal rubber under quasi-static and dynamic loading

Metal rubber (MR) contains numerous internal contact, sliding, and frictional interfaces among metallic wires, which leads to pronounced nonlinear and hysteretic characteristics under quasi-static and dynamic loading conditions. Existing hysteresis models are mostly developed for...

Monofluoromethylphenylalanine: A Sensitive 19F Probe for Protein Conformational Dynamics In Vitro and in Cells

Abstract The combination of site-specific incorporation of 19F-labeled unnatural amino acids (UAAs) and 19F nuclear magnetic resonance (NMR) spectroscopy is a powerful strategy for investigating protein structure, dynamics, and interactions. However, commonly used 19F-containing...

Dynamic Flexibility Duration Assessment of Low-Voltage Feeders Using Multi-Feature Trajectory Similarity Matching

Increasing distributed energy resource penetration makes low-voltage feeder flexibility highly time-varying and uncertain, limiting the operational value of static capacity-based estimates. This paper proposes a dynamic flexibility duration assessment framework using multi-featur...

Plasmonic Nature of the “Blue State” in the WO3 Photoelectrode: Carrier Dynamics and Its Impact on Photoelectrochemical Water Oxidation

Abstract This study discusses the photophysical nature of the commonly observed “blue state” in WO3 photoanodes during photoelectrochemical water splitting. We demonstrate, using ultrafast transient absorption spectroscopy, that photoexcitation of the blue state of WO3, generated...

Different concentrations of atropine in children with high myopia: a 2-year multicenter double-blind, randomized controlled trial

High myopia in children risks irreversible visual impairment, yet optimal interventions remain debated. This multicenter double-blind, randomized-controlled trial aims to evaluate the effect and safety of different atropine eyedrops for myopia control in children with high myopia...

Prostaglandin E2-mediated aging microenvironment fuels pathogenic fibrosis in cesarean section scar defect

Abstract With the increasing rates of cesarean section (CS), cesarean section scar defect (CSD) has become an escalating clinical concern due to uterine dysfunction and reduced fertility. However, the biological basis of CSD remains poorly understood, particularly the mechanisms...

Digital communication and narrative governance in BRICS healthcare: a website media analysis of public hospital vision and mission statements

Abstract: This study conducts a qualitative thematic analysis of vision and mission statements from leading publicly listed hospitals in BRICS countries-Brazil, Russia, India, China, and South Africa-to explore institutional health priorities and strategic orientations. Drawing o...

Consensus recommendations for neurofibromatosis type 1 management in Asia Pacific

Neurofibromatosis type 1 (NF1) is a complex multisystem disorder requiring coordinated multidisciplinary care. This study aimed to develop consensus recommendations for NF1 management in the Asia-Pacific region. A modified Delphi process involving two survey rounds and a virtual...

Test vs Mutant: Adversarial LLM Agents for Robust Unit Test Generation

Software testing is a critical, yet resource-intensive phase of the software development lifecycle. Search-based approaches typically achieve high coverage but produce tests with low readability, whereas large language model (LLM)-based methods generate more human-readable tests...

RRM2/GCH1 signaling decreased cisplatin sensitivity in cervical cancer by modulating the ferroptosis process.

BACKGROUND: Cisplatin-based chemotherapy serves as a fundamental approach in the treatment of cervical cancer; however, its effectiveness is often hindered by the development of drug resistance, which presents a significant obstacle in clinical practice. METHODS: studies were car...