Sağlık Bilimleri Üniversitesi

AN OVERVIEW OF CURRENT RESEARCH ON THE DEVELOPMENT OF ANTHRAQUINONES AS ANTICANCER AGENTS

Objective: In this study, some scientific studies on anthraquinone compounds that have been synthesized in recent years and have been found to have high in vitro and in vivo anticancer activity are summarized. It is aimed to contribute to the design and development of new anthraq...

Legume Fodder in the Age of Climate Change: Resilience, Risks, and Revolutionary Solutions

Legume fodder crops are vital for sustainable agriculture and global food security because they fix nitrogen and enhance soil health. Legumes make up just 1.1% of the world's food supply, despite their many advantages. Cattle weight gain increases by 17% and milk output by 9.9% w...

Age-associated medialization of the cervical internal carotid artery: CT morphometric findings and an exploratory combined mucosa–midline grading framework

Purpose Cervical internal carotid artery (ICA) medialization may narrow anatomical safety margins during transoral and pharyngeal procedures. We quantified age-associated ICA morphometric changes on computed tomography (CT), assessed age-based discrimination for study-defined cri...

Clinical and Therapeutic Effects of Adjacent Organ Invasion in Gastrointestinal Stromal Tumor (GIST) Cases

Background: This retrospective study aimed to investigate the clinical and therapeutic effects of adjacent organ invasion in gastrointestinal stromal tumor (GIST) cases. Methods: The files of 114 GIST patients from various centers who underwent surgery by the principal investigat...

Biliary Duct Invasion in Colorectal Liver Metastases: Prevalence and Clinicopathologic Correlation in a Retrospective Cohort Study

Biliary duct invasion (BDI) is an underrecognized growth pattern of colorectal cancer (CRC) liver metastases that can mimic intrahepatic cholangiocarcinoma or intraductal papillary neoplasm of the bile duct. Its prevalence and clinicopathologic associations remain unclear. This s...

Investigation of functional independence and developmental areas in preschool children with quadriplegic cerebral palsy and cortical visual impairment

Cerebral palsy (CP) is a neurodevelopmental condition that affects areas of development and functional independence. Cortical Visual Impairment (CVI) is an important problem frequently observed in children with CP. This study was planned to compare the functional independence and...

K-wire Versus Plate–Screw Fixation in Fifth Metacarpal Neck Fractures: Functional Outcomes and Treatment Cost

Background: Fifth metacarpal neck fractures are common hand injuries, and various surgical techniques have been described for their management. However, the comparative effectiveness and cost implications of these techniques remain controversial.Methods: This retrospective study...

Disparities in Psychiatric Background and Service Utilization: A Comparative Study of Rural and Urban Health Board Applicants in Child and Adolescent Psychiatry

Background: Regional disparities between rural and urban environments significantly impact access to pediatric mental health services. While environmental factors influence childhood psychological well-being, the gap in service utilization and clinical characteristics between the...

Development of a Plant Bioactive-Rich Tahini-Based Powder Enriched with Pea Protein and Coconut Milk Powder: Antioxidant Properties, Nutritional Characterization, In Vitro INFOGEST Static Digestion

This study aimed to develop a spray-dried tahini-based powder enriched with pea protein and coconut milk powder and to comprehensively characterize its plant bioactive composition, antioxidant potential, nutritional properties, and bioaccessibility following the standardized INFO...

FOLFOX Plus Bevacizumab Rechallenge Versus Regorafenib as Third-Line Treatment in Metastatic Colorectal Cancer: The Role of the Oxaliplatin-Free Interval

Background: The optimal use of chemotherapy rechallenge in later-line metastatic colorectal cancer (mCRC) remains uncertain. We compared third-line FOLFOX plus bevacizumab rechallenge with regorafenib and examined whether the oxaliplatin-free interval was associated with treatmen...

