Nanjing Medical University

Heatmap-seeded spatially grounded query Transformers improve astrocyte soma detection across Immunostains and scan resolutions

<title>Abstract</title> Background: Automated astrocyte quantification in human immunohistochemistry (IHC) is hindered by stain variability and dense clustering. Standard Transformers often miss faint somata due to agnostic initialization, while CNNs struggle with overlapping pro...

Plant-based diet and risk of cognitive decline among older adults: a community-based prospective cohort study

Background: Diet serves as a modifiable risk factor for cognitive decline, yet evidence on plant-based diets and cognitive ageing remains limited. We examined the association between plant-based diets and cognitive decline.Methods: A total of 6,721 participants from the Chinese L...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

FOXA2 Transcriptionally Activates SIRT1 to Inhibit Cochlear Ferroptosis in Noise-Induced Hearing Loss

Background: Noise-induced hearing loss (NIHL) is a pervasive occupational health challenge, yet the individual susceptibility mechanisms remain unclear. Ferroptosis, an iron-dependent form of programmed cell death, has been implicated in cochlear hair cell damage. This study aims...

LPA deficiency in follicular fluid linked to impaired oocyte maturation through BCAA metabolism-mediated mitochondrial dysfunction

Abstract Lysophosphatidic acid (LPA) is known to be crucial for oocyte developmental competence, but the underlying molecular mechanisms remain unclear. In this study, we investigated the mechanistic relationship between follicular fluid LPA levels and oocyte quality determinants...

Effect of SEEKflex-guided versus conventional intubation on hemodynamic responses in elderly hypertensive patients: a randomized controlled trial

In elderly patients with preexisting cardiovascular and cerebrovascular diseases, laryngoscopy and tracheal intubation can provoke substantial hemodynamic disturbances, including hypertension and tachycardia, which may precipitate major cardiovascular or cerebrovascular events an...

Association between remnant cholesterol inflammatory index and new-onset stroke in different glycemic metabolic states: insights from the China health and retirement longitudinal study

The remnant cholesterol inflammatory index (RCII) has been proposed as a novel biomarker for lipid dysregulation and inflammation, and has also been suggested as a potential risk factor for diabetes. However, the association between RCII and the incidence of new-onset stroke acro...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Low tube voltage with deep learning and freezing for coronary CTA in obese patients with suspected CAD

Objective to investigate the application of low tube voltage combined with deep learning reconstruction algorithms and freeze technology in obese patients undergoing coronary computed tomography angiography (CCTA). A total of 100 patients with a BMI of 28 kg/m2 or higher who unde...

Dynamic Succession of the Early-Life Gut Microbiota and the Regulatory Role of Human Milk Oligosaccharides

Early-life nutrition and the gut microbiota interact to shape host health programming. During early-life development, spanning the neonatal period of initial gut colonization through infancy to toddlerhood, the gut microbiota undergoes dynamic succession driven by feeding pattern...

Contrastive Learning Network based on Multi-Scale Transformer (CLMT-net): EEG decoding for fine-grained motor imagery of movements within the same limb

Motor imagery (MI)-based brain-computer interfaces (BCIs) decode EEG signals into control commands. However, fine-grained MI decoding within the same limb remains challenging due to highly similar neural patterns. This paper proposes a Contrastive Learning Network based on a Mult...

Proteome-wide interaction study of fatty acids and mortality in the UK Biobank

The heterogeneity in associations between circulating fatty acids (FA) and mortality remained underexplored. Proteomics can profile the human physiological status. This study aimed to estimate interactions between FA and proteins in relation to mortality. We randomly divided 30,1...

Two‐Dimensional Speckle‐Tracking Echocardiography Combined With Stress Echocardiography in the Assessment of Coronary Artery Disease Patients Without Regional Wall Motion Abnormality

ABSTRACT Background The detection of myocardial ischemia in coronary artery disease (CAD) patients who lack regional wall motion abnormality (RWMA) at rest remains a clinical challenge. Two‐dimensional speckle‐tracking echocardiography (2D‐STE) provides a quantitative and sensiti...

Subcutaneous Belimumab Demonstrates Consistent Steady-State Pharmacokinetics and is Well Tolerated in Paediatric Patients with SLE in China: An Open-Label Study

This study assessed pharmacokinetics and safety of subcutaneous (SC) belimumab in Chinese paediatric patients with systemic lupus erythematosus (cSLE) who previously received intravenous (IV) belimumab; only the IV form is approved for cSLE in China. This single-arm, open-label,...

The efficacy, immunogenicity and safety of the LZ901 vaccine for herpes zoster virus in adults 40 years of age or older: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

In previously completed Phase 1 and 2 clinical trials, a recombinant gE-Fc fusion protein subunit vaccine adjuvanted with aluminum hydroxide (called LZ901) demonstrated favorable safety profiles and elicited robust immune responses. This randomized, placebo-controlled, double-bli...

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

ABSTRACT Ferroptosis contributes to Parkinson's disease (PD) through interconnected processes including iron dysregulation, oxidative stress, and mitochondrial dysfunction, yet current therapies targeting single pathways remain insufficient. Herein, we developed gallium–quercetin...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Acute kidney injury (AKI) is highly prevalent worldwide but lacks specific treatments. Mitochondrial dysfunction plays a central role in its pathogenesis, making mitochondrial protection a promising therapeutic strategy. Miro1 is a key regulator of mitochondrial dynamics, yet its...

Preoperative triglyceride–glucose index and 30-day surgical site infection in OSCC patients without documented diabetes: a retrospective cohort study

Surgical site infection (SSI) remains an important complication after oral squamous cell carcinoma (OSCC) surgery. Although diabetes is a recognized infection risk factor, metabolic vulnerability in patients without documented diabetes is less understood. The triglyceride–glucose...

Clinical and genetic risk factors for anthracycline‑induced cardiotoxicity in Chinese early‑stage breast cancer patients: a candidate gene study

PURPOSE: This study aimed to clarify the incidence of anthracycline-induced cardiotoxicity (ACT) and identify its clinical and candidate genetic risk factors in Chinese early-stage breast cancer patients, so as to provide evidence for clinical risk assessment and individualized c...