Peking University

The Longitudinal Changes of Cervical Sagittal Alignment in a Non-surgical Cohort: A 12-Year Longitudinal Study

Study Design A retrospective longitudinal observational cohort study. Objective This study aimed to quantitatively evaluate the natural progression of cervical sagittal alignment parameters in non-surgical patients over a mean 12-year follow-up period, with a specific focus on ag...

Fine-tuning an ECG foundation model to predict coronary CT angiography outcomes

<title>Abstract</title> Coronary artery disease (CAD) remains a major global health burden. Accurate identification of the culprit vessel and assessment of stenosis severity are essential for guiding individualized therapy. Although coronary CT angiography (CCTA) is the first-lin...

Longitudinal gut microbiome dynamics in neurosurgical ICU patients: Enterococcus expansion as a feature of microbial restructuring

Abstract Background Gut microbiota alterations are commonly observed in critical illness, but their temporal dynamics in neurosurgical ICU patients remain insufficiently characterized. This study aimed to describe postoperative microbial trajectories and their clinical context du...

Liver sinusoidal endothelial cells in liver diseases and hepatocellular carcinoma: molecular mechanisms, physiology, and therapies

Abstract Liver sinusoidal endothelial cells (LSECs) form a specialized discontinuous microvascular interface between sinusoidal blood and the hepatic parenchyma. Functioning as a central regulator of hepatic homeostasis, LSECs integrate metabolic, inflammatory, and hemodynamic si...

Dynamics of artificial aquaculture ponds in China from 2015 to 2025

Artificial aquaculture ponds (AAPs) play a critical role in ensuring food security, supporting rural economic development, and shaping ecological landscapes. Yet, a nationally consistent, high-resolution, and individual-scale dataset of these ponds has been unavailable, hindering...

BeyondFreeze Concentration:Interfacial ProcessesShape Cr(VI) Reduction by Organic Acids in Frozen Systems

Abstract Ice-phase Cr(VI) reduction is commonly attributed to freeze concentration and proton enrichment, implicitly assuming solution-like reaction mechanisms. However, this study reveals that interfacial processes serve as a critical complement to freeze concentration and stron...

In vivo labeling–based proteomic analysis of early follicle oocytes and cisplatin-induced alterations in mice

Abstract A systematic proteomic profile of oocytes from early-stage follicles, particularly primordial follicles, is critical to protect female reproductive capacity in the context of chemotherapy, yet progress has been hindered by the rarity of oocyte samples and technical chall...

Optimizing coronary CT angiography in patients with delayed contrast arrival using a free-breathing, high-threshold bolus-tracking protocol

OBJECTIVE: To investigate the performance of a free-breathing coronary computed tomography angiography (CCTA) protocol using a high-threshold bolus-tracking strategy in improving coronary enhancement and diagnostic visualization in patients with delayed contrast arrival. MATERIAL...

Mandated to Change, Pressured to Survive: How Newly Appointed CEOs Use Resonance to Manage Strategic Change–Early Survival Dilemma

Abstract Newly appointed CEOs often enter office with a mandate to initiate strategic change, yet such change disrupts established routines and interests, frequently provoking resistance from organizational stakeholders. This creates a fundamental leadership transition dilemma: t...

Uncertainty-inspired open-set model for identifying infantile fundus abnormalities

Accurate and safe identification of infantile fundus abnormalities is critical for large-scale screening, yet remains challenging because of heterogeneous disease presentations and overconfident predictions by conventional artificial intelligence (AI) models. In this study, we ai...

Encapsulated CsPbBr3 quantum dots with asymmetric chiral magneto-optoelectronic responses

Quantum emitters having non-trivial spin polarizations are highly demanded for chiral quantum devices and quantum photonic technologies. Here we investigate the magneto photoluminescence spectroscopy of perovskite quantum dots encapsulated in silica and report an observation of c...

Compressive Sensing for Reconstruction of Noise from an Aeroengine with Elliptic-Shaped Intake

Abstract Based on our prior theoretical model for elliptical mode detection, compressive sensing is introduced in this work to overcome the limitations of Nyquist-Shannon sampling. The key contribution is showing how to apply compressive sensing to an elliptic duct, which holds p...

Dental Erosion and Therapeutic Options

Tooth wear is a common, multifactorial non-carious dental hard tissue disease, and it may lead to a range of problems such as hypersensitivity, occlusal dysfunction, and aesthetic defects, significantly impacting patients’ oral health and quality of life. This article aims to sys...

Oral nonpeptide GLP-1 receptor agonist VCT220 for obesity treatment: a randomized, double-blind, phase II trial

VCT220 is a novel nonpeptide, orally available glucagon-like peptide-1 receptor agonist (GLP-1RA) designed to reduce the complex administration of injectable GLP-1RAs and the limited bioavailability of on-marketing oral agents for obesity care. We conducted a multicenter, randomi...

Transthoracic echocardiography as a predictor of spinal anesthesia-induced hypotension in cesarean section: a prospective observational study

Spinal anesthesia-induced hypotension (SAIH) is a common complication during cesarean delivery and is closely associated with maternal intravascular volume status. However, reliable real-time assessment of volume changes remains challenging. This study aimed to evaluate whether t...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Longitudinal metagenomic profiling of gut microbiome dynamics in B-cell lymphoma patients receiving CAR-T cell therapy

Chimeric antigen receptor T-cell (CAR-T) therapy has improved outcomes in B-cell malignancies, but treatment response and immune-related toxicities remain heterogeneous. We characterized peri-infusion gut microbiome dynamics and examined their associations with subsequent respons...

The association between personal hygiene and mental health, and the modifying roles of the universal health coverage index in children and adolescents: a comparative analysis from multiple countries

Background: Personal hygiene and mental health are both core determinants of adolescent well-being, yet their interplay and the modifying role of national health system coverage remain largely unexplored in cross-national populations. Therefore, we aimed to investigate associatio...

Observation-based analysis of horizontally oriented ice crystals using dual-angle polarization lidar and cloud Doppler radar in Beijing

Abstract. Ice crystal orientation strongly influences cloud radiative properties and remote sensing retrievals, but long-term, high-resolution quantitative observations remain scarce. This study presents comprehensive case studies and statistical analyses of horizontally oriented...

Influencing Factors of Air Bubble-Induced Pressure Difference in Drainage Tubes: An In Vitro Study

AIM: This study evaluated the effect of the presence of air bubbles in a drainage tube on its pressure difference and analyzed the relationship between air bubble volume, tube diameter, drainage fluid viscosity, and pressure difference. Accordingly, it provides a theoretical basi...