Peking University

A new receptivity mechanism for the second-mode instability in hypersonic boundary layers

Direct numerical simulations of the flow over a compound delta-wing model reveal a novel receptivity mechanism for the second-mode instability in hypersonic boundary layers. This mechanism involves disturbances that propagate obliquely upward from the wall, interact with the shoc...

Association between serum p-cresyl sulfate levels and cardiac valve calcification as well as prognosis in maintenance hemodialysis patients

Abstract Objective Cardiac valve calcification is a common complication in patients undergoing maintenance hemodialysis, and is closely linked to adverse clinical outcomes. P -cresyl sulfate, a typical protein-bound uremic toxin, has been implicated in the pathogenesis of vascula...

An oral coral-like resveratrol nanocomplex protects against dry eye disease through ocular and systemic redox homeostasis

Dry eye disease (DED) is a progressive ocular disorder in which chronic inflammation and oxidative stress synergistically damage ocular tissues and impair vision. While topical anti-inflammatory and artificial tears therapies are the standard treatment for DED, their long-term ap...

A Radical Spin Ladder

Abstract The spin ladder model is an important platform bridging one-dimensional and two-dimensional magnetic systems, with its physical properties modulated by geometric configuration. As such, the S = 1/2 two-leg antiferromagnetic spin ladder has attracted attention due to its...

Discovery of CDK8/19 inhibitors as lead compounds for IL-6–dependent lymphoma enabled by the formal synthesis of cortistatin A

A formal synthesis of cortistatin A, a marine-derived steroidal alkaloid with potent anti-angiogenic and antileukemic activities, was achieved via a unique synthetic strategy that leveraged a late-stage SmI 2 -mediated oxa-bridge translocation. The de novo–synthesized simplified...

UAV-Satellite Integration Reveals Continuous Methane Emission Variability from Chinese Coal Mine Ventilation Shafts

Abstract Satellite quantification of coal mine methane lacks validation for continuously operating ventilation systems with high temporal variability. We integrate 75 unmanned aerial vehicle (UAV) flights (30 successful, 13 days) with 6.5 years of satellite observations at a Chin...

Barriers and Enablers Influencing Adherence to ERAS Protocols in Gastrointestinal Surgery: A Scoping Review

Background/Objective: Enhanced recovery after surgery (ERAS) is a global surgical quality improvement initiative that aims to improve perioperative care based on evidence-based interventions. Although ERAS protocols in gastrointestinal (GI) surgery result in improved patient outc...

The illusion of clinical reasoning: a benchmark reveals the pervasive gap in vision-language models for clinical competency

The rapid integration of foundation models into clinical practice and their use for public health inquiries necessitates a rigorous evaluation of their true clinical reasoning capabilities, which extends beyond success on narrow examinations. Current benchmarks, often based on me...

Extracellular vesicle proteins monitor and interfere with CLDN18.2-targeted CAR-T cell and antibody therapies against gastrointestinal cancers

Abstract Claudin 18.2 (CLDN18.2)-targeted CAR-T cell and antibody therapies show promise against gastrointestinal cancers, but biomarkers predictive of long-term benefit and therapeutic sensitization strategies are needed. Here we show that proteins carried by circulating extrace...

Macrophage FOXO1 Inhibition Protects Against Hyperglycaemia‐Associated Kidney Injury

ABSTRACT Diabetic kidney disease (DKD) is one of the most significant microvascular complications of diabetes, characterized by high incidence and mortality; however, its pathogenesis remains unclear. Renal inflammation and macrophage infiltration play pivotal roles in driving DK...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

A five-phase evaluation framework for diagnostic and predictive medical artificial intelligence

Artificial intelligence (AI) has advanced rapidly across diagnostic, prognostic, and clinical decision-support applications, yet the pathway from laboratory performance to demonstrable clinical benefit remains fragmented and inconsistently defined. Existing evaluations rely heavi...

Does intergenerational income upward mobility increase the subjective well-being of middle-aged and older people in China?—Evidence from the China Family Panel Studies (CFPS)

Intergenerational income mobility is widely regarded as a key indicator of social vitality and opportunity, yet its consequences may extend beyond the mobile individuals themselves. Using 3956 parent–child pairs from the China Family Panel Studies, this study examines whether adu...

Nintedanib in the prevention of radiation-induced lung injury in patients with unresectable stage II-III NSCLC: A protocol for a randomized, multicenter, control group study

Background Radiation-induced lung injury (RILI) is a common and dose-limiting complication in patients with non-small cell lung cancer (NSCLC) receiving radiotherapy, especially in combination with chemotherapy and/or immunotherapy. RILI encompasses acute radiation pneumonitis (R...

Burden of Lip, Oral Cavity, and Pharyngeal Cancers in China: Estimated in 2022 and Projections to 2050

Introduction and Aims Lip, oral cavity, and pharyngeal (LOCP) cancers comprise a heterogeneous group of malignancies with a substantial and evolving disease burden in China. This study aimed to systematically evaluate the burden of LOCP cancers in China and to project future tren...

The gate to speech: Smṛtijñānakīrti’s Smra ba’i sgo mtshon cha lta bu /* Vacanamukhāyudhopama and his use of the Abhidharma philosophy of language

Abstract In the early eleventh century, the peripatetic Indian scholar Smṛtijñānakīrti – Dran pa ye shes grags pa in Tibetan – overcame great hardship and many obstacles before ultimately arriving in the central Tibetan region after which he moved on to the Khams area of western...

State-Averaged Density Matrix Embedding Theory for Local Excitations

Abstract Density matrix embedding theory (DMET) provides an elegant framework in quantum chemistry to describe local properties of chemical systems, which allows a high-level method to solve an embedded subsystem constructed based on a low-level treatment of the whole system and...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Digitally enabled GP-specialist collaborative care helped improve hypertension outcomes and reduced hospital referrals in China

As China deepens health system reform to strengthen primary care by integrating hospital-based specialist services into community settings, empirical evidence is still limited. This quasi-experimental difference-in-differences analysis examined the effect of the digitally enabled...

Fluorescent protein ticker tape (FPTT): Multiplexed recording of transcriptional dynamics in living cells and in vivo

Recording and real-time imaging of promoter activities are critical for deciphering signaling cross-talk, but technologies for simultaneously capturing multiple transient events in living cells are lacking. Here, we design fluorescent protein–based ticker tapes (FPTT) for multipl...