Purdue University West Lafayette

Coating development for fuel claddings in advanced nuclear reactors

Coating development for fuel claddings in advanced nuclear reactors A recap of a 20-year journey in the exploration of coating applications for advanced nuclear reactors. Thin films and coatings are a thin layer of materials coated on a surface to serve certain functions that are...

Signal-integrated control of immune and reparative programs establishes blood-derived fibrocytes reprogrammable toward induced pluripotency

Fibrocytes represent a distinct somatic cell type derived from peripheral blood leukocytes, first described as spindle-shaped adherent cells with dual hematopoietic and mesenchymal features. Although fibrocytes were identified in early descriptive studies across several mammalian...

From Trees to Treewidth: Inventory Management in Complex Supply Chain Networks

We propose an exact linear programming (LP)-based solution approach to the Guaranteed Service Model (GSM), one of the most widely applied models for optimizing safety stock placement in supply chain networks. Our approach handles any directed acyclic network and any cost function...

Tideglusib as a First-in-Class Chemical Probe for NatA: Identification, Mechanism, and Cellular Validation of an Allosteric, CoA-Dependent Inhibitor

N-terminal acetyltransferase A (NatA) catalyzes 40-57% of eukaryotic Nα-acetylation, a co-translational modification critical for protein stability, localization, and function, yet no validated small-molecule probe of NatA has been reported. Here, we describe the discovery and ch...

Positive allosteric modulator of SERCA pump NDC-1171 attenuates cardiac functional decline in mouse model of Duchenne muscular dystrophy

Abstract Progressive cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Dysregulation of calcium handling has been implicated in cardiomyopathy progression in DMD. Here we describe a therapeutic approach to improve calcium homeostasis in a mouse mo...

Identifying Co‐Expressed lncRNAs Correlated With Traits of Interest in an Animal Model for Metabolic Diseases in Humans

Nutrigenomics investigates how nutrients modulate gene expression. Among them, fatty acids (FA) play important roles in regulating gene transcription, while long non-coding RNAs (lncRNAs) may be associated with gene regulation and metabolic diseases. This study aimed to analyze t...

Normal approximation for subgraph counts in age-dependent random connection models

Abstract We study normal approximation of subgraph counts in a model of spatial scale-free random networks known as the age-dependent random connection model . In the light-tailed regime where only moments of order left parenthesis 2 plus epsilon right parenthesis ( 2 + ε ) $(2+\...

Integrated Time–Cost–Risk Management in Industrial Construction: A Systematic Review and Unified Analytical Taxonomy

Industrial construction projects involve complex interactions among uncertainty, risk, schedule, and cost, motivating the development of advanced analytical and decision-support methodologies. This study systematically reviews methodological approaches to risk assessment and perf...

Side-Chain Grafting Frequency Controls Trap Formation and Polaron Mobility in Organic Mixed Conductors

Abstract Organic mixed ionic–electronic conductors (OMIECs) are π-conjugated polymer–electrolyte composites that support coupled ionic and electronic transport, making them candidates for bioelectronics, electrochemical sensors, and energy storage devices. Despite growing interes...

Digital Financial Inclusion and Agricultural New Quality Productive Forces: Evidence from China

Agricultural new quality productive forces (ANQP) provide an important foundation for high-quality agricultural development and sustainable rural transformation. Using panel data for 30 Chinese provinces from 2011 to 2022, this study examines the effect of digital financial inclu...

Identifying Informative Psychophysiological and Gaze-Based Indicators for Inferring Human Cognition During Automated Driving: An Information-Theoretic Approach

We present an information-theoretic framework for identifying which physiological and eye-gaze-based indicators, and at what temporal scales, are most informative of cognition-related reliance behavior during conditionally automated (SAE Level 3) driving. We analyze data collecte...

Aging beyond older adults: Transdisciplinary perspectives on demographic change in Japan

Population aging is increasingly recognized not merely as a demographic phenomenon, but as a broader societal transformation reshaping care systems, labor structures, infrastructure, communication, governance, and everyday social relations. Using Japan as an example of an advance...

Disentangling neural and physiological contributions to fNIRS signals during active and passive auditory tasks

Functional near-infrared spectroscopy (fNIRS) is increasingly used to study speech processing because it balances spatial and temporal resolution, but fNIRS signals are susceptible to physiological interference, particularly during active-response tasks. This study examined how s...

Reformulating Time-Cure Superposition to Describe the Phase Transition in Rearranging Gel Networks

Abstract Rearranging hydrogels are used for applications that require tailored control of solid- and liquid-like properties. These applications necessitate pinpointing the phase transition, where a sample-spanning structure is formed or broken. To characterize the mechanical prop...

A Conceptual Framework for Coordination in Human-Automated Vehicle (AV) Teaming: Structural Dimensions and Implications

Human-automated vehicle (AV) interaction can be understood as a form of teaming because safe driving often depends on coordinated contributions from both the driver and automation. Although AVs are often framed as reducing human involvement, many dynamic scenarios still require d...

Smart fertigation: Automated fertilizer application based on plant growth using digital sensors with IoT capability

Liquid organic fertilizers (LOF) are used to supply additional nutrients to crops. However, LOF are expensive to use regularly. In this research, a smart fertigation treatment (S), where LOF was applied based on lettuce plant growth, was compared to a manual treatment (M) in a gr...

A Review on Lymphatic Uptake of Large Therapeutic Proteins after Subcutaneous Injection

Subcutaneous (SC) administration has emerged as a promising route for delivering large therapeutic proteins, offering advantages such as improved patient convenience and reduced healthcare costs. However, the mechanisms that regulate the uptake of these macromolecules are not yet...

Beyond Transparency: Reframing Ethical Explainability in Human–AI Teams

Purpose: Explainable artificial intelligence (XAI) is increasingly promoted as a mechanism for improving transparency, trust, and accountability in AI-assisted decision-making. However, its ethical value remains uncertain when AI systems are embedded within human teams and organi...

Comparative analysis of proton collision effects in silicon on insulator MOSFETs using steady-state and transient responses

Proton irradiation degrades MOSFETs through multiple, spatially distinct mechanisms, yet separating the dominant damage sites remains challenging. This work presents a region-resolved electrical study of proton-irradiated partially depleted silicon-on-insulator (PDSOI) nMOSFETs,...

A Novel Relationship Between Gamma Ray Burst Duration and Photospheric Radius

Abstract Long gamma-ray bursts (lGRBs) are associated with jets in Type Ic broad-line supernovae. The collapsar model provides a theoretical framework for the jet formation from the core collapse of a massive star in such supernovae. The gamma-ray burst (GRB) can only be produced...