Shanghai Jiao Tong University

Ultrasmall PolymericMicelles Enable Noninvasive TransdermalRosiglitazone Delivery via Lipid Fluidization and Transcytosis

Abstract Noninvasive transdermal drug delivery (TDD) offers sustained therapeutic release but is hindered by the stratum corneum (SC) barrier. Herein, we report ultrasmall polymeric micelles (PMs) embedded in poly(vinyl alcohol) hydrogels for the passive TDD of rosiglitazone (RGT...

Enhanced Sodium-IonTransport across Solid ElectrolyteInterphase via Electric-Field Modulation

Abstract The ion transport properties of the solid electrolyte interphase (SEI) critically govern the kinetics and cycling stability of rechargeable batteries. However, a mechanistic understanding of ion transport within this dynamic, multicomponent interphase remains limited. In...

LoRA Fine-Tuning Enables Controllable Mathematical Reasoning in Small Language Models: A Gating Pipeline on Qwen3.5-0.8B

We design a gating pipeline for LoRA fine-tuning of Qwen3.5-0.8B, a 24-layer hybrid of GatedDeltaNet and Full Attention, executed entirely on CPU. The pipeline runs three ablations: layer ablation selects full-module joint fine-tuning over single-module configurations; data curri...

Targeting the ANKRD54/ELOVL6 axis suppresses malignancy in BRAF mutant colorectal cancer by disrupting fatty acid metabolism and promoting ferroptosis

Abstract Background BRAF-mutant (BRAF-MT) colorectal cancer (CRC) represents a clinically aggressive subtype characterized by distinct biological features and significantly worse prognosis compared to BRAF wild-type (BRAF-WT) CRC, with median survival reduced by approximately 40%...

Noninvasive 3D mapping of tissue stress using reverberant shear wave

Abstract Mechanical stress is a fundamental aspect of soft tissues that influences cellular behavior and tissue integrity, yet noninvasive imaging of stress in vivo remains a major challenge. Conventional magnetic resonance elastography (MRE) measures tissue stiffness but not str...

MetabolicRNA Labeling: Adding a Temporal Dimensionto Transcriptomics and Epitranscriptomics Analysis

Abstract Transcriptomics and epitranscriptomics analyses have provided unprecedented insights into the transcriptome-wide RNA abundance and the post-transcriptional modifications of RNA across diverse biological processes. However, conventional transcriptomics and epitranscriptom...

Dehydration-induced CN- defects enable adaptive water regulation in Prussian blue cathodes for high-performance sodium-ion batteries

Abstract Prussian blue analogues have emerged as a promising cathode material owing to their open‑framework structure and high theoretical capacities; however, the presence and dynamic evolution of crystalline water severely constrain their electrochemical performance. Despite ex...

From policy intent to equitable reach: a qualitative study of the hybrid community-based rehabilitation service in China

Community-based rehabilitation (CBR) is promoted to improve rehabilitation access and social participation for persons with disabilities. In China, Self-Help and Peer Support for Persons with Disabilities (SHPSPD) service is the hybrid CBR service intended to complement clinical...

Vinylene‐Linked Covalent Organic Frameworks With Multi‐Intramolecular Coupling‐Promoted Photocatalytic CO 2 ‐to‐CO Conversion

ABSTRACT Covalent organic frameworks (COFs) offer significant potential for solar energy conversion, but their sluggish intrinsic charge‐transfer kinetics inherently restrict the activation of stable CO 2 . Herein, we developed a new electron‐deficient monomer 6,6′‐dimethyl‐3,3′‐...

Systematic pathway engineering of Escherichia coli for enhanced 3’-sialyllactose production

3’-Sialyllactose (3’-SL), the simplest sialylated human milk oligosaccharide (HMO), is widely incorporated into infant formula due to its roles in shaping the gut microbiota, inhibiting pathogen adhesion, and supporting neurodevelopment. In this study, we developed an efficient m...

Dynamic response characteristics of an entire long span submerged floating tunnel tube under wave and current loads

This study performs a numerical investigation of the dynamic response characteristics of a three-dimensional, full-scale submerged floating tunnel (SFT) tube using finite element software coupled with hydrodynamic analysis subroutines, under regular-wave and combined wave-current...

Discovery of TL10:A Soluble and Long-Acting MC4RAgonist with Tunable Lipidation for Sustained Pharmacological Activity

Abstract The development of long-acting MC4R peptide agonists remains challenging due to rapid clearance and structural sensitivity, where conventional permanent lipidation strategies often impair receptor engagement. Here, we report the discovery and characterization of TL10, a...

The obstacles and changes in Sino-European trade routes in the twenty-first century due to climate change and geopolitical risks

In the 21st century, global climate change and geopolitical risks are interconnected, presenting new challenges and influencing the trade dynamics between China and Europe. This paper investigates the effects of climate change and geopolitical risks on the trade route between Chi...

Exploring the hydrogen abstraction pathway in HOM formation from α -pinene photooxidation systems under varying NO conditions

Abstract. Highly oxygenated organic molecules (HOM) are formed via autoxidation during ⚫OH-initiated oxidation of α-pinene. We investigated the relative contributions of OH-addition and hydrogen (H)-abstraction to HOM formation from α-pinene photooxidation under varying nitrogen...

Technologies for Natural‐Synthetic Polymer Hybrids: Synergistic Biointerface Engineering From Fabrication to Devices

ABSTRACT This review summarizes natural and synthetic polymer hybrid materials for biointerface engineering. Natural polymers like chitosan, collagen, and hyaluronic acid (HA) provide biocompatibility and bioactivity but lack mechanical strength, whereas synthetic polymers such a...

A divided nation, divided views? How South Koreans’ political and social orientations shape their view of North Korea?

This study investigates how South Koreans’ political and social orientations shape their perceptions of North Korea and North Korean defectors. Analyzing nationally representative survey data (N = 8251) from the 2024 Social Integration Survey, we employ ordinary least squares reg...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

Macrophage-derived IL-1β drives endothelial-mesenchymal transition in diabetes mellitus erectile dysfunction

Diabetes mellitus erectile dysfunction (DMED) is frequently accompanied by corpus cavernosum (CC) fibrosis and endothelial dysfunction; however, the cellular drivers and molecular mechanisms underlying these pathological changes remain incompletely understood. Endothelial-to-mese...

Kinetic-Gated Signal Transduction Decouples Binding Affinity in a Dual-Pocket Riboswitch RNA

Abstract RNA has emerged beyond its traditional biological role to become a premier biorecognition element in biosensor design. While single-target RNA sensors demonstrate high specificity, multi-pocket variants, such as the tetrahydrofolate (THF) riboswitch, enable complex signa...

Deformable and transformable nitinol alloys enable enhanced strain hardening in aluminum

Secondary rigid fillers reinforce the metals, yet usually at the cost of strain localization and reduced plasticity/toughness. Nitinol (NiTi) alloy, as a representative of shape memory materials, exhibits reversible phase transformation ability and considerable deformability upon...