Nagoya University

Cohesin prevents local mixing of condensed euchromatic domains in living human cells

The human genome is folded into chromatin loops by the cohesin complex, forming functional chromatin domains that underlie transcription and DNA replication/repair. However, how cohesin organizes these domains in living cells, especially in active euchromatin, remains elusive. To...

Development of the noise theoretical formula for analyzing noise components on CT images

Abstract This study derived a theoretical formula for analyzing noise components in computed tomography (CT) images and evaluated the relationship between CT doses and each noise component on CT images. We devised a theoretical formula for estimating the noise components using CT...

Serum soluble Fas levels and incidence of biliary tract cancer in a nested case-control study

Abstract Background: Soluble Fas (sFas) plays multiple roles in tumorigenesis and cancer dissemination by avoiding apoptosis via connection to Fas ligand. We assessed associations of serum sFas levels with the incidence of extrahepatic biliary tract cancer (eBTC) in a prospective...

Clinical outcomes before and after the introduction of clazosentan in aneurysmal subarachnoid hemorrhage: a multicenter retrospective study of clipping and endovascular treatment

OBJECTIVE: Definitive treatment for aneurysmal subarachnoid hemorrhage (aSAH) includes microsurgical clipping and endovascular treatment (EVT). In randomized trials such as ISAT and BRAT, EVT showed superiority in short-term outcomes and comparable or favorable long-term results....

Guard cell Signal Transduction Mechanisms Controlling Stomatal Movements by Light, Abscisic Acid, CO2, VPD and Heat

Guard cell pairs form dynamic stomatal gas exchange pores in aerial tissues of plants. Guard cells regulate CO2 influx and water loss through stomata by integrating multiple environmental and internal signals. Guard cells serve as highly specialized sensory and signal processing...

Gaming Disorder Risk, Gaming Time, and Student Life Satisfaction Among Japanese Students: A Pilot Cross-Sectional Study Using the GADIS-A

Background: Problematic gaming has been linked to reduced well-being, but associations between student life satisfaction and gaming-related risk among students remain relatively untested. This pilot cross-sectional study applied the Japanese version of the Gaming Disorder Scale f...

Prominent Intrinsic Orbital Hall Effect in the 135 Kagome Metal Family and Orbital Responses in the Loop-Current Phase

The study of electronic orbital degrees of freedom, including the generation and control of orbital currents and orbital angular momentum, has emerged as a vibrant research field. Here, we study the orbital Hall effect (OHE), one of the key mechanisms for orbital current generati...

Optical Coherence Tomography‐Guided Directional Coronary Atherectomy Using Tip‐Detection Method

ABSTRACT Directional coronary atherectomy (DCA) requires precise spatial orientation. Although the tip detection method is established for intravascular ultrasound, its application in optical coherence tomography (OCT)‐guided DCA remains unestablished. We present a case of functi...

Metal‐Organic Framework‐Templated Deconstruction‐Reconstruction Enables One‐Dimensional to Two‐Dimensional Self‐Assembly of Transition Metal Phosphates for High‐Performance Ammonia Sensing

ABSTRACT Self‐assembled nanomaterials formed through the spontaneous organisation of nanoscale building blocks are attractive because of their high surface areas, strong interparticle connectivity, and ease of processing. However, programming the assembly of one‐dimensional (1D)...

Genomic and clinicopathologic analysis of conventional dendritic cell sarcomas coexisting with myeloid neoplasms

Abstract Langerhans cell sarcoma (LCS), malignant indeterminate dendritic cell tumor (IDCT), and interdigitating dendritic cell sarcoma (IDCS) are rare malignant neoplasms that originate from antigen-presenting conventional dendritic cells (cDCs). These tumors, collectively terme...

Phylogenetic diversity and genome-wide association mapping of salt tolerance traits in Cambodian rice germplasm

Abstract Soil salinity is a major problem that reduces the growth and yield of rice, particularly in coastal rice-growing regions such as certain provinces of Cambodia. This study evaluated salinity tolerance in 60 Cambodian rice varieties at germination and seedling stages and c...

Can Solar Cyclic Variability Mimic Extreme Solar Particle (Miyake) Events in Radiocarbon?

Abstract Rapid, strong enhancements in C in the Earth's atmosphere, known as Miyake events, rarely occurred over the past millennia, pointing to major radiation storms affecting Earth. They are produced by extreme solar particle events (ESPEs) and are separated by an order‐of‐mag...

Evaluating soil CO₂ fluxes during the transition from peat swamp forest to an oil palm plantation

Conversion of peat swamp forests to oil palm plantations has significant implications for soil CO 2 emissions, but the magnitude of this impact remains highly uncertain. To evaluate the effects of this conversion on soil CO₂ fluxes, monthly measurements of soil CO₂ flux, environm...

MIT / TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts

BACKGROUND: Transcription factors of the MIT/TFE family-mitfa, mitfb, and tfec-play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundant but la...

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study ass...

SoccerSynth-detection: a synthetic dataset for soccer player detection

Abstract Soccer player detection is a fundamental task in soccer video analysis, supporting downstream applications such as event analysis and tactical reconstruction. However, annotated soccer player data from broadcast videos are difficult to obtain and use at scale because of...

Diversity‐Oriented Two‐Step Annulative π‐Extension Enables Access to Structurally Complex Nanographenes

ABSTRACT The development of a general strategy for accessing structurally diverse nanographenes and polycyclic aromatic hydrocarbons (PAHs) remains a central challenge in synthetic chemistry. Although annulative π‐extension (APEX) enables the direct construction of fused aromatic...

Negative-Muon Depth Profiling Reveals Near-Surface Gold Enrichment in Historical Shachihoko Scales from Nagoya Castle

Surviving fish-scale plates from the golden shachihoko (Kin-shachi) ornaments of Nagoya Castle are rare historical gold–silver (Au–Ag) materials. Recent X-ray fluorescence (XRF) analysis and color measurements indicated a discrepancy between the bulk Au concentration and the visi...

Separating extracellular from intracellular fecal metabolites exposes cross-feeding architecture in the gut: exploring metabolite partitioning and ecological associations

The gut microbiota forms a complex ecosystem through metabolic interdependence (cross-feeding). However, conventional fecal metabolomics typically quantifies only total metabolite pools, making it difficult to distinguish extracellular-enriched metabolite pools from predominantly...

A compilation of global bio-optical in situ data for ocean-colour satellite applications – version four

Abstract. A global in situ dataset for validation of satellite products from the ESA Ocean Colour Climate Change Initiative (OC-CCI) is presented. This version of the compilation, with data starting in 1996, extends to 2025, which is important for the validation of recent algorit...