Shanghai Jiao Tong University

Pareto Frontier of Neural Quantum States: Scalable, Affordable, and Accurate Convolutional Backflow for Strongly Correlated Lattice Fermions

The recent development of Neural Quantum States (NQS) has established them as one of the most accurate methods for studying strongly correlated many-fermion systems, outperforming existing many-body approaches for large systems. However, NQS calculations are currently highly reso...

HCCO Nanoreactor-Integrated Electrochemical Paper-Based Analytical Device for Anti-EBNA1 IgA Detection toward Nasopharyngeal Carcinoma Screening

Abstract Serological detection of anti-Epstein–Barr virus nuclear antigen 1 immunoglobulin A (anti-EBNA1 IgA) is clinically relevant to nasopharyngeal carcinoma screening, but conventional immunoassays rely on centralized instrumentation and multistep procedures. Here, we develop...

ENOPH1 orchestrates KRASG12D/G13D-driven glycolytic reprogramming and colorectal cancer progression through modulating the TGF-β/SMAD pathway

Oncogenic KRAS mutations (G12D/G13D) drive metabolic reprogramming in colorectal cancer (CRC), yet targetable downstream effectors remain poorly defined. Here, we identify enolase-phosphatase 1 (ENOPH1) as an essential transducer directly upregulated by the KRAS–MEK–ERK axis. ENO...

Strain Coupled (110)-Oriented Lithium Anodes for High-Rate and High-Capacity Epitaxial Growth

Abstract Lithium metal is considered as the ultimate anode for high-energy-density batteries, yet its practical realization is thwarted by dendrite proliferation and chemomechanical interfacial instability. While epitaxial growth on crystallographically textured substrates provid...

Climatology and mechanisms of low-level jets over southeastern coast of mainland China during the early-summer rainy season

Abstract Low-level jets (LLJs) significantly impact early-summer rainy season over the southeastern coast of mainland China (SECC), yet northerly LLJs over this region remain understudied compared to their southerly counterparts. Utilizing decade-long hourly ERA5 reanalysis, this...

Hierarchical multi-market coordination of virtual power plants via multi-factor differentiated bidding

With the increasing participation of distributed energy resources and the growing importance of carbon and flexibility services, virtual power plants (VPPs) require market bidding and revenue-allocation mechanisms that reflect heterogeneous operating characteristics. Conventional...

Resonance density range governs two-plasmon decay saturation and enables hot-electron prediction in inertial confinement fusion

The saturation level of parametric instabilities is critical in determining their impact on fusion plasmas. We identify the resonance density range of two-plasmon decay as the critical parameter governing nonlinear saturation of ion density fluctuations and Langmuir waves, which...

Fungal Phosphatase-Dependent Induction of Host Cell Pyroptosis by Candidalysin

Abstract Fungal infections pose a major public health threat and can cause host cell damage through diverse forms of regulated cell death. However, our understanding of how fungal pathogens interact with host to elicit pyroptosis remains in its infancy. Here, we show that candida...

Efficient complete coverage path planning for mining vehicles in complex environments via region decomposition and finite-state control

Complete coverage path planning for deep-sea mining vehicles is difficult because large mining areas require coordinated planning across multiple spatial scales, while dense and irregular obstacles can readily induce coverage deadlocks. This paper proposes a three-tier hierarchic...

The AcMYB15-AcWRKY24 module coordinates lignin and salicylic acid accumulation during kiwifruit resistance to bacterial canker.

Plants coordinate phenylpropanoid metabolism across different tissues to defend against pathogens, but the underlying transcriptional mechanisms remain unclear. Here, we identify the kiwifruit transcription factor AcMYB15 as a regulator that lignin deposition and salicylic acid (...

Dynamic and techno-economic assessment of solar-assisted biomass gasification for continuous hydrogen production

Solar-driven biomass gasification offers a promising route to produce green hydrogen while storing solar energy in chemical form. To mitigate solar intermittency, a solar/autothermal hybrid gasification strategy based on solar-input-dependent adjustment of gasifying-agent ratios...

A Radical Addition–Diradical Coupling Switch Unifies Cytochrome P450-Catalyzed Diketopiperazine Dimerization

Abstract Cytochrome P450 dimerases generate the remarkable structural diversity of dimeric diketopiperazine (DKP) natural products through highly selective intermolecular radical-mediated reactions. Although radical addition mechanisms have been established for most bacterial DKP...

Multimodal knowledge graph for Chinese architectural heritage based on semantic-geometric alignment

Traditional Chinese architectural heritage is documented through historical texts, field photographs and HBIM geometry, yet these sources are usually disconnected. This study proposes a multimodal knowledge graph framework that aligns textual semantics, visual evidence and 3D com...

NeuroChrono: Dissociated Neural Encoding with ChronoGate for Brain-to-Video Diffusion

Reconstructing natural video viewed by a subject from non-invasive neural recordings is a challenging problem at the intersection of computational neuroscience and generative modelling. Existing brain-to-video methods encode multi-modal neural signals (typically fMRI together wit...

Prognostic Value of Intraoperative Desmopressin Test for Long-Term Remission in Cushing's Disease: A Prospective Cohort Study

BACKGROUND AND OBJECTIVES: The desmopressin stimulation test is a cornerstone for the diagnosis of Cushing's disease (CD). Recent evidence suggests its potential for early recurrence prediction when performed postoperatively. However, its application as a real-time intraoperative...

ATAN: A hybrid graph neural network framework for accelerating aging-aware timing analysis

CMOS device aging critically challenges digital circuit design, where conventional timing analysis struggles with the large number of input conditions, standard cells, and process corners. This work proposes ATAN, a novel framework for accelerating aging-aware timing analysis, em...

Experimental investigation on a low dew point dehumidification system with temperature and pressure swing adsorption using desiccant coated heat exchanger

The supply of low-humidity dry air with a dew point below −30 °C mainly relies on desiccant wheels (DW) and adsorption towers (AT), while the high regeneration temperature and adsorption pressure result in substantial energy consumption. This study proposes a low dew point dehumi...

Multivalent antiviral conjugates enhance activity against Influenza via cross-linking viruses

Abstract Long-acting drug–Fc conjugate (CD388) has emerged as a new class of antivirals against influenza A and B, yet the mechanisms governing how Fc conjugation reshapes small-molecule function remain undefined. Here we establish a programmable multivalent antiviral conjugates...

Experimental and numerical investigation of LBE flow and heat transfer in a grid-spaced hexagonal 7-rod bundle with cosine axial power distribution

To support thermal-hydraulic design and safety assessment of lead-cooled fast reactor fuel assemblies, this study investigates the flow and heat transfer characteristics of lead-bismuth eutectic (LBE) in a grid-spaced hexagonal 7-rod bundle under a cosine axial power distribution...

TRIM3 functions as a tumor suppressor and predicts prognosis in triple-negative breast cancer: a multi-omics study with clinical cohort validation

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognosis and limited treatment options. Tripartite motif-containing protein 3 (TRIM3), an E3 ubiquitin ligase, has been implicated as a tumor suppressor in several cancers; however, its biologi...