Peking University

Regional alterations in bone microstructure, muscle, and fat of the knee following anterior cruciate ligament rupture: a laboratory study in rabbit model

To investigate the temporal alterations in bone, muscle, and fat tissues in an anterior cruciate ligament transection (ACLT) rabbit model. A total of 24 male New Zealand White rabbits underwent ACLT in the right knee. The animals were euthanized at 3, 6, 9, and 12 weeks post-ACLT...

Organoid‐Driven Open‐Flow Artificial Vessels Inspired by Insect Dorsal Vessel Circulation

ABSTRACT Embedding functional fluid transport into living biohybrid devices remains a critical bottleneck for next‐generation engineered living systems. Conventional strategies rely on external pumps or sealed microfluidic structures, restricting biological compatibility and tiss...

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...

NIR‐Responsive CaMoO 4 /Mo 3 N 2 Heterojunction Modified Biomimetic Periosteum: Synergistic Anti‐Infection and Promotion of Bone Defect Repair

ABSTRACT Treating infected bone defects remains a formidable clinical challenge due to robust bacterial antioxidant resistance and severe microenvironmental deterioration. Herein, an antibacterial biomimetic periosteum (ABP) is rationally engineered by in situ anchoring ultrasmal...

Electrochemically In Situ Formed Inverse‐Honeycomb Local Ordering for Low‐Voltage‐Hysteresis Oxygen Redox in Na/Li Layered Oxide Cathodes

ABSTRACT In oxygen‐redox cathodes, voltage hysteresis largely arises as oxygen redox generally proceeds with electrochemical reactions followed by chemical reactions that normally drive asymmetrical charge and discharge pathways. Although different superstructures, such as ribbon...

Hydroclimatic-driven pulse enrichment amplifies riverine microplastic export in developing countries

Rivers are key conduits in the global microplastic cycle, but how much they export to ` ocean and what controls this export remain unresolved. Here, we present a global daily dataset of riverine microplastic concentrations and exports and find that rivers delivered far more micro...

Associations Between Residential Indoor Environmental Indicators and Respiratory Allergic Symptoms Among Children in Shenzhen, China

Children are vulnerable to indoor environmental exposures, yet evidence from direct measurements in residential environments remains limited. This study included 115 observations from 74 children in Shenzhen during 2023–2024, with 111 observations available for regression-based a...

Transcription factor ELF-1 drives inflammatory macrophage to exacerbate AKI by GBP4/NLRs/NF-κB axis

Acute kidney injury (AKI) is an unavoidable complication and critical determinant of prognosis in renal transplantation. M1-polarized macrophages are known to exacerbate AKI progression. Preliminary clinical data reveals a positive correlation between elevated E74-like ETS transc...

Surface Hydrogenation Strategy for Constructing a 2D B12X2H8 (X = N, P, As) Family with Embedded Aromatic Icosahedral B12 Superatoms

Surface hydrogenation is a key strategy for material modification. The icosahedral B12 superatom, featuring a closed-shell electronic structure and aromatic stability, serves as an ideal building block for 2D functional materials. Using first-principles calculations, we design hi...

Bag-1 modulates lung ischemia-reperfusion injury by regulating BCL-2 family proteins and IP3R-mediated calcium release

Lung ischemia-reperfusion injury (LIRI) involves dysregulated apoptosis and calcium overload. This study explored the role of molecular chaperone BCL-2-associated athanogene 1 (Bag-1) -1 in LIRI pathogenesis. Using an A549 cell model of glucose deprivation/hypoxia-reoxygenation,...

Halo assembly bias in the early Universe: a clustering probe of the origin of the Little Red Dots

Abstract The clustering of galaxies encodes key information about the structure and assembly history of their host dark matter (DM) haloes, providing a powerful probe of the origin of extreme high-redshift systems. While halo assembly bias has been extensively studied at low reds...

Recent advances in delivery strategies for CRISPR-based genome editing

Abstract The rapid development of CRISPR genome editing technologies has established a transformative paradigm within biomedical research, drug discovery, and gene therapy. Despite the robust nuclease activity and programmable targeting exhibited by these systems, the clinical tr...

Ancient proteins identify various Denisovan remains from Southwest China

More than a decade of multidisciplinary research has identified a collection of cranial, facial and dental remains of Denisovans from across Asia, providing insight into their cranial capacity, appearance, diet and evolutionary history. However, our understanding of their spatiot...

Efficient Waveform Capture without Absorption with Synthesis of Complex Frequencies

Abstract An optical waveform can be synthesized using complex-frequency waves as well as real-frequency harmonic waves. While a single complex-frequency wave with exponentially rising waveform can be perfectly absorbed in lossless structures. Here, we propose that diverse optical...

Learning stochastic dynamics and cell-fate landscapes from single-cell snapshots via optimal transport

The temporal dynamics and stochasticity of gene expression are critical to cell fate decisions, yet integrating snapshot omics data across multiple time points remains a major challenge. Here, we introduce DiffusionOT, a dynamic machine learning framework that infers cellular tra...

Association Between Lithium Use and Suicide‐Related Behaviors in Bipolar Disorder: A Multicenter Study

BACKGROUND: Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real-world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized. METHODS: In...

A multimodal deep learning method based on multiple medical images for Fuchs endothelial corneal dystrophy diagnosis

To establish a multimodal deep learning network for the automated diagnosis of Fuchs endothelial corneal dystrophy (FECD). The ResNet-50 neural network was trained and validated using patients with FECD, patients with other corneal endothelial disorders, and healthy controls. At...

Percolation transition of K -destinations reveals universal backbone of urban mobility networks

Abstract Cities are held together by a small subset of recurrent origin–destination ties, but extracting this backbone from noisy mobility data remains difficult, and most models still prioritize distance over connectivity. We build directed mobility networks from 48 months of mo...

Mitochondrial Dyes with Balanced Permeability-Fixability for Live, Fixed, and Expanded Multicellular Imaging

Abstract Mitochondrial inner-membrane ultrastructure plays a central role in cellular metabolism, aging, and cell death. However, super-resolution imaging of mitochondria after fixation remains challenging: commercially available fixable probes often lack sufficient reactivity fo...

Increasing risk of vapor pressure deficit exceeding critical thresholds for tree growth

With global warming, rising atmospheric vapor pressure deficit (VPD) has emerged as a critical driver of vegetation productivity and the terrestrial carbon sink. Yet, the thresholds beyond which VPD constrains tree growth remain poorly quantified. Using 2,953 tree-ring sites and...