Nanjing Medical University

68Ga-NOTA-FAPI-IF7: A Heterobivalent PET Probe for Dual-Targeted Imaging of Fibroblast Activation Protein and Annexin A1 in Tumor Microenvironment

Abstract Fibroblast activation protein (FAP)-targeted PET tracers enable high-contrast tumor imaging but suffer from rapid clearance and non-specific uptake in inflammatory lesions. The heptapeptide IF7 binds annexin A1 (ANXA1) on tumor vascular endothelium, a target directly acc...

Self-buoyant cell-spheroid culture programming multi-spheroid assembly

Tempo-spatially controlled culture and assembly of cellular spheroids are fundamental in engineering tissue-like assembloids for scalable application, yet remain a technical challenge. Here, we show self-buoyant culture of cell spheroids and programmable assembly of multi-spheroi...

The total serum N-glycome landscape of hematological malignancies

A holistic and dynamic view of the glycomic landscape in hematological malignancies (HMs) remains poorly characterized, hindering clinical the application of glycomics in HMs. We launched a large-scale analysis of multicenter cohorts, combining retrospective (n=1,370) and prospec...

Sitagliptin for Acute Graft-Versus-Host Disease Prevention in Alternative Donor Transplantation: A Randomized Phase III Trial

PURPOSE This trial evaluated whether the addition of sitagliptin to antithymocyte globulin (ATG)–based prophylaxis reduces the incidence of acute graft-versus-host disease (aGVHD) after alternative donor hematopoietic stem-cell transplantation. METHODS This prospective, multicent...

Mitochondrial YME1L Restrains GRP75-Dependent ISR Activation to Prevent Podocyte Senescence in Diabetic Kidney Disease

Diabetic kidney disease (DKD) is characterized by progressive podocyte loss and cellular senescence, but the upstream stress pathways that determine podocyte fate are not fully understood. YME1L expression was markedly reduced in experimental models of DKD and was inversely assoc...

Latent profiles of male peers returning HIV self-test results after secondary distribution by men who have sex with men in Zhuhai, China

BACKGROUND: Secondary distribution of HIV self-testing (HIVST) can extend testing through social and sexual networks of men who have sex with men, but the peer subgroups reached by this approach remain insufficiently understood. We aimed to identify latent profiles of peers who r...

Using interpretable machine learning models to predict the occurrence of severe influenza in hospitalized children: a retrospective cohort study

BACKGROUND: Influenza, a prevalent disease, significantly threatens public health. Accurately predicting severe influenza occurrences is crucial for developing personalized prevention strategies and treatment plans. AIMS: This study aimed to construct a highly interpretable model...

Characteristics, Risk Factors, and Long‐Term Outcomes of Dysphagia Following Modified Uvulopalatopharyngoplasty: A Mixed‐Methods Study

ABSTRACT Objective and Design Modified Uvulopalatopharyngoplasty (mUPPP) is a standard surgical intervention for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS), but postoperative dysphagia remains an underdiagnosed and poorly managed complication due to the lack of standardise...

Maternal age‑stratified associations between Group B Streptococcus colonization and prenatal glucose metabolism and hemoglobin levels in pregnancy: a retrospective case‑control study

Objective Group B Streptococcus (GBS) colonization during pregnancy is associated with adverse outcomes. The associations between GBS colonization status and clinical parameters measured at different antenatal time points, and whether these differ by maternal age, remain unclear....

Carotid intima thickness assessed using high-resolution ultrasound as a structural correlate of endothelial dysfunction

Purpose: This study evaluated the association between carotid intima thickness (cIT), measured using high-resolution ultrasound, and endothelial cell dysfunction (ECD), assessed using flow-mediated dilation (FMD), for early atherosclerosis risk assessment.Methods: Between January...

Operating room spatial layout, capacity utilization, and resource efficiency: evidence from a tertiary hospital in China

Purpose Operating rooms (ORs) are among the most resource-intensive hospital units. This study examines how OR spatial layout influences surgical preparation time, staff movement, equipment utilization, patient flow, and OR utilization in a large tertiary hospital in China. Desig...

The CMPK2–mtDNA axis mediates doxorubicin cardiotoxicity: mechanistic links to STAT1 transcription and FAD-mediated inhibition

Abstract Aims Doxorubicin is a widely used chemotherapeutic agent whose clinical utility is limited by dose-dependent cardiotoxicity. The precise mechanisms bridging mitochondrial dysfunction to cardiac inflammatory responses remain poorly defined. Methods and results We utilized...

Large language model–assisted scoring of physician-administered parent interviews for autism screening in young children: a retrospective diagnostic case-control and agreement study

Large language models (LLMs) may assist clinicians in scoring narrative parent-report interviews, but diagnostic discrimination, score agreement, output repeatability, and clinical utility are distinct claims. We evaluated an LLM-assisted workflow for scoring a physician-administ...

Distinct functional brain network alterations associated with 5-fluorouracil- and carboplatin-based chemotherapy regimens in CRC and NSCLC patients: a combined graph theory and group ICA study based on rs-fMRI

It is not yet clear whether there are differences in the impact of different chemotherapy regimens on brain function. Especially, the distinct brain network alterations between patients underwent different regimens are still unclear. This study aimed to explore regimen-associated...

Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry

BACKGROUND AND AIMS: Patients with left atrial appendage (LAAO) devices are increasingly referred for AF ablation, yet anticoagulation strategies remain uncertain. The goal of this study was to evaluate the safety and efficacy of catheter ablation for atrial fibrillation (AF) in...

Gene-brain-behavior links revealing generative neurophysiological subtypes of suicide-related dysconnectivity in bipolar depression

Suicidal thoughts and behaviors (STBs) in bipolar depression are heterogeneous, but biologically coherent subtypes remain poorly defined. We aimed to identify neurophysiological subtypes of suicide-related dysconnectivity in bipolar depression and examine their gene-brain-behavio...

Shared genetic architecture between gastric cancer and medication-use proxy phenotypes in East Asians highlights lipid-metabolic pathways and candidate cellular contexts

Gastric cancer (GC) remains a major cause of cancer-related mortality in East Asia, and metabolic and cardiovascular comorbidities are common in the same aging populations. However, the extent to which GC shares inherited genetic architecture with medication-use proxy phenotypes...

Intraoperative free-running electromyography as a dynamic adjunct during microvascular decompression for hemifacial spasm

To characterize intraoperative free-running electromyography (EMG) patterns during microvascular decompression (MVD) for hemifacial spasm (HFS) and to evaluate their potential clinical significance, including their distribution across key surgical steps, their utility in distingu...

METTL16 supports arginine biosynthesis and suppresses IL-1β production to attenuate allergic asthma

Allergic asthma is a common disease. We aimed to investigate the role of METTL16, an N6-methyladenosine (m6A) writer, in allergic asthma and epithelial homeostasis. Here we show that pulmonary METTL16 expression was decreased in patients with allergic asthma and in a murine model...

Psoralen Suppresses Bladder Cancer Progression by Targeting AURKA: Inhibition of Proliferation and Promotion of Apoptosis

Background: Although psoralen is known for its antitumor and chemosensitizing effects across multiple malignancies, its function and molecular basis in bladder cancer (BC) remain insufficiently understood. Thus, this study examined its anti-cancer actions in BC and identified its...