Nanjing Medical University

Integrated analysis of single-cell and transcriptome data reveals temporal dynamics of microglial phagocytic reprogramming in neuropathic pain progression

Abstract Neuropathic pain (NP) often progresses from acute to chronic, but the mechanisms driving this transition remain unclear. Microglia play a central role in spinal sensitization, yet their functional evolution during pain chronification is poorly understood. Through integra...

Lignin valorization orbiting pharmacological molecules and materials

This Perspective summarizes the research strategies, current challenges and potential directions for converting native lignin polymers into pharmaceutical molecules and materials.

Transcriptomic and histological analyses reveal immune dysregulation in BK virus-associated nephropathy

Abstract BK virus-associated nephropathy (BKVN) is an important cause of kidney allograft failure and involves complex immune responses. This study aimed to characterize gene expression changes and immune microenvironment features in BKVN tissues using transcriptomic analysis. Us...

Insight impairment mediates the effect of SOX2-OT polymorphism on antipsychotic response in first-episode schizophrenia

Insight impairment is a core clinical feature of schizophrenia that predicts poor treatment adherence and unfavorable prognosis. Genetic factors have been increasingly recognized as a likely basis for inter-individual variability in insight; however, direct evidence for a complet...

Association between subjective well-being and the risk of cardiometabolic multimorbidity in older Chinese adults: effect modification by the integrated healthy lifestyle score

This study aimed to ascertain the association between subjective well-being (SWB) scores and the cardiometabolic multimorbidity (CMM) risk, and evaluate the potential modifying effect of integrated healthy lifestyle scores among older Chinese adults. A prospective cohort study wa...

MSTO1 promotes hepatocellular carcinoma progression and represents a potential target for immunotherapy

The incidence of hepatocellular carcinoma (HCC) has increased over recent decades. While significant progress has been achieved in immunotherapy, the five-year survival rate is still unsatisfactory because of the low response rate and acquired resistance in a few patients, which...

Intrinsic capacity, genetic susceptibility and incident inflammatory bowel disease: a prospective cohort study in UK Biobank

Abstract Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder, but whether intrinsic capacity (IC), a multidomain measure of functional reserve, is associated with incident IBD remains unclear. We analysed 427,489 UK Biobank participants free of IBD at baseline...

Temporoparietal structural-functional coupling abnormalities in drug-naïve youths with major depressive disorder and suicidal ideation

Major depressive disorder (MDD) in youth is associated with higher suicide risk. Although white matter and functional connectivity abnormalities have been reported in MDD patients with suicidal ideation (SI), how brain structure and function interact abnormally remains unclear. W...

Joint longitudinal trajectories of depressive symptoms and cognitive function in relation to new-onset stroke among adults aged ≥ 50 years with diabetes or prediabetes: a multi-cohort study

Adults aged ≥ 50 years with diabetes or prediabetes frequently experience depressive symptoms and cognitive impairment, both of which may be associated with cerebrovascular vulnerability. However, little is known about whether their joint longitudinal patterns are associated with...

Rickettsia japonica strain YC21 from a fatal human case in China: comparative genomics and experimental characterization of infection phenotypes

Rickettsia japonica causes Japanese spotted fever (JSF), an emerging severe tick-borne disease in East Asia. We recently isolated strain YC21 from the first laboratory-confirmed fatal JSF case in China. This study aimed to characterize the genomic features and infection phenotype...

Comparative effects of vonoprazan-based and esomeprazole-based dual therapy on Helicobacter pylori eradication and short-term gut microbiota changes

Abstract Objective This study aimed to compare the Helicobacter pylori (H. pylori) eradication efficacy, safety, patient compliance, and short-term effects on the gut microbiota of vonoprazan-based potassium-competitive acid blocker (P-CAB) dual therapy and esomeprazole-based pro...

Association of systemic inflammatory indices NLR, SIRI, and MHR with carotid plaque in middle-aged and older adults: a retrospective cross-sectional study

To examine the associations of the neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI), and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) with carotid plaque in middle-aged and older adults. This retrospective cross-sectional study inc...

Quality and reliability of leukaemia-related short video content on Bilibili and TikTok: a cross-sectional study

Abstract Background Short‑video platforms have become a primary source of health information in China, yet the quality and reliability of disease‑related content remain largely unregulated. Numerous cross‑sectional studies have revealed suboptimal quality, significant platform di...

Comparing the diagnostic value of different obesity indices in prediabetes: a cross-sectional study in China

Diabetes, particularly type 2 diabetes, has emerged as a significant public health burden globally, and prediabetes is a high-risk state for type 2 diabetes. This study aimed to compare the diagnostic performance of body mass index (BMI), waist circumference (WC), waist-to-hip ra...

High immunosuppressants variability adversely affects post-transplant recurrence for patients with hepatocellular carcinoma

Tumor recurrence after liver transplantation (LT) for hepatocellular carcinoma (HCC) is the most significant obstacle impacting the prognosis of patients. Managing the clinical application of immunosuppressive agents is difficult, owing to their limited therapeutic range and nota...

Batatasin III alleviates inflammatory bowel disease by suppressing MMP7 and NFκB signaling in macrophages and restoring gut microbial balance

Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is characterized by chronic intestinal inflammation, disruption of the mucosal barrier, and immune dysregulation. Recent evidence underscores the role of gut macrophages, microbiota, and proinfla...

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

ABSTRACT Toosendanin (TSN) is a highly potent natural anticancer compound derived from the fruit of Fructus Meliae Toosendan. In this study, TSN inhibited melanoma cell proliferation and cell‐cycle progression, induced apoptosis, and suppressed metastasis in both in vitro and in...

Non-linear associations of plasma 25-hydroxyvitamin D with serum homocysteine and hyperhomocysteinemia in Chinese adults: a cross-sectional study

Abstract Background Plasma 25-hydroxyvitamin D [25(OH)D] deficiency and elevated homocysteine (Hcy) levels are both well-established risk factors for cardiovascular disease (CVD). However, the relationship between 25(OH)D and Hcy remains unclear. To explore the association betwee...

Severity-dependent alterations in oral microbiota and antibiotic resistance in children with dental fluorosis

Backgroud Dental fluorosis is a prevalent endemic condition, yet its impact on the oral microbiota structure and resistance in children remains understudied.Objective To assess the microbial composition, diversity, functional pathways and co-occurrence patterns among urinary fluo...

Development and internal validation of a nomogram for predicting sepsis risk in neonates with pneumonia

To develop and internally validate an individualized model for predicting sepsis risk in neonates with pneumonia and to support early risk stratification at admission. Clinical records of 817 neonates with pneumonia admitted to the Department of Neonatology, Jiangsu Province (Suq...