Nanjing Medical University

Low tube voltage with deep learning and freezing for coronary CTA in obese patients with suspected CAD

Objective to investigate the application of low tube voltage combined with deep learning reconstruction algorithms and freeze technology in obese patients undergoing coronary computed tomography angiography (CCTA). A total of 100 patients with a BMI of 28 kg/m2 or higher who unde...

Contrastive Learning Network based on Multi-Scale Transformer (CLMT-net): EEG decoding for fine-grained motor imagery of movements within the same limb

Motor imagery (MI)-based brain-computer interfaces (BCIs) decode EEG signals into control commands. However, fine-grained MI decoding within the same limb remains challenging due to highly similar neural patterns. This paper proposes a Contrastive Learning Network based on a Mult...

Proteome-wide interaction study of fatty acids and mortality in the UK Biobank

The heterogeneity in associations between circulating fatty acids (FA) and mortality remained underexplored. Proteomics can profile the human physiological status. This study aimed to estimate interactions between FA and proteins in relation to mortality. We randomly divided 30,1...

Two‐Dimensional Speckle‐Tracking Echocardiography Combined With Stress Echocardiography in the Assessment of Coronary Artery Disease Patients Without Regional Wall Motion Abnormality

ABSTRACT Background The detection of myocardial ischemia in coronary artery disease (CAD) patients who lack regional wall motion abnormality (RWMA) at rest remains a clinical challenge. Two‐dimensional speckle‐tracking echocardiography (2D‐STE) provides a quantitative and sensiti...

Subcutaneous Belimumab Demonstrates Consistent Steady-State Pharmacokinetics and is Well Tolerated in Paediatric Patients with SLE in China: An Open-Label Study

This study assessed pharmacokinetics and safety of subcutaneous (SC) belimumab in Chinese paediatric patients with systemic lupus erythematosus (cSLE) who previously received intravenous (IV) belimumab; only the IV form is approved for cSLE in China. This single-arm, open-label,...

The efficacy, immunogenicity and safety of the LZ901 vaccine for herpes zoster virus in adults 40 years of age or older: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

In previously completed Phase 1 and 2 clinical trials, a recombinant gE-Fc fusion protein subunit vaccine adjuvanted with aluminum hydroxide (called LZ901) demonstrated favorable safety profiles and elicited robust immune responses. This randomized, placebo-controlled, double-bli...

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

ABSTRACT Ferroptosis contributes to Parkinson's disease (PD) through interconnected processes including iron dysregulation, oxidative stress, and mitochondrial dysfunction, yet current therapies targeting single pathways remain insufficient. Herein, we developed gallium–quercetin...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Acute kidney injury (AKI) is highly prevalent worldwide but lacks specific treatments. Mitochondrial dysfunction plays a central role in its pathogenesis, making mitochondrial protection a promising therapeutic strategy. Miro1 is a key regulator of mitochondrial dynamics, yet its...

Risk factors and a perioperative prediction model for postreperfusion syndrome in donation after circulatory death liver transplantation: a retrospective cohort study

Postreperfusion syndrome (PRS) is a common and clinically important complication during liver transplantation. It is characterized by marked hemodynamic instability after graft reperfusion and has been associated with adverse perioperative outcomes. However, perioperative factors...

Clinical and genetic risk factors for anthracycline‑induced cardiotoxicity in Chinese early‑stage breast cancer patients: a candidate gene study

PURPOSE: This study aimed to clarify the incidence of anthracycline-induced cardiotoxicity (ACT) and identify its clinical and candidate genetic risk factors in Chinese early-stage breast cancer patients, so as to provide evidence for clinical risk assessment and individualized c...

Preoperative triglyceride–glucose index and 30-day surgical site infection in OSCC patients without documented diabetes: a retrospective cohort study

Surgical site infection (SSI) remains an important complication after oral squamous cell carcinoma (OSCC) surgery. Although diabetes is a recognized infection risk factor, metabolic vulnerability in patients without documented diabetes is less understood. The triglyceride–glucose...

Hepatic GPR110 plays a complex and context-dependent role in metabolic dysfunction-associated steatotic liver disease

Metabolically-dysfunction-associated steatotic liver disease (MASLD)—formerly known as nonalcoholic fatty liver disease (NAFLD) —is now the most common chronic liver disease worldwide, affecting more than 30% of the global population. Recent studies have documented seemingly cont...

LGALS1 promotes gastric cancer progression and is associated with epithelial-mesenchymal transition and tumor immune microenvironment features

Galectin-1 (Gal-1, encoded by LGALS1) has been implicated in malignant progression across multiple cancer types, but its prognostic significance and association with tumor immune microenvironment features in gastric cancer (GC) remain incompletely understood. In this study, we in...

Methionine addiction in oral squamous cell carcinoma: a metabolic vulnerability targeted by engineered bacteria

Metabolic reprogramming is a defining hallmark of malignant transformation, and tumor-specific amino acid addiction has emerged as a promising therapeutic axis for precision oncology. Oral squamous cell carcinoma (OSCC) is an aggressive head and neck malignancy marked by limited...

Recent Advances in Two‐Photon Lithography of 3D Inorganic Microstructures: Glass, Ceramics, Metals, and Carbon

The fabrication of intricate three-dimensional (3D) inorganic microstructures - including glass, ceramics, metals, and carbon - is essential for next-generation devices in MEMS, photonics, energy storage, and biointerfaces. However, simultaneously achieving sub-micron resolution,...

Indicator system for regional public health emergency response capacity based on ternary space theory: construction and empirical study in China

Abstract Background Establishing a comprehensive national public health emergency management system is essential for ensuring population health. However, pronounced disparities in economic development and healthcare resources among China’s provinces have led to heterogeneous publ...

Longitudinal TyG index trajectories and renal function decline in a high cardiovascular-risk Chinese cohort: a sex-stratified analysis

This study aimed to identify longitudinal triglyceride-glucose (TyG) index trajectories and evaluate their association with annual estimated glomerular filtration rate (eGFR) change in a high cardiovascular-risk Chinese cohort, with sex-stratified analyses. A prospective cohort a...

Monoclonal immunoglobulin‐associated kidney lesions with coexistent pathological patterns: clinicopathological features and outcomes

AIMS: Monoclonal gammopathy-associated kidney lesions typically present with a single pathological pattern, but the coexistence of multiple patterns in the same patient is rare and poorly characterized. This study aimed to delineate the clinicopathological spectrum and outcomes o...