Peking University

Discovery of a Compact Hub-Filament System in G286.21+0.17 with JWST and ALMA: Insights into Protocluster Formation and Competitive Accretion

Abstract We present a multi-wavelength study of the massive protocluster G286.21+0.17 (G286) using JWST near-infrared (NIR) imaging and ALMA H13CO+(1–0) observations. The JWST images uncover a compact (∼0.5 pc) hub-filament system (HFS), comprising a dense central hub connected b...

NCCT-based habitats and peri-tumoral radiomics enhance pre-operative prediction of benign and malignant sacral tumors

Abstract Background Differentiating between benign and malignant sacral tumors is essential for guiding treatment strategies. This study aims to develop a novel approach utilizing non-contrast computed tomography (NCCT) for the accurate classification of sacral tumors. Methods Fr...

Sleep quality is associated with gut microbiome signatures of hyperuricemia in Chinese elderly adults: a community-based case–control study

Hyperuricemia (HUA) has become a global health issue due to its rapidly increasing prevalence. Growing evidence from population and animal studies suggests that gut microbial dysbiosis and lifestyle changes are involved in serum uric acid metabolism. However, most existing studie...

SCFJFK regulates osteoblast differentiation through targeting RUNX2

RUNX2 (Runt-related transcription factor 2) is a master regulator of osteogenesis, and its genetic mutations are associated with ~65% cases of cleidocranial dysplasia (CCD), an autosomal dominant abnormal bone development disorder in humans with defective intramembranous bone for...

Revisiting nuclear quantum effects on the mechanism of electrochemical reduction of CO at Cu(111) surface

The initial hydrogenation step of *CO on Cu(111) dictates product selectivity in electrochemical CO2 reduction, yet its mechanism remains controversial. Here, at an acidic aqueous Cu(111) interface, we systematically compute the free energy profiles for *CHO and *COH formation vi...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Between Segregation and Permeability: The VOC’s Spatial Dilemma in Zeelandia Facing External Actors and Intervening Groups (1624–1662)

Abstract This study re-evaluates the “dual city” model through the case of the VOC’s Zeelandia in the seventeenth century. It argues that the settlement’s spatial order was crucially shaped not only by Dutch-indigenous relations but also by an external force: Chinese pirate-merch...

MG53 suppresses IRF7 to reprogram macrophages and promote antitumor immunity in pancreatic ductal adenocarcinoma

In pancreatic ductal adenocarcinoma (PDAC), the desmoplastic stroma and immunosuppressive tumor microenvironment (TME) present barriers to immunotherapy. Here, we show that MG53 (TRIM72) is a critical regulator of macrophage fate and anti-tumor immunity; its myeloid-specific depl...

An AI-based algorithm for retrieving aerosol optical depth and single scattering albedo using All-Sky Imager observations

Accurate measurement of aerosol optical properties is critical for understanding their radiative and environmental impacts. Currently, the most accurate retrieval of aerosol properties comes from the multi-channel surface sun photometer, but with relatively high cost and deployme...

Characteristics, treatment patterns, and outcomes of patients with transthyretin amyloidosis: a large-scale, observational, retrospective study in China (OverTTuRe China)

Abstract Background Evidence remains limited on disease journey for transthyretin (ATTR) amyloidosis in China. This study aims to analyse China data from OverTTuRe, an observational, retrospective, multi-country cohort study. Methods Data were extracted from medical records (2013...

Donor‐Site Outcomes of the Superficial Circumflex Iliac Artery Perforator Flap Versus Radial Forearm Flap in Unilateral Tongue Reconstruction: A Propensity Score Matching Analysis

ABSTRACT Background We compared the superficial circumflex iliac artery perforator (SCIP) flap with the radial forearm flap (RFF) to identify limitations restricting its widespread use. Methods We retrospectively evaluated unilateral tongue reconstruction using propensity score m...

Dynamics of a jointly commensurate moiré charge density wave

Abstract The advent of two-dimensional moiré systems has revolutionized the exploration of phenomena arising from strong correlations and nontrivial band topology. Recently, a moiré superstructure formed by two coexisting charge density waves with slightly mismatched wavevectors...

Noncanonical function of Claudin-1 mitigates lethal endoplasmic reticulum stress to drive prostate cancer lineage plasticity and chemoresistance

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC) driven by therapy-induced lineage plasticity. While endoplasmic reticulum (ER) homeostasis is critical for cell fate determination and therapeutic response, the molecular mech...

Efficacy of hemodynamic profiling-guided antihypertensive therapy in elderly patients with early morning hypertension: a randomized controlled multicenter clinical study

Abstract Objective To evaluate the efficacy of hemodynamic profiling (HDpro)-guided antihypertensive therapy in elderly patients with uncontrolled morning hypertension. Methods A multicenter randomized controlled trial was conducted in 9 hospitals in Zhejiang Province, enrolling...

Cascaded‐Gain‐Amplified Fiber Microcavity Laser With Attomolar Detection Limit

ABSTRACT Optical fiber microcavities have attracted considerable interest for their potential in developing multi‐color microlasers and high‐performance sensors. Owing to their high Q‐factor‐enhanced light‐matter interaction, fiber microcavity lasers have been extensively investi...

A Robust and Lubricating Hydrogel through a High‐Energy‐Storage and Low‐Dissipative Network Design

ABSTRACT Hydrogels are promising joint‐lubrication materials because of their similarity to cartilage. However, most tough hydrogels rely on sacrificial bonds or dissipative networks to improve mechanical strength. These mechanisms inevitably introduce additional bulk energy diss...

The provenance of cobalt in glass from the Warring States to the Qin and Han periods excavated in China and the remelting of soda-lime glass in lead-barium glass

To investigate cobalt provenance in early Chinese glass, this study statistically analyses published compositional data for cobalt-blue and comparative glass samples, focusing on finds from China dating from the Warring States to the Han period and incorporating selected comparat...

Early transmission risks of Ebola disease outbreak caused by Bundibugyo virus in the Democratic Republic of the Congo

An outbreak of Ebola disease caused by Bundibugyo virus (BDBV) has been ongoing since April 2026, primarily in the Democratic Republic of the Congo. We estimated the initial reproduction number of BDBV at 1.85 (95% CrI: 1.09, 3.25), underscoring the urgent need for timely impleme...

Convergent use of aminopeptidase N receptor by hedgehog merbecoviruses

Abstract Coronaviruses circulating in wildlife, such as European and Asian hedgehog merbecoviruses (EriCoVs), pose a potential transmission risk. Knowledge of viral receptors can inform risk assessment and development of countermeasures; however, the functional receptor for EriCo...

Novel Compound-Heterozygous Variants in PYCR1 Expand the Variant Spectrum of Autosomal Recessive Cutis Laxa

Background and Objectives: Autosomal recessive cutis laxa (ARCL) is a genetically heterogeneous group of connective-tissue disorders characterized by loose, inelastic skin and variable systemic involvement. Biallelic variants in PYCR1 are associated with PYCR1-related ARCL, inclu...