Shanghai Jiao Tong University

PET imaging enables direct evaluation of ferroptosis in HCC synergistically induced by anti-PD-L1 and Olaparib

Abstract The efficacy of PET image-guided immune checkpoint inhibitor-based therapy in hepatocellular carcinoma (HCC) management is limited by the lack of direct monitoring of therapeutic response. A key challenge is the mismatch between the therapeutic pathway and the imaging ta...

Structure-Acoustic Coupling Analysis of Underwater Acoustic Radiation Characteristics of a Multiple Intersecting Spherical Shell Under Acoustic Excitation

The underwater acoustic radiation of deepwater submersibles has become a growing concern in both academic and industrial communities. This study investigates the structure-acoustic coupling characteristics of a novel deepwater pressure hull, idealized as a triple spherical shell....

Interpretability-enhanced temporal surrogate modeling for wave-induced scour vulnerability assessment of vertical-wall structures

Scour compromises the stability and safety of vertical-wall structures, necessitating a systematic method to assess scour vulnerability. However, two key vulnerability elements remain unresolved, namely suitable grading thresholds and an efficient temporal scour surrogate model....

Lattice-Oxygen-Mediated Electronic Reconstruction of High-Entropy Oxides for Durable Fenton-like Water Treatment

Abstract High-entropy catalysts offer broad compositional tunability for peroxymonosulfate (PMS)-based water treatment, yet achieving rapid, selective, and durable oxidation remains challenging because metallic bonding in high-entropy alloys (HEAs) limits electronic communication...

A Novel Umami Peptide Selector (UPS) for Identifying Key Peptides from Maillard-Reacted Chicken Hydrolyzates: From Taste Evaluation to Antioxidant Properties

Abstract The Maillard reaction (MR) enhances the flavor of chicken enzymatic hydrolyzates, yet pinpointing key umami peptides remains challenging due to complex matrices. Sensory evaluation showed increased umami intensity despite decreased equivalent umami concentration (EUC: 0....

PCR: A Prefetch-Enhanced Cache Reuse System for Low-Latency RAG Serving

Retrieval-Augmented Generation (RAG) significantly improves Large Language Models (LLMs) but introduces massive input sequences that severely bottleneck the prefill stage. While KV-cache reuse reduces redundant computation for shared document prefixes, the reusable KV working set...

Automatic Generation of Inorganic Solid‐State Electrolytes via Unified Multi‐Modal Network

ABSTRACT Accurate prediction of ion transport properties remains a key bottleneck in computational discovery of solid‐state electrolytes, particularly because experimentally measured ionic conductivities are sparse and strongly dependent on crystal structure. Here we introduce US...

Clinical management of relapse in type 1 autoimmune pancreatitis: a systematic review and meta-analysis

Objectives: Type 1 autoimmune pancreatitis (AIP) has a high risk of relapse, but evidence to guide management is limited. We evaluated relapse patterns, predictors, and the comparative effectiveness of maintenance and relapse treatment. Methods: We systematically reviewed studies...

From nano-aggregates to macroscopic fibers: an integrated framework reconciling phase separation and laminar flow theories in high-moisture extrusion

High-moisture extrusion (HME) has emerged as a key technology for converting plant proteins into meat analogs with fibrous textures resembling animal muscle. Despite growing research interest, the multi-scale mechanisms governing fiber structure formation during HME remain incomp...

The Distinct Roles of Anger and Hope in PFAS Risk Processing: Integrating Mixed Emotional Appeals and Efficacy Information into the EPPM

ABSTRACT Guided by the Extended Parallel Process Model (EPPM), this study examines the distinct persuasive mechanisms of mixed emotional appeals and efficacy information in the context of environmental risk communication (per‐ and polyfluoroalkyl substances, PFAS). Results of a 3...

Optimal inertia allocation in networked DC microgrids with guaranteed steady-state and small-signal stability

DC microgrids (MGs) are considered an efficient solution for integrating distributed energy sources. In these networks during dynamic power imbalances, the stored energy in the capacitor of DC bus provides the natural tendency to resist voltage changes, equivalent to the physical...

Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice

Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both se...

A fractional integral ghost-structure method for a space-fractional anisotropic monodomain model in realistic bi-ventricular cardiac electrophysiology

This paper proposes a space-fractional anisotropic monodomain model for simulating action potential propagation in deforming cardiac tissue. The model incorporates an anisotropic conductivity tensor that depends on the local fiber orientation and evolves with tissue motion, there...

Antibody-Mimicking Nanocluster Ameliorates Osteoporosis in Preclinical Model

Abstract Osteoporosis occurs due to the synergistic effect of increased bone resorption and decreased bone formation. However, a therapeutic approach that can simultaneously inhibit osteoclastic resorption and promote osteogenic activity directly is still lacking. Growing evidenc...

A generalizable biopsychosocial risk score for stratifying disease vulnerability in healthy populations

Prospective risk stratification of future adverse health outcomes before clinical onset among ostensibly healthy individuals is an important goal of preventive and precision medicine, yet current tools remain largely disease-specific and do not provide an integrated measure of he...

Self-buoyant cell-spheroid culture programming multi-spheroid assembly

Tempo-spatially controlled culture and assembly of cellular spheroids are fundamental in engineering tissue-like assembloids for scalable application, yet remain a technical challenge. Here, we show self-buoyant culture of cell spheroids and programmable assembly of multi-spheroi...

Copper-based targeted nanozyme platform with sequential phototherapy-enzymatic therapy for orchestrating macrophage homeostasis in rheumatoid arthritis

Rheumatoid arthritis (RA) remains a formidable clinical challenge due to the vicious cycle of hyperactivated M1 macrophages, excessive reactive oxygen species (ROS), and sustained pro-inflammatory cytokine storm. Herein, we rationally engineered a targeted copper-based nanozyme p...

Vibration response of a waterjet propulsion pump under low-gas-fraction microbubble inflow

This study experimentally investigates the vibration attenuation effect of low-inlet-gas-volume-fraction microbubble inflow in a waterjet propulsion pump. Hydraulic performance and triaxial vibration responses at the inlet, impeller, and outlet were measured under IGVF values of...

Beyond Symbolism: Women’s Bodily Power and Religious Agency in Early Chinese Rainmaking Rituals

Rainmaking rituals constituted a vital part of ancient Chinese religious practice. They not only bore directly on the success or failure of agricultural production but also embodied the intricate i...

ENOPH1 orchestrates KRASG12D/G13D-driven glycolytic reprogramming and colorectal cancer progression through modulating the TGF-β/SMAD pathway

Oncogenic KRAS mutations (G12D/G13D) drive metabolic reprogramming in colorectal cancer (CRC), yet targetable downstream effectors remain poorly defined. Here, we identify enolase-phosphatase 1 (ENOPH1) as an essential transducer directly upregulated by the KRAS–MEK–ERK axis. ENO...