Nanjing Medical University

Breaking the Lipid Bottleneck: A Mitophagy‐Driven Nanoregulator Amplifies Ferroptosis for Colorectal Cancer Immunotherapy

ABSTRACT Colorectal cancer (CRC) therapy is severely constrained by the immunosuppressive tumor microenvironment (TME). This study presents a TME‐responsive nanometabolic regulator, ZnO 2 @Fe@HA (ZFH), designed to bridge mitochondrial dysfunction, lipid reprogramming, and ferropt...

Edentulism and persistent activities of daily living disability: evidence from CHARLS with exploratory frailty mediation analyses

Edentulism has been linked to functional decline, but its association with persistent activities of daily living (ADL) disability remains unclear. This study examined the longitudinal association between edentulism and incident persistent ADL disability among middle-aged and olde...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

A Location-Based Tailored Endovascular Strategy for Managing Posterior Inferior Cerebellar Artery Aneurysms: A Single-Center 46-Case Series

BACKGROUND AND OBJECTIVES: To evaluate the clinical and angiographic outcomes of endovascular treatment for posterior inferior cerebellar artery (PICA) aneurysms, emphasizing a location-specific treatment stratification based on PICA segmental anatomy. METHODS: Patients with PICA...

Gut microbiota functional remodeling and butyrate depletion amplify anti-Ro/La antibody-driven type I interferon activation in neonatal lupus

The early-life gut microbiome may influence susceptibility to antibody-mediated neonatal autoimmunity, but the underlying mechanisms remain poorly understood. We investigated whether gut microbial functional capacity and metabolites influence autoantibody-dependent immune activat...

Noncanonical function of Claudin-1 mitigates lethal endoplasmic reticulum stress to drive prostate cancer lineage plasticity and chemoresistance

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC) driven by therapy-induced lineage plasticity. While endoplasmic reticulum (ER) homeostasis is critical for cell fate determination and therapeutic response, the molecular mech...

Mechanosensitive epitranscriptomics in cancer: linking tumor mechanics, RNA modification, and immune escape

Solid tumors are mechanically abnormal ecosystems in which extracellular matrix stiffening, compressive stress, interstitial pressure, and aberrant fluid flow reshape cancer, stromal, and immune cell behavior. In parallel, the cancer epitranscriptome has emerged as a dynamic regu...

The lung–brain axis and neuroinflammation: a convergence model and the role of exercise

Pulmonary and neurological disorders are increasingly recognized as interconnected manifestations of systemic neuroimmune dysregulation mediated by the lung–brain axis. Diverse pulmonary insults, including acute respiratory distress syndrome, chronic obstructive pulmonary disease...

Water‐driven dispersible fiber electrode arrays for position‐dependent intracardiac electrophysiological recording

Abstract Intracardiac electrophysiological recording plays an essential role in identifying abnormal cardiac electrical activity and guiding arrhythmia diagnosis and treatment planning. A key challenge for minimally invasive intracardiac electrodes is to combine reliable transvas...

Taurine-loaded extracellular vesicles suppress mtDNA–cGAS–STING signaling by enhancing SIRT1-dependent mitophagy to alleviate neuronal senescence after spinal cord injury

Spinal cord injury (SCI) triggers a cascade of secondary pathological processes that lead to progressive neuronal dysfunction and impaired functional recovery. Although cellular senescence has been increasingly implicated in neurodegenerative conditions, its role in SCI remains p...

Morphological decoupling-based skeletal classification for clinical assessment of malocclusion

Malocclusion skeletal grading is a fundamental task in orthodontics, critical for diagnosis and treatment planning. Traditionally, cone-beam computed tomography (CBCT) is used for visual measurement, and the reconstructed lateral cephalograms are handed over to expert dentists fo...

The Glycolysis-NETosis Feedback Loop: A Metabolic-Immune Axis in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory condition of the gastrointestinal tract with rising global incidence. Neutrophils, as first-line responders to intestinal inflammation, release neutrophil ex...

Targeting Tc17 cell differentiation via the IL-6/JAK1/STAT3 signaling axis to attenuate immune checkpoint inhibitor-related colitis and promote tumor immunity

Immune checkpoint inhibitor-related colitis (IRC) is one of the most common immune-related adverse events, yet its underlying mechanisms remain unclear and treatments lack precision targeting. This study aims to elucidate the immune cell infiltration characteristics and regulator...

Intranasal delivery of BDNF-enriched small extracellular vesicles ameliorates cognitive impairment and Alzheimer’s disease-like pathology in APP/PS1 mice

Alzheimer’s disease (AD), the leading cause of dementia, still lacks broadly effective disease-modifying therapies. Here, we engineered brain-derived neurotrophic factor (BDNF)-enriched small extracellular vesicles (BDNF-sEVs) from human induced pluripotent stem cell-derived mese...

Learning curve for single-surgeon robot-assisted single-port extraperitoneal radical prostatectomy

To evaluate surgical outcomes of robot-assisted single-port extraperitoneal radical prostatectomy (E-sp-RALP) performed by a single surgeon and to characterize the procedural learning curve. Clinical data from 50 consecutive E-sp-RALP procedures performed at the Affiliated Hospit...

Biliary microbiota associated with early postoperative stone reappearance under T-Tube surveillance: an exploratory 16 S rRNA sequencing study

Early postoperative stone reappearance after biliary surgery may reflect residual stones, early re-formation, or bile duct recolonization within an altered biliary environment. Although mechanical and anatomical factors are traditionally implicated in recurrent common bile duct s...

Silicon Nitride Nanofilm Functionalized Titanium Mesh for Boosting Osseointegration by Macrophage-Related Immunomodulation

Abstract Titanium mesh-supported guided bone regeneration (TM-GBR) has emerged as a clinically effective strategy for alveolar bone augmentation in complex defects, primarily through its ability to preserve osteogenic space and correct bone volume deficiencies. However, due to th...

HMMR+ stromal cells drive human uterine development

Abstract Early uterine development in humans is a critical determinant of reproductive health and disease susceptibility during adolescence. While single-cell analyses have extensively characterized the adult uterus, the developmental origins of this organ remain poorly understoo...

Pachymic acid exhibits synergistic antitumor efficacy with lenvatinib in hepatocellular carcinoma by targeting PPARγ to inhibit glycolysis

Lenvatinib is a first-line treatment for hepatocellular carcinoma (HCC), though drug resistance may develop with long-term use. to investigate the potential of pachymic acid to enhance lenvatinib’s anti-tumor efficacy. HepG2 and LM3 cells were exposed to pachymic acid and/or lenv...

Contribution of social determinants of health to racial disparities in metabolic dysfunction-associated steatotic liver disease among US adults

Abstract Background Racial and ethnic disparities in metabolic dysfunction-associated steatotic liver disease (MASLD) persist in the US population. We studied the impact of social determinants of health (SDOH) on the likelihood of developing MASLD and explored the contribution of...