Nagoya University

Real-world safety and effectiveness of olaparib maintenance after first-relapse platinum-sensitive ovarian cancer in Japan: a multicenter historical cohort (JGOG3026)

OBJECTIVE: The primary objective of the study was to evaluate the safety and effectiveness of olaparib maintenance therapy in Japanese patients with platinum-sensitive first-relapsed ovarian cancer. The secondary objective was to survey the treatment given after the olaparib main...

No Significant Secondary Structural Change of α‐Synuclein Monomer by Site‐Specific DOPA or Phosphorylation Introduction in Its C‐Terminal Region

ABSTRACT α‐Synuclein (αSyn) is a major component of pathogenic Lewy bodies and Lewy neurites and is closely associated with Parkinson's disease. Among the various posttranslational modifications of αSyn, several have been implicated in the degeneration of dopaminergic neurons and...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Organization of the Digestive Tract and Localization of Protein Fibre in Electrophorus sp. (Gymnotiformes: Gymnotidae)

ABSTRACT Research into the electric eel ( Electrophorus ) has focused on its production of high‐voltage electrical discharges for predation and defence, and its divergence from other fish species in terms of molecular activities. However, the knowledge of its digestive biology re...

Associations of Happiness, Ikigai, and Enjoyment of Daily Life with Frequency of Forest Walking in a Japanese General Population: The Japan Multi-Institutional Collaborative Cohort Daiko Study

A number of studies have examined the acute effects of shinrin-yoku (forest bathing), or forest walking; however, only a limited number of epidemiological studies have examined the association between habitual forest walking and daily health. The aim of this study was to examine...

Observational signatures of negative mass wormholes through their shadows

Abstract Systems containing objects with negative mass (NMOs) are considered. Such a system consists of one object with positive mass and one NMO, where a bound state exists even though the force exerted by the NMO on the object with positive-mass is repulsive. Unlike standard bi...

Black-Box Construction of Partial Key Exposure Resilient Symmetric-Key Encryption Scheme

In a TLS session, the user is granted access solely to the encryption and decryption oracles, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>ℰ</mml:mi> <mml:mo stretchy="false">(</mml:mo> <mml:mi>K</mml:mi> <mml:mo>,</mml:mo> <mml:mi>·</mml:mi> <mml:...

Electrodeposition-initiated, self-catalyzed growth of 2D amorphous Fe-group metal–boron alloy mesoporous films

Two-dimensional mesoporous amorphous metallic films, particularly those based on earth-abundant Fe-group metals (Ni, Co, Fe), are highly promising for various applications due to their high surface area, structural isotropy, and abundant undercoordinated sites. However, synthesiz...

Sex-based survival differences in patients with untreated advanced oesophageal squamous cell carcinoma receiving chemotherapy and immune checkpoint inhibitors: a meta-analysis

Purpose Chemotherapy combined with immune checkpoint inhibitors (ICIs) is the standard first-line treatment for patients with advanced oesophageal squamous cell carcinoma (OSCC). Evidence from other tumour types suggests that biological sex may influence ICI efficacy, but this re...

Hydraulic Performance of Coral Reefs for Coastal Protection: Wave Transmission and Setup Characteristics

This study experimentally investigated the wave transmission and setup characteristics of biomimetic submerged structures as Nature-based Solutions (NbSs) for coastal protection. A non-porous monolithic pillar and a highly porous, multi-branched staghorn coral replica were tested...

Helicobacter pylori small RNA HPnc1470 represses HP0499/PldA/CGAT expression and modulates gastric epithelial morphology and inflammation

Helicobacter pylori persistently colonizes the stomach and contributes to gastric inflammation and carcinogenesis via sustained interactions with gastric epithelial cells. Although bacterial small RNAs (sRNAs) are crucial post-transcriptional regulators, their roles in regulating...

Static and streaming algorithms for random sampling over spatial range joins

Spatial range joins have many applications, including geographic information systems, location-based social networking services, neuroscience, and visualization. However, joins incur not only expensive computational costs but also too large result sets. A practical and reasonable...

Atomic-precision π-driven peptide hydrogel nanofibers with ordered water channels

Aromatic interactions organize molecules into ordered supramolecular architectures, while peptides form functional soft materials through hydrogen bonding and water-mediated assembly. In peptide-based systems, strong aromatic stacking is typically achieved by terminal capping, wh...

Tsunami-induced wave pressure and forces: a review of clear water to black tsunamis

This review synthesizes the evolution of tsunami load assessment from established clear-water formulations to the emerging problem of black tsunamis (sediment-laden tsunamis), focusing on wave pressure and force prediction for coastal structures. For clear-water conditions, a com...