Peking University

Smoking, Exhaled Carbon Monoxide, and Risk of Parkinson Disease

Importance Smoking has been associated with lower risks of Parkinson disease (PD) in epidemiological studies, but the underlying mechanisms remain poorly elucidated. Objective To investigate the association of exhaled carbon monoxide (CO) with risk of PD. Design, Setting, and Par...

Dust Substructures and Line Perturbations driven by a Forming Planet in J16120

Abstract Hints of planet formation have been independently reported within the gap of the disc around 2MASS J16120668-301027 from millimetre continuum, infrared, and Hα observations. In this work, we present new evidence for ongoing planet formation based on Atacama Large Millime...

Different oat bran dietary levels modulate diabetic dyslipidemia: gut microbiota-metabolome associations in HFD/STZ-induced rats

This study investigates responses associated with two oat bran dietary levels (15% and 30%, w /w) in diabetic dyslipidemia. High-fat diet/streptozotocin-induced diabetic rats received 15% oat bran (OBL) or 30% oat bran (OBH) dietary formulations for six weeks, followed by physiol...

Morphological variations and differences of the mandible and midfacial skeleton across different sagittal skeletal patterns and sexes: a three-dimensional geometric morphometric analysis

Maxillofacial morphological analysis is essential for orthodontic diagnosis, treatment planning, and outcome evaluation. However, previous two-dimensional or landmark-based studies can hardly comprehensively analyze three-dimensional morphology. Therefore, this study aimed to ana...

Real-time reinforcement learning for turbulent state-dependent control in a bluff-body wake

Abstract Controlling turbulent dynamics remains a major challenge because their chaotic, multiscale nature strongly affects many fluid systems. Here, we present REACT, an autonomous reinforcement learning framework for real-time, state-dependent control of turbulent wake dynamics...

Structure-Related Activity of 4-Alkylphenols in Hepatic Lipogenesis Regulated by Estrogen Receptor Agonism and Oxidative Stress

Abstract 4-Alkylphenols (APs), as typical endocrine-disrupting chemicals (EDCs) widely present in the environment and the human body, have been implicated in the disruption of lipid metabolism. However, the structure-activity relationships (SARs) and underlying mechanisms of thei...

Ultrafast 4‐Azidopyridinium‐Based Staudinger (UApS) Ligation for Bioorthogonal Labeling and Imaging

ABSTRACT Fast click reactions that operate efficiently in aqueous buffers are highly desirable across many areas of chemistry, yet remain scarce. Herein, we report an u ltrafast 4‐ a zido p yridinium‐based S taudinger (UApS) ligation that proceeds with large bimolecular reaction...

CRUX-1.0: an automatic GHG and Ozone observation system for inland Antarctica Plateau

Abstract. Antarctic inland regions, as critical hubs for global climate change monitoring, suffer from a lack of reliable long-term greenhouse gas (GHG) observation systems due to extremely low temperatures, strong winds, and limited logistical/energy support. To address this gap...

Directed evolution of Lantern enables rapid RNA and protein proximity labeling

In eukaryotic cells, the precise spatial localization of RNAs and proteins is essential for proper cellular function. Genetically encoded photocatalytic proximity labeling techniques have expanded our ability to map subcellular proteomes and transcriptomes, but their temporal res...

Drugging the “undruggable” p53: a structure-guided strategy against the Y220C mutation

Abstract Tumor Protein p53 (TP53 ) is the most frequently altered gene in human cancer, yet mutant p53 has long been considered undruggable. The Y220C mutation is exceptional because it both destabilizes the p53 DNA-binding domain (DBD) and creates a unique surface pocket absent...

Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment

Abstract Drugs for aging-related diseases may modulate aging itself, but standard clinical trial designs cannot detect such effects. Aging clocks could close this gap, but epigenetic models often yield inconsistent, hard-to-interpret results. In contrast, proteomic clocks, by tra...

Exposure to Size-Fractioned Ambient Particles Associated with Alterations in Gut Microbiome and Pro-Atherosclerotic Biomarkers in Young Adults

Abstract Background: Ambient fine and ultrafine particles are linked to the progression of atherosclerotic cardiovascular diseases, wherein gut microbiome may play a critical role. However, the underlying mechanisms and relevant metabolic pathways are not yet fully understood. Ob...

Multifunctional CuSbS2 Nanocrystals as an Integrated Flexocatalytic–Photocatalytic–Nanozymatic Platform for Antibacterial Therapy

Abstract Ultrasound-enabled catalytic strategies offer a non-invasive route for antibacterial therapy but are typically limited to non-centrosymmetric piezoelectric materials. Herein, we developed ultrasound-assisted flexocatalysis as a symmetry-independent approach for reactive...

Efficacy and Safety of DVDMS ‐Photodynamic Therapy for Dysphagia in Advanced Esophageal Cancer: A Phase II Clinical Trial

ABSTRACT Photodynamic therapy (PDT) is a localized treatment for esophageal stenosis and dysphagia in advanced cancer. This study evaluated the efficacy and safety of Cosiporfin sodium (DVDMS)‐mediated PDT for dysphagia in advanced esophageal cancer. In this Phase II trial, patie...

LRCH4 drives tumor cell proliferation by regulating the GSK3B/MEK/ERK axis in colorectal cancer

Abstract Leucine-rich repeat-containing protein 4 (LRCH4), a member of the LRCH family, has emerged as a potential prognostic biomarker in several cancers, including colorectal cancer (CRC). While other proteins in this family have been implicated in tumorigenesis, the specific r...

Depleting luminal cysteine with engineered bacteroides vulgatus alleviates experimental colitis by suppressing Th17 differentiation through an ATF6-dependent mechanism

Abstract Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease driven by dysregulated immune responses, particularly the aberrant activation of T helper 17 (Th17) cells. While microbiome-based therapies show promise, wild-type probiotics often lack specific m...

Longitudinal blood pressure trajectories before 20 weeks of gestation and adverse outcomes in women with chronic hypertension

OBJECTIVE: To explore the different patterns in early-pregnancy mean arterial pressure (MAP) trajectories before 20 weeks of gestation in pregnant women with chronic hypertension, and whether it can stratify risk for adverse perinatal outcomes. METHODS: We conducted a retrospecti...

Decoupled Synthesis Pathway via Precursor Functionalization Stabilizes High‐Voltage Nickel‐Based Cathodes

ABSTRACT Nickel‐based layered cathodes are promising candidates for high‐performance, high‐energy lithium‐ion batteries, yet their high‐voltage application is jointly limited by synthesis‐inherited structural defects and an unstable lattice oxygen framework. Here, we show that bo...

Target-Mass Borel–Cantelli Laws for IID Random LSV Maps

We prove an annealed target-mass Borel–Cantelli theorem for the two-map IID random LSV model with a common neutral fixed point. Averaging first-return operators yields a deterministic renewal convolution and a physical-time limsup law for every deterministic interval sequence wit...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...