Sağlık Bilimleri Üniversitesi

Association of Baseline Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios with Relapse in Sarcoidosis: A Single Center Retrospective Study

Background: Sarcoidosis is a heterogeneous multisystem granulomatous disease characterized by variable clinical course and relapse potential. Current ATS, BTS, and ERS guidance highlights the need for accessible biomarkers that may support clinical assessment and longitudinal fol...

Pediatric DOCK8 Deficiency Beyond Infections and Atopy: An Immunoactinopathy with Immune Dysregulation and Multisystem Involvement

Background/Objectives: Dedicator of cytokinesis 8 (DOCK8) deficiency is an autosomal recessive combined immunodeficiency and an actin cytoskeleton-related inborn error of immunity characterized by severe atopy, recurrent infections, and broad immune dysregulation. We aimed to des...

Water Dissociation on Molybdenum and Tungsten Oxide Trimers: Roles of Oxidation State, Structure, and Microsolvation

Abstract Here we present results of a density functional theory based systematic investigation of water adsorption and dissociation on Mo3O9/Mo3O8 and W3O9/W3O8 clusters. For fully oxidized Mo3O9 and W3O9, adsorption of a single water molecule is strongly exothermic (−0.81 and −0...

Therapeutic Effects of Ganoderma lucidum Against Aβ-Induced Neurotoxicity in SH-SY5Y Cells: In Vitro Evidence and Computational Validation of Human Protein Targets

The triterpenoid and polysaccharide constituents of Ganoderma lucidum (GL) are believed to influence key pathogenic pathways in Alzheimer’s disease (AD). This study first examined the molecular rationale for GL’s neuroprotective properties by subjecting its principal triterpenoid...

Association between B-type natriuretic peptide levels and NYHA functional class in older home-care patients with atherosclerotic heart disease: a cross-sectional study

Atherosclerotic heart disease (AHD) is a major contributor to cardiovascular morbidity and may lead to subclinical myocardial dysfunction and eventual heart failure (HF), particularly in elderly populations. B-type natriuretic peptide (BNP) and New York Heart Association (NYHA) f...

Evaluation of Dermatologists’ Opinions in the Face of Increasing Scabies Cases: A Survey Study

Objective: Scabies is a common and highly contagious parasitic skin disease that continues to pose a significant public health burden worldwide and in Türkiye. This study aimed to evaluate the approaches, experiences, and challenges of dermatologists in Türkiye regarding the diag...

The “Lock‐and‐Key” Advantage: Molecularly Imprinted Polymers in Modern Electrophoresis in Drug Assay

Molecularly imprinted polymers (MIPs) have gained increasing attention as synthetic recognition materials that mimic biological binding sites while offering greater stability and lower cost. In recent years, their combination with electrophoretic techniques has opened new possibi...

Posterior mediastinal unicentric Castleman disease treated by video-assisted thoracoscopic surgery

Castleman disease (CD) represents an uncommon lymphoproliferative condition that can manifest as a mediastinal mass and resemble other thoracic pathologies. Establishing a definitive diagnosis before surgery is often difficult, making histopathological analysis crucial. We presen...

Septal Perforation Repair Improves Olfaction and Mucociliary Clearance: A Prospective Study

OBJECTIVE: Nasal septal perforation (NSP) disrupts normal nasal physiology and may lead to significant functional symptoms. This study aimed to prospectively evaluate changes in olfactory function, nasal mucociliary clearance (MCC), and quality of life (QOL) following septal perf...

Clinical Impact of Fingolimod-Associated Lymphopenia in Multiple Sclerosis: A Real-World Cohort Study

Background and Objectives: Fingolimod, a sphingosine-1-phosphate receptor modulator, is an effective disease-modifying therapy for relapsing forms of multiple sclerosis (MS). Although lymphopenia is a well-recognized pharmacological effect, its clinical significance remains uncer...

Meteorological factors and daily afebrile seizure counts in children: a time-series analysis

Abstract Background The relationship between meteorological factors and seizure occurrence remains controversial, particularly in pediatric populations where data are limited and may be confounded by febrile seizures. This study aimed to investigate the association between daily...

Prognostic value of the preoperative HALP score for 30-day and 1-year mortality in older adults undergoing hemiarthroplasty for intracapsular hip fracture: a retrospective cohort study

Hip fracture mortality in older adults reflects biological reserve as well as the acute injury. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score integrates anemia, nutritional status, immune competence, and systemic inflammatory burden. We evaluated whether preopera...

Etiology and Outcomes of Hypernatremia in a Tertiary Pediatric Intensive Care Unit: The Role of Disease Severity

Purpose: Hypernatremia is a common electrolyte disorder in pediatric intensive care units (PICU) and is associated with considerable morbidity and mortality. We aimed to evaluate underlying etiologies, clinical characteristics, and factors associated with outcomes in critically i...

Large Language Models in Perioperative Antithrombotic Management: A Blinded Scenario-Based Expert Evaluation

Background: Perioperative antithrombotic management is a complex and high-risk aspect of anesthesia practice, requiring a careful balance between bleeding and thromboembolic risks. Large language models (LLMs) are increasingly explored for clinical decision support, but their rel...

Development and effectiveness of a user-centered mobile application for informal caregivers of people living with dementia: randomized controlled trial

Abstract Background Dementia places substantial physical, psychological, and social demands on informal caregivers, and caregiving needs may change across the dementia trajectory as cognitive, behavioral, and functional changes alter day-to-day care demands. Digital interventions...

Maternal and neonatal outcomes following cesarean myomectomy: a comparison between fibroid-associated and fibroid-free cesarean deliveries

Objective: To compare maternal and neonatal outcomes among women undergoing cesarean section (CS) with concomitant myomectomy, women with uterine fibroids managed conservatively at cesarean delivery, and women without uterine fibroids. Material and Methods: This retrospective coh...

Performance of large language models and pediatricians in complex pediatric scenarios: a prospective, randomized comparative study of clinical task accuracy and decision support

To compare response accuracy between contemporary large language models (LLMs) and pediatricians across difficulty-stratified pediatric clinical vignettes, characterize LLM response times, and quantify the effect of AI-generated outputs on pediatrician decisions. In a prospective...

External Validation of Clinical Risk Scores and Machine Learning Models for Predicting 30-Day Cardiovascular Risk After Noncardiac Surgery: The PERICARE Study

Background: Machine learning (ML) has emerged as a promising approach for preoperative cardiovascular risk prediction; however, the generalizability of ML models across institutions remains uncertain. Moreover, comprehensive head-to-head comparisons between ML algorithms and esta...

Effective Protection Against Alcohol-Related Cardiac Damage: Dapagliflozin

Chronic alcohol consumption causes serious damage to the liver and cardiovascular system and leads to neoplastic lesions in various organs such as the esophagus, liver, and breast. In our study, we evaluated the protective effects of standard and high doses of dapagliflozin again...

Comparison of the Effects of Kinesio Taping and Foam Roller Exercises in Individuals with Non-Specific Chronic Low Back Pain

Background/Objectives: Non-specific chronic low back pain is a prevalent musculoskeletal disorder that impairs flexibility, sleep quality, functional capacity, and quality of life. Conservative treatments such as Kinesio taping and foam roller exercises are widely used, yet compa...