Nanjing Medical University

Risk factors and a perioperative prediction model for postreperfusion syndrome in donation after circulatory death liver transplantation: a retrospective cohort study

Postreperfusion syndrome (PRS) is a common and clinically important complication during liver transplantation. It is characterized by marked hemodynamic instability after graft reperfusion and has been associated with adverse perioperative outcomes. However, perioperative factors...

Methionine addiction in oral squamous cell carcinoma: a metabolic vulnerability targeted by engineered bacteria

Metabolic reprogramming is a defining hallmark of malignant transformation, and tumor-specific amino acid addiction has emerged as a promising therapeutic axis for precision oncology. Oral squamous cell carcinoma (OSCC) is an aggressive head and neck malignancy marked by limited...

Hepatic GPR110 plays a complex and context-dependent role in metabolic dysfunction-associated steatotic liver disease

Metabolically-dysfunction-associated steatotic liver disease (MASLD)—formerly known as nonalcoholic fatty liver disease (NAFLD) —is now the most common chronic liver disease worldwide, affecting more than 30% of the global population. Recent studies have documented seemingly cont...

Recent Advances in Two‐Photon Lithography of 3D Inorganic Microstructures: Glass, Ceramics, Metals, and Carbon

The fabrication of intricate three-dimensional (3D) inorganic microstructures - including glass, ceramics, metals, and carbon - is essential for next-generation devices in MEMS, photonics, energy storage, and biointerfaces. However, simultaneously achieving sub-micron resolution,...

LGALS1 promotes gastric cancer progression and is associated with epithelial-mesenchymal transition and tumor immune microenvironment features

Galectin-1 (Gal-1, encoded by LGALS1) has been implicated in malignant progression across multiple cancer types, but its prognostic significance and association with tumor immune microenvironment features in gastric cancer (GC) remain incompletely understood. In this study, we in...

Indicator system for regional public health emergency response capacity based on ternary space theory: construction and empirical study in China

Abstract Background Establishing a comprehensive national public health emergency management system is essential for ensuring population health. However, pronounced disparities in economic development and healthcare resources among China’s provinces have led to heterogeneous publ...

Longitudinal TyG index trajectories and renal function decline in a high cardiovascular-risk Chinese cohort: a sex-stratified analysis

This study aimed to identify longitudinal triglyceride-glucose (TyG) index trajectories and evaluate their association with annual estimated glomerular filtration rate (eGFR) change in a high cardiovascular-risk Chinese cohort, with sex-stratified analyses. A prospective cohort a...

Monoclonal immunoglobulin‐associated kidney lesions with coexistent pathological patterns: clinicopathological features and outcomes

AIMS: Monoclonal gammopathy-associated kidney lesions typically present with a single pathological pattern, but the coexistence of multiple patterns in the same patient is rare and poorly characterized. This study aimed to delineate the clinicopathological spectrum and outcomes o...