Shanghai Jiao Tong University

Asymmetric Radical-Type Clayden Rearrangement for the Synthesis of Enantiopure 1,2-Aminothiols and 1,2-Aminoalcohols

Abstract We report herein an expedient method for the construction of enantiopure 1,2-aminothiols and 1,2-aminoalcohols starting from polar amino acids cysteine and serine via a photoredox-catalyzed, decarboxylation-enabled asymmetric radical-type Clayden rearrangement. The strat...

Deep potential-driven molecular dynamics unveiling composition–structure–property correlations in LiF–BeF2–UF4 molten salt system

Molten fluoride salts are critical heat carriers and fuel solvents for advanced molten salt reactors. Yet, their complex atomic interactions and composition-dependent structural evolution remain challenging to characterize over a wide range of temperatures and compositions. Here,...

Optimal Model Selection for Conformalized Robust Optimization

In decision-making under uncertainty, Contextual Robust Optimization (CRO) provides reliability by minimizing the worst-case decision loss over a prediction set. While recent advances use conformal prediction to construct prediction sets for machine learning models, the downstrea...

Formation control for multiple similar autonomous underwater vehicles with dynamic gaps via deep reinforcement learning

Dynamic gaps between simulation and real world environments are the major challenge for the implementation of deep reinforcement learning (RL) based formation control methods in systems composed of multiple similar autonomous underwater vehicles (AUVs), mainly involving hydrodyna...

Extrapolative Prediction of Propagation Rate Coefficient in Free-Radical Polymerization Based on kp (T, NI)-QSPR Model

This work assesses the extrapolation performance of the kp (T, NI)-QSPR model for free-radical polymerization. Although QSPR models often achieve high interpolation accuracy, their reliability for predicting beyond the training domain, a situation common in monomer reactivity exp...

Artificial intelligence in radiographic quantification and severity assessment of peri‐implant marginal bone loss: A systematic review

ABSTRACT Purpose To critically assess artificial intelligence (AI)‐based radiographic models for quantitative measurement, localization/detection, segmentation/keypoints, diagnostic classification, and severity or morphology assessment of peri‐implant marginal bone loss (MBL) and...

Development of an Olfactory Receptor (OR5K1)-Based Biosensor for Pyrazine Detection in Foods

Pyrazines are the key odorants in food contributing to baked and nutty aromas. In order to improve practicality, a novel electrochemical olfactory biosensor for pyrazine analysis was developed using an olfactory receptor (OR5K1) as the recognition element and AuNPs-PB/ZIF-8@SWCNT...

ProactiveAudioBench: Evaluating Condition-Driven Responses in Audio Streams

Audio assistants are moving from turn-based question answering toward continuous listening, where they must interpret incoming audio while deciding whether to respond or remain silent. Existing proactive benchmarks emphasize video and audiovisual interaction, while audio-centric...

Hermes \({}^{+}\) : Adaptive Memory-Efficient Pipeline Inference for Large Models on Edge Devices

The application of Transformer-based large models has achieved significant success in recent years. However, the exponential growth in the parameters of large models introduces formidable memory challenges for edge deployment. Prior works to address this challenge mainly focus on...

Parenting styles and fertility intention: Mediating effects of childbearing beliefs and psychological resilience

China's declining fertility rate is partly due to low fertility intention among childbearing population. To understand family influence on young people's fertility intention and its underlying mechanisms, this study examines how parenting styles (authoritarian vs. permissive) aff...

Efficient Removal of Cesium Ions from Radioactive Wastewater Using Na+-Intercalated Layered Manganese Oxide via Solid-Phase Synthesis

Abstract Efficient capture of radioactive cesium is critical for the long-term development and environmental protection of nuclear energy. This article reports the preparation of Na+-based cation-intercalated manganese oxide (CIMO) via a solid-phase reaction method and their appl...

Liquid–Metal-Induced Metal–Support Interactions for CO2 Hydrogenation

Abstract Metal–support interaction (MSI) is central to numerous industrial heterogeneous catalytic processes yet its classical realization typically requires high-temperature treatment (typically >500 °C), which often induces metal sintering and excessive encapsulation. Herein, w...

Non-apnea electrical impedance tomography for bedside ventilation–perfusion assessment during spontaneous breathing: a prospective cross-over validation study

Conventional saline-contrast electrical impedance tomography (EIT) perfusion imaging typically requires a brief end-expiratory apnea during saline injection to reduce respiratory interference. However, this maneuver is often difficult or impractical in spontaneously breathing pat...

Enhanced production of phomapyrrolidone a through culture-condition optimization and morphological regulation in Didymella sp. FATR0054

Phomapyrrolidone A (Ppd A) is a hirsutellone-type macrocyclic alkaloid derived from marine fungi, exhibiting significant activity against triple-negative breast cancer (TNBC). However, its low fermentation yield has limited further drug development. This study established a syste...

Population Pharmacokinetics of Topical Timolol Maleate Gel in Healthy Volunteers and Infants With Superficial Infantile Hemangioma

Although timolol ophthalmic solutions or hospital-compounded formulations have been used off-label for the treatment of superficial infantile hemangioma (IH), no topical timolol formulation has been developed specifically for this indication. This study was the first to develop a...

Experience-driven plasticity in the secondary somatosensory cortex in people born without hands

In congenital handlessness, where individuals rely on their feet for compensatory manual functions, reorganization in the primary somatosensory cortex (SI) appears to be limited to local shifts by adjacent body parts. It remains unclear how congenital handlessness and lifelong co...

Circumcision and continuous antibiotic prophylaxis in preventing recurrent febrile urinary tract infection in boys with high-grade vesicoureteral reflux

OBJECTIVE: To evaluate the effectiveness of circumcision and continuous antibiotic prophylaxis (CAP) in preventing febrile urinary tract infection (fUTI) in boys with high-grade primary vesicoureteral reflux (VUR). METHODS: This retrospective cohort included 114 boys younger than...

LAMAR-Bench: Evaluating Long-Form and Multi-Audio Understanding and Reasoning

Audio-language models increasingly process long recordings and multiple audio inputs, requiring fine-grained acoustic understanding, cross-audio reasoning, and decisions under goals and constraints. Existing benchmarks cover these requirements unevenly, while answer accuracy can...

Machine Learning-Guided Structural Optimization of High-Temperature Polybenzimidazole-Based Phosphonic Acid Proton Exchange Membranes

Abstract Polybenzimidazole-based phosphonic acid proton exchange membranes (PEMs) are promising candidates for high-temperature PEM applications. However, the enormous monomer design space and the sensitivity of proton transport to local chemical environments render the rational...

Ion Sensing in Concentrated Lithium-Ion Solutions by Oxide Solid Electrolytes and Activity-Coefficient Correction

Abstract The accurate detection of lithium ions (Li+) is crucial for therapeutic drug monitoring and lithium resource recovery and extraction, yet current electrochemical sensors based on polymeric membranes suffer from signal drift and short lifetimes in concentrated solutions....