Sağlık Bilimleri Üniversitesi

Effects of vasopressor dose on microcirculation despite preserved macrohemodynamic targets in septic shock: a prospective observational study

Background Septic shock may be complicated by hemodynamic incoherence, in which macrohemodynamic targets are achieved despite persistent microcirculatory alterations. Whether norepinephrine requirement is associated with dynamic microvascular reactivity after initial resuscitatio...

Longitudinal Assessment of Diastolic Function and Myocardial Strain in Type 2 Diabetes: A Comparison of Empagliflozin and Linagliptin

OBJECTIVE: The cardiovascular effects of sodium-glucose cotransporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors have attracted increasing interest in patients with type 2 diabetes mellitus. This study aimed to compare the time-dependent effects of empagliflozin and linag...

A simple clinical–laboratory risk score for preoperative identification of ovarian torsion: a retrospective diagnostic study

Timely diagnosis of ovarian torsion remains challenging due to nonspecific clinical presentation and limitations of imaging. Delayed recognition may result in ovarian loss. Simple, readily available tools to support early risk stratification are therefore needed. In this retrospe...

Mid-Term Outcomes of the Ozaki Procedure: A Single-Center Experience

BACKGROUND: To assess the midterm clinical and echocardiographic outcomes of the Ozaki (aortic valve neocuspidization (AVNeo)) procedure performed at a single center. METHODS: A total of 258 patients who underwent the AVNeo procedure between February 2019 and February 2025 were r...

Comparative Efficacy of Knee-High Versus Thigh- High Compression Stockings in Managing Chronic Venous Insufficiency: A Retrospective Comparative Cohort Study

ObjectiveTo compare the clinical efficacy and patient adherenceof knee-high versus thigh-high compression stockings,each combined with calcium dobesilate, versus pharmacologictherapy alone in the conservative managementof chronic venous insufficiency (CVI).Material and MethodThis...

Effectiveness of vestibular electrical stimulation combined with vestibular rehabilitation in chronic unilateral vestibular hypofunction: A randomized controlled trial

Objectives: To evaluate the effectiveness of vestibular electrical stimulation (VES) combined with vestibular rehabilitation (VR) in patients with chronic unilateral vestibular hypofunction (UVH). Patients and Methods: Forty patients aged 18-65 years, diagnosed with UVH, were ran...

Evaluation of the pSOFA Score in a Pediatric Intensive Care Unit and Its Discriminative Performance Compared with PRISM 4 and PIM 3

Objectives: We aimed to evaluate the performance of the age-adapted Pediatric Sequential Organ Failure Assessment (pSOFA) score, as a predictor of mortality in patients admitted to pediatric intensive care units (PICUs), and to compare it with the Pediatric Risk of Mortality 4 (P...

Technique-stratified reintervention outcomes after surgical reconstruction for nutcracker syndrome: a single-center retrospective study

Nutcracker syndrome (NCS) is an uncommon venous compression disorder resulting from extrinsic compression of the left renal vein (LRV), either between the superior mesenteric artery (SMA) and the aorta (anterior NCS) or between the aorta and the vertebral body (posterior NCS). Ow...

Incremental Anatomical Value of CT Angiography Beyond Echocardiography in the Preoperative Assessment of Pediatric Conotruncal Anomalies: A Surgical Correlation Study

Background: Conotruncal anomalies frequently involve extracardiac vascular structures that are critical for surgical planning yet incompletely assessed by transthoracic echocardiography (TTE). We evaluated the incremental diagnostic value of CT angiography (CTA) beyond TTE using...

Clinical Outcomes in Initial Hirudotherapy versus Standard Treatment in Idiopathic Granulomatous Mastitis: A Comparative Cohort Study

Objective: Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory disease characterized by a high risk of recurrence and fistula formation. Spontaneous remission has been reported in up to 50% of cases, particularly in mild forms, within 6-24 months without interventio...

Depression, anxiety and stress symptoms in women with polycystic ovary syndrome with and without fertility treatment and in non-PCOS controls: a cross-sectional comparative study

Abstract Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder of reproductive-aged women that has been linked to psychological difficulties such as depressive and anxiety symptoms. We compared Depression Anxiety Stress Scale-21 (DASS-21) scores between women...

Preoxygenation with deep breathing plus pressure support and positive end-expiratory pressure in obese patients and ultrasound assessment of gastric distension: a randomized controlled trial

Abstract Background It is known that anatomical and physiological differences in obese patients make preoxygenation difficult and limit its success. This study aimed to investigate the effects of adding pressure support ventilation (PSV) and positive end expiratory pressure (PEEP...

The Relationship Between the Remnant Cholesterol Inflammation Index and Coronary Collateral Circulation in Patients with Chronic Total Occlusion

Background and Objectives: Although chronic total occlusion (CTO) often presents with varying degrees of coronary collateral circulation (CCC), the biological factors accompanying inadequate collateralization are not fully established. The Remnant Cholesterol Inflammation Index (...

Machine Learning and MILP for Capacity Optimization and Educational Workload in Academic Endodontics

ABSTRACT Objectives Appointment scheduling in endodontic clinics is challenging due to heterogeneous treatment durations and varying practitioner competencies. Conventional scheduling methods frequently overlook these complexities, leading to underutilized unit capacity, extended...

Prognostic markers in pulmonary embolism: from risk scores to clinical outcomes

Abstract Background Pulmonary embolism (PE) is a potentially fatal cardiopulmonary emergency with unpredictable outcomes. Accurate risk stratification is critical for guiding intensive care unit (ICU) admission, optimizing resources, and improving prognosis. Clinical scores such...

Diagnostic concordance of remote WSI-based thyroid cytology compared to conventional cytological diagnosis: a pilot study

Abstract Background Whole slide imaging (WSI) has emerged as a key component of digital pathology, enabling remote diagnostics and standardized evaluation. However, its diagnostic concordance in thyroid cytopathology, particularly under real-world conditions, remains insufficient...

Severity-Dependent Modulation of Visual Attention Under Fatigue During Bitewing Radiograph Inspection: A Perceptual Eye-Tracking Experiment

Purpose: To examine whether visual fatigue following a full clinical day differentially affects visual attention to approximal carious lesions of varying severity on bitewing radiographs using eye-tracking methodology.Methods: In this two-group experimental eye-tracking study, 60...

Muscle Dysmorphia and the Use of Nutritional Ergogenic Supplements Among Amateur Male Bodybuilders: A Cross‐Sectional Study

BACKGROUND: This study aimed to evaluate the levels of muscle appearance satisfaction and ergogenic aid use among adult male amateur bodybuilders. METHODS: In this descriptive cross-sectional study, a questionnaire containing demographic information, the "Nutrition Ergogenic Supp...

Intraocular Mitomycin-C in the Management of Recurrent Retinal Detachment and Proliferative Vitreoretinopathy: A Comparative Study With a Control Group

PURPOSE: This study aimed to evaluate the impact of intraoperative mitomycin-C (MMC) application during pars plana vitrectomy (PPV) on anatomical success, the need for additional surgery, and visual outcomes in patients with recurrent rhegmatogenous retinal detachment (RRD) assoc...

The Frontal QRS-T Angle and Cardiovascular Disease: A Narrative Review of Electrophysiological Basis, Measurement, and Clinical Utility

The QRS-T angle quantifies the divergence between the vectors of ventricular depolarization and repolarization and is regarded as a surrogate for global heterogeneity of ventricular repolarization. Its frontal-plane variant, calculated as the absolute difference between the autom...