Nanjing Medical University

METTL16 supports arginine biosynthesis and suppresses IL-1β production to attenuate allergic asthma

Allergic asthma is a common disease. We aimed to investigate the role of METTL16, an N6-methyladenosine (m6A) writer, in allergic asthma and epithelial homeostasis. Here we show that pulmonary METTL16 expression was decreased in patients with allergic asthma and in a murine model...

Hypoxia down-regulates METTL3 and WTAP activating Integrin/FAK signaling through m6A/IGF2BP3 dependent manners in TGFBI mRNA to promote pancreatic neuroendocrine neoplasms progression

Hypoxia along with N6-methyladenosine (m6A) plays crucial roles in human tumorigenesis by influencing nearly every aspect of RNA metabolism. Nevertheless, the physiological signals that regulate the equilibrium between methylation and demethylation under hypoxic conditions have y...

miR-205-3p induces pyroptosis in triple-negative breast cancer by targeting HSP90AB1 and antagonizing MELK

Pyroptosis, a form of inflammatory programmed cell death, has emerged as a significant pathway in cancer biology, yet its regulatory mechanisms in triple-negative breast cancer (TNBC) remain incompletely understood. Integrated bioinformatics analysis of GEO datasets identified ke...

Targeting ADAR1 reprograms cold tumors to hot and enhances immunotherapy in bladder cancer

Despite significant advances in immunotherapy for certain solid tumors, bladder cancer (BCa) exhibits limited responsiveness, primarily due to its highly immunosuppressive “cold” tumor microenvironment (TME). The role of Adenosine Deaminase Acting on RNA1 (ADAR1) in regulating BC...

Smarter AI, Healthier Students? How Perceived AI Assistant Intelligence Shapes Medical Students’ Mental Health Through Learning Goal Progress and Academic Anxiety

As artificial intelligence (AI) adoption grows in medical education, AI assistants have become important learning support tools for medical students. However, existing research has primarily focused on learning performance and technology adoption, while little is known about how...

Coronary plaque phenotypes, inflammation and cardiovascular prognosis in metabolic dysfunction-associated steatotic liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) correlates with cardiovascular events. We sought to assess the association of coronary computed tomographic angiography (CCTA)-detected high-risk plaque characteristics (HRPC) and coronary inflammation with MASLD an...

The stroke crisis in ageing societies: global trends, risk factors, and clinical validation

Stroke remains a major global public health challenge, particularly among the elderly population. This study aims to integrate MIMIC-IV clinical data with GBD 2021 data to analyse epidemiological trends and regional differences in stroke among people aged 70 and above, identify k...

Microbe–Metabolite Differential Co-Occurrence Analysis Reveals Interaction-Based Microbial Signatures in Chronic Granulomatous Disease

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by impaired innate immune responses and frequent gastrointestinal involvement, yet the reorganization of gut microbiome–metabolome interactions in CGD remains poorly understood. This study aimed to ch...

CMR feature-tracking derived left atrial late diastolic strain rate is associated with long-term outcomes in non-ischemic heart failure patients with severely reduced LVEF

Abstract Background Heart failure (HF) patients with LVEF ≤ 35% remain at high risk of adverse outcomes. Cardiac magnetic resonance (CMR) feature-tracking (FT) enable the assessment of left atrial (LA) deformation, but the long-term prognostic value of LA strain parameters in thi...

Gut Microbiota-Derived Indole-3-propionic Acid Attenuates Titanium Dioxide Nanoparticle-Induced Liver Injury by Targeting Kupffer Cells via the Gut–Liver Axis

Abstract Nanotitanium dioxide (nTiO2) is widely used as a food additive, leading to chronic dietary exposure and rising health concerns. Although adverse effects on the liver and gut microbiota have been individually investigated, whether gut microbiota mediates nTiO2-induced liv...

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

ABSTRACT Renal allograft interstitial fibrosis/tubular atrophy (IF/TA) is the pathological hallmark of chronic renal allograft dysfunction (CAD) and endothelial‐to‐mesenchymal transition (EndMT) has been implicated as one of the key triggering factors. Here, we identified tumor n...

Construction and Validation of a Nomogram Model for Predicting Cancer-Specific Survival in Colorectal Cancer Based on the SEER Database

Background Colorectal cancer (CRC) remains one of the most prevalent malignancies worldwide, and accurate prognostic prediction is essential for individualized prognostic assessment and patient risk communication. The conventional TNM staging system has limited capacity for perso...

Potential therapeutic effects of Lactobacillus on Pancreatic ductal adenocarcinoma through its metabolite Harmaline

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal form of cancer. Recent research has uncovered the role of the gut microbiota in influencing PDAC progression and treatment outcomes. Dysbiosis of gut microbiota in PDAC patients has been shown to negatively...

Simultaneous Inhibition of PARP-1 and CK2α by Novel Benzothieno[3,2- d ]pyrimidin-4(1 H )-one Derivatives: A Promising Strategy to Combat Homologous Recombination Deficiency-Independent Tumors and Metastasis

Abstract Poly(ADP-ribose) polymerase 1 (PARP-1) inhibitors yield robust clinical benefits yet only work for homologous recombination deficiency (HRD) patients. To expand their utility and resolve clinical drawbacks, we synthesized dual PARP-1/casein kinase II alpha (CK2α) inhibit...

Driver gene-based prognostic model benchmarked against machine learning survival models is associated with a CAF–TGFβ–EMT-like phenotype in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is molecularly heterogeneous, limiting conventional prognostic tools. Whole-genome resequencing of six HCC cases was used only to filter candidates. Somatically mutated genes were intersected with HCC-annotated entries from five predefined driver re...

Onvansertib-mediated PLK1 inhibition impairs spermatogenesis in the murine testis

Onvansertib (ONV) is a selective inhibitor of polo-like kinase 1 (PLK1) and has promise in treating cancer. However, its potential effects on male reproductive function remain insufficiently characterized. In this study, male mice received clinically relevant doses of ONV by intr...

Neuromodulatory mechanism of repetitive transcranial magnetic stimulation for freezing of gait in Parkinson’s disease

Primary motor cortex (M1) is vital in the pathophysiology of freezing of gait (FOG) in Parkinson’s disease (PD). Repetitive transcranial magnetic stimulation (rTMS) targeting M1 may remodel locomotor circuits and alleviate FOG. This study aimed to evaluate the therapeutic efficac...

Comparison of the efficacy of different interventions for rebound pain after brachial plexus block in upper extremity surgery

BACKGROUND: Rebound pain is a common transient severe pain after peripheral nerve block subsidence, impairing block efficacy and patient satisfaction. OBJECTIVE: This study aimed to evaluate the preventive and therapeutic effects of six interventions - dexamethasone, esketamine,...

Between-assessor and temporal heterogeneity in routinely recorded postoperative symptom fields: a five-year retrospective observational study of 121,755 nursing assessments

Abstract Background Routine postoperative patient-controlled analgesia (PCA) follow-up records may be reused for audit or benchmarking, but recorded symptom rates reflect patient, clinical, temporal and documentation factors. We quantified between-assessor and temporal heterogene...

Sexual health and healthy aging: the five ‘I’s conceptual framework

Sexual health remains important throughout life, including in older age. This special collection shows that older adults need respectful, inclusive, and culturally appropriate sexual health services. The five ’I’s framework – importance, individuality, inclusion, involvement, and...