Emerging cfDNA technologies in glioblastoma through fragmentomics and sonobiopsy

Glioblastoma (GBM) is difficult to monitor using liquid biopsy because the tumor-derived fraction of circulating cell-free DNA (cfDNA), i.e., circulating tumor DNA (ctDNA), is often very low in plasma and because spatial and temporal heterogeneity complicate single-variant tracki...

Optimizing In Vitro Organogenesis in Sunflower (Helianthus annuus L.) Using Cotyledon and Root Node Explants

Sunflower (Helianthus annuus L.) is widely recognized as a recalcitrant species in tissue culture, which severely restricts its micropropagation and genetic transformation efficiency. To address this limitation, this study establishes a novel, highly efficient, and reproducible i...

Adenomyosis and Uterine Fibroids: Two Distinct Yet Overlapping Clinical Entities

Adenomyosis and uterine fibroids are among the most common benign uterine disorders in women of reproductive age and represent major causes of abnormal uterine bleeding, pelvic pain, and infertility. Despite their distinct histopathological features, they frequently coexist and s...

Green-Synthesized Mesoporous Silica-Enhanced Herbal Nanofibers with Antimicrobial, Anti-Inflammatory, and Biocompatible Wound Healing Potential

Advanced wound dressings should actively promote tissue repair while preventing microbial infection and excessive inflammation. In this study, multifunctional electrospun nanofibers composed of poly(vinyl alcohol)/chitosan/gelatin were developed by incorporating green-synthesized...

Comparing clinicopathological factors and quantitative background parenchymal enhancement to predict pathological complete response after neoadjuvant chemotherapy in breast cancer

PURPOSE: To investigate the predictive value of deep learning (nnU-Net)-based fully automated quantitative background parenchymal enhancement (BPE) metrics and clinicopathological factors for pathological complete response (pCR) in patients with breast cancer receiving neoadjuvan...

Engineering Red Blood Cell Membrane-Coated PLGA Nanoparticles for Kahweol Delivery: Formulation Development and Pharmacokinetic Assessment

Kahweol is an active diterpene with anti-inflammatory, antioxidant, and anticancer properties; however, its use may be limited by unfavorable pharmacokinetic characteristics. This study aimed to develop kahweol-loaded poly(lactic-co-glycolic acid) (PLGA) and red blood cell membra...

ROMATOİD ARTRİT TEDAVİSİNDE NANOTEKNOLOJİ DESTEKLİ İLAÇ VERİLİŞİ

Amaç: Romatoid artrit (RA), dünya nüfusunun yaklaşık %1’ini etkileyen kronik otoimmun bir hastalıktır. Kemik ve kıkırdakta bozulma, ağrı, vücudun birçok bölgesinde enflamasyonla karakterize bir hastalık olup ilerleyen süreçte ölümle de sonuçlanabilmektedir. Patogenezi tam olarak...

MATRIX METALLOPROTEINASE INHIBITORS WITH ANTICANCER ACTIVITY

Objective: To provide up-to-date information on the structure, function, and specific activities of matrix metalloproteinases (MMPs), with particular emphasis on gelatinases MMP-2 and MMP-9 as anticancer therapeutic targets due to their roles in cancer development, angiogenesis,...

Arthroscopic Free Bone Block Transfer Technique Using Iliac Crest Autograft With Anchor‐Button Fixation for Glenohumeral Instability and Glenoid Bone Loss

Abstract Bone block transfer for the treatment of glenohumeral instability with severe glenoid bone loss or multiple recurrences has grown in popularity in recent years. In this technical note, we described an arthroscopic‐assisted free bone block transfer technique, using a spec...

Reliability and validity of the Turkish EQ-5D-5L in adults living with HIV

Background The advent of antiretroviral therapy (ART) has shifted human immunodeficiency virus (HIV) care from survival toward optimizing quality of life. In the contemporary ART era, health-related quality of life (HRQoL) is recognized as a core outcome in HIV care. The EQ-5D-5L...