Sağlık Bilimleri Üniversitesi

In vitro inhibition effect of sulphonylhydrazones against Malassezia furfur

Purpose: In this study, the in-vitro antifungal activity of previously synthesized compounds, including methanesulfonic acid hydrazide (I) and its derivatives 3.5-ditertbutylsalicylaldehyde methanesulfonylhydrazone (II), 3-tertbutylsalicylaldehyde methanesulfonylhydrazone (III),...

Functional Outcomes of Wedge Plate Versus Dynamic Hip Screw Applications in Adult Femoral Trochanteric Fractures: A Retrospective Review

Objective: To retrospectively compare the clinical and functional outcomes of wedge plate and dynamic hip screw (DHS) fixation in adult patients with trochanteric femoral fractures.Methods: This retrospective comparative analysis included 64 hips in 63 patients aged 18-60 years w...

Comparison of patient preference for and interpretability of video-based pain-expression scenarios and the numerical rating scale for postoperative pain assessment: a prospective observational study

Background: Postoperative pain assessment relies primarily on numeric self-report tools, such as the numerical rating scale (NRS); these tools require abstract numerical cognition and may be challenging for some patients in the immediate postoperative period. Thus, in this prospe...

Beyond Screening Populations: Context-Dependent Performance of Lung Cancer Risk Assessment Strategies in a Diagnostically Enriched Cohort

Background/Objectives: Lung cancer screening with low-dose computed tomography has been shown to reduce disease-specific mortality, but optimal strategies for identifying high-risk individuals remain debated. This retrospective, single-center cohort study examined the context-dep...

Understanding Cognitive Heterogeneity in Children Referred to Mental Health Services: Evidence from a Large Clinical Sample

Background: General ability and verbal–performance organisation are established features of Wechsler batteries, while the diagnostic value of subtest profile types remains contested. We examined whether ten WISC-R subtests in a large clinical referral sample contained reproducibl...

Metabolic pathways are associated with increased estimated cardiovascular risk in major depressive disorder: a QRISK3-based analysis

Background Depression and anxiety are among the most commonly encountered disorders in psychiatric practice. Previous studies have shown that both cardiovascular disease and cardiovascular risk are increased in these disorders. This study aimed to investigate the potential relati...

Changes in Symptoms and Lung Function During Three Months of Individually Tailored Inhaled Therapy in Chronic Obstructive Pulmonary Disease: A Prospective Observational Cohort Study

Background. Randomised controlled trials have established what individual inhaled regimens can achieve in chronic obstructive pulmonary disease (COPD) under controlled conditions, but they recruit selected populations and enforce protocol-driven follow-up. How patients fare on re...

Are arterial and venous procedure-related thromboses the same disease? a clinical and hematological comparative study

Arterial and venous thrombosis are traditionally regarded as pathophysiologically distinct processes, yet procedure-related thrombosis following vascular access offers a controlled setting in which an identical iatrogenic trigger (endothelial injury) precipitates thrombosis in di...

Fibrinogen-to-Albumin, Platelet-to-Albumin, and Creatinine-to-Albumin Ratios in the Assessment of Preeclampsia Severity: A Retrospective Case–Control Study

Background: Preeclampsia (PE) is a multisystem pregnancy disorder associated with endothelial dysfunction, inflammation, and coagulation abnormalities. This study evaluated the fibrinogen-to-albumin ratio (FAR), platelet-to-albumin ratio (PAR), and creatinine-to-albumin ratio (Cr...

Effect of iTBS and rTMS Combined with Robotic Rehabilitation on Ambulation and Lower Extremity Motor Function in Chronic SCI Patients

Objective: To investigate the effectiveness of intermittent theta-burst stimulation (iTBS) and repetitive transcranial magnetic stimulation (rTMS) combined with robotic rehabilitation on ambulation and lower-extremity motor function in patients with spinal cord injury (SCI). Desi...

Urethral Stricture with a Miniaturised (22 Fr) Versus Standard (26 Fr) Resectoscope Sheath During Thulium Fibre Laser Enucleation of the Prostate: A Prospective, Two-Centre Comparative Cohort Study

Objectives: We aimed to compare the observed rates of postoperative urethral stricture between patients undergoing thulium fibre laser enucleation of the prostate (ThuFLEP) using a 22 Fr miniaturised instrument strategy and those treated using a standard 26 Fr strategy. Methods:...

SOFA-2 vs. SOFA and early warning scores for short-term mortality in older adults with sepsis in the emergency department

SOFA-2 was developed to update the SOFA score for contemporary clinical practice, but its performance in older adult emergency department (ED) patients with sepsis is uncertain. We evaluated SOFA-2 for short-term mortality prediction and compared it with SOFA and commonly used ea...

Childhood maltreatment and risky behaviors in Syrian refugee and host-country adolescents: a cross-sectional multi-group structural equation modeling analysis

Syrian refugee and Turkish host-country adolescents may experience distinct patterns of adversity, stress, and behavioral risk; however, the psychosocial processes linking childhood maltreatment to adolescent risky behaviors across these populations remain insufficiently understo...

A Compact Unified Model for Moderate-to-Severe Carotid Artery Stenosis Using Image Segmentation: A Multicenter Study.

BACKGROUND: This study aimed to evaluate the diagnostic performance of a new artificial intelligence model, the compact unified model (CU-Model), for moderate-to-severe carotid artery stenosis using digital subtraction angiography (DSA) images compared to clinical reference stand...

Limited Incremental Value of Six Haemogram-Derived Inflammatory Indices for Detecting Endometrial Carcinoma and Intraepithelial Neoplasia in Abnormal Uterine Bleeding: A Case–Control Study

Background/Objectives: Haemogram-derived inflammatory indices are proposed as inexpensive markers of endometrial neoplasia, but almost all supporting evidence is prognostic, from women already known to have carcinoma. We compared six indices head-to-head and asked whether any imp...

Guideline-grounded retrieval versus unconfigured generation in obstructive sleep apnea: a pilot comparison of notebookLM and ChatGPT for AASM v3.0 PSG scoring-rule questions

Large language models (LLMs) are increasingly used in sleep medicine, but their reliability for polysomnography (PSG) scoring-rule tasks that require up-to-date guideline knowledge remains uncertain. This pilot study compared response quality when identical AASM v3.0 PSG scoring-...

Cross-cultural adaptation and reliability, agreement, and construct validity of the Turkish neck disability 10 in patients with neck pain

PURPOSE: To cross-culturally adapt the Neck Disability 10 (ND10) into Turkish and evaluate its measurement properties in adults with neck pain and related disorders. MATERIALS AND METHODS: Following forward-backward translation, expert committee review, and cognitive debriefing,...

Serial postoperative lactate levels and in-hospital mortality in surgically managed acute mesenteric ischemia: a retrospective cohort study

Acute mesenteric ischemia (AMI) is a life-threatening abdominal emergency with persistently high mortality. Although lactate is widely used as a marker of tissue hypoperfusion, most previous studies have focused on preoperative measurements. This study evaluated the association b...

Investigation of mandibular cortical and trabecular bone in secondary polycythemia: case-control study

This study aimed to assess differences in mandibular cortical index (MCI) scores and fractal dimension (FD) values of mandibular trabecular bone between patients with secondary polycythemia and healthy controls using panoramic radiographs. A retrospective study was conducted with...

Patient-reported outcomes after revision to the Rigicon® Infla10 inflatable penile prosthesis: a multicentre retrospective registry cohort with a cross-sectional telephone survey

Revision of an inflatable penile prosthesis (IPP) is technically more demanding than primary implantation and usually requires complete IPP removal and replacement. In selected revision cases, patient expectations or surgeon preference may lead to substitution with an IPP from a...