Institution
Peking University
Recent research
- Health & Medicine
The continuous antigenic evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly undermined the effectiveness of monoclonal antibody (mAb) therapies, underscoring the need for innovative approaches that improve therapeutic mAb breadth and durabili...
- Climate & EnvironmentOpen access
Reconstructing flood-induced human mobility using LLM agent with disaster context adaptation
Understanding human mobility during extreme flood events is critical for emergency evacuation and resilient transport planning, yet flood-induced behavioral heterogeneity remains difficult to characterize. Progress has been constrained by data scarcity and the inherent complexity...
- Physics & SpaceOpen access
Convective Amplification of Ionospheric Feedback by a Finite‐Duration Inertial Alfvén‐Wave Source
Abstract We investigate the ionospheric feedback instability (IFI) driven by a finite‐duration localized source of inertial Alfvén waves. Wave‐excited conductance perturbations undergo Pedersen mobility drift in the convection and wave electric fields and are amplified. A causal...
- Engineering & Technology
ABSTRACT Engineered tissues and organoids offer transformative potential for drug screening and regenerative medicine, yet their application is constrained by limited size and slow maturation. Despite the development of various channel networks for large‐scale engineered tissue p...
- Engineering & TechnologyOpen access
Recurrent patellar dislocation (RPD) is commonly associated with patellar maltracking, and the Jumping J sign may indicate a severe instability phenotype. The optimal surgical strategy for patients with this sign remains unclear. The purpose of this study was to compare clinical...
- Engineering & Technology
Conformational ordering in two-dimensional (PEA)2PbBr4 single crystals driven by thermal annealing
Along with their improved stability and tunable quantum well structures, two-dimensional (2D) perovskites have become potential candidates for developing high-efficiency optoelectronic devices, while the atomic configuration of the materials governs their optoelectronic propertie...
- Health & Medicine
Background: Accurate medical record front-page (discharge summary face sheet) documentation supports diagnosis-related group (DRG) classification and payment review. Evidence on disease-specific management for diabetic nephropathy (DN) remains limited. Objective: To evaluate asso...
- Physics & SpaceOpen access
Antiferromagnetism and tightly bound Cooper pairs induced by kinetic frustration
Antiferromagnetism and superconductivity are often viewed as competing orders in correlated electron systems. Here, we demonstrate that kinetic frustration in hole motion facilitates their coexistence within the square-lattice repulsive Hubbard model. Combining exact analytical s...
- Materials & Energy
Three-Dimensional Covalent Organic Framework for the Capture of Nitrogen Dioxide
Abstract We report the first adsorption isotherm of nitrogen dioxide (NO2) in covalent organic frameworks (COFs). Leveraging the dihedral angle (43.6°) of the biphenyl unit in biphenyl-3,3′,5,5′-tetracarbaldehyde, upon reaction with p-phenylenediamine, a three-dimensional COF, PK...
- Health & Medicine
ABSTRACT Background Oral frailty is a comprehensive indicator of age‐related oral decline, yet its heterogeneity and association to depression are poorly understood. We aimed to identify latent classes of oral frailty and evaluate the association between dietary diversity and dep...
- Health & MedicineOpen access
Background/Objectives: Fluoroscopy permits direct assessment of catheter course and tip position during totally implantable venous access device (TIVAD) placement. We compared left- and right-sided internal jugular vein (IJV) port placement in breast cancer. Methods: This retrosp...
- Health & Medicine
PURPOSE: To determine maximal outcome improvement (MOI) thresholds for patient-reported outcome measures and identify predictors of achieving them after autologous osteoperiosteal transplantation (AOPT) for cystic osteochondral lesions of the talus. METHODS: Patients with Hepple...
- Materials & Energy
ABSTRACT Plasmon‐mediated catalysis provides a promising route for enhancing photocatalytic hydrogen generation from ammonia borane (NH 3 BH 3 ), yet the reaction rate remains limited by insufficient charge generation and separation. Herein, we address this limitation by developi...
- Society & Economics
ABSTRACT Cities have become the level at which the right to food is either operationalized or left abstract, yet we have little comparative vocabulary for describing how they do it. This article examines local food observatories and monitoring mechanisms in four cities, namely, S...
- Health & MedicineOpen access
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with gemcitabine resistance remaining a major clinical challenge. Although cancer stemness and autophagy have both been implicated in PDAC chemoresistance, the mechanism by which their crosst...
- AI & ComputingOpen access
A Deterministic Algorithm for Minimum Witness Convolution Below the Three-Halves Exponent
Given two length-n Boolean arrays, minimum witness convolution asks, for each output position k, for the least index i with A[i]B[k − i] = 1. We give a deterministic algorithm taking Õ(n1.49644) time, and therefore O(n1.49645) time, on a word RAM with O(log n)-bit words. The cons...
- AI & ComputingOpen access
Sharp Half-Density Language Generation with Self-Replay Using Membership Queries
We study language generation from a complete enumeration of an unknown member of a countable family of infinite languages, when the input stream may also replay any earlier output, including erroneous outputs. We prove that a single deterministic oracle algorithm, using only memb...
- Biology
Abstract Machine-learning-guided directed evolution can reduce the experimental burden of protein engineering by prioritizing variants before they are tested. In practice, however, many campaigns begin with few or no target-specific measurements, face choices about how to use het...
- Health & Medicine
Golgi disassembly: a key process for autophagy-mediated regulation of oocyte spindle migration
Although the Golgi apparatus undergoes extensive disassembly during mitosis to ensure its equitable partitioning into two daughter cells, the extreme asymmetry of oocyte meiosis obviates this need, raising fundamental questions about the existence and necessity of Golgi disassemb...
- Health & MedicineOpen access
Cornus mas L. Ameliorates Hepatic Insulin Resistance in High-fat Diet-induced Diabetic Mice
Background Type 2 diabetes (T2D) remains a prominent chronic metabolic disease characterized by hyperglycemia worldwide. Insulin resistance is the primary risk factor contributing to T2D development. Cornus mas L. is a natural product shown to play a regulatory role in metabolic